INT78823

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Context Info
Confidence 0.24
First Reported 1998
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 2.22
Pain Relevance 1.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (SLURP1) extracellular region (SLURP1) cell adhesion (SLURP1)
Anatomy Link Frequency
corpus 1
plasma 1
epithelial cells 1
EPI 1
SLURP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
adenocard 142 100.00 Very High Very High Very High
antagonist 40 100.00 Very High Very High Very High
agonist 143 97.48 Very High Very High Very High
Angina 4 89.32 High High
Catecholamine 7 82.20 Quite High
cytokine 6 78.88 Quite High
Clonidine 2 75.00 Quite High
Antinociceptive 1 75.00 Quite High
Pain 5 73.12 Quite High
Neurotransmitter 2 72.48 Quite High
Disease Link Frequency Relevance Heat
Erectile Dysfunction 4 96.60 Very High Very High Very High
Vasculogenic Impotence 2 95.28 Very High Very High Very High
Sprains And Strains 59 94.80 High High
Bordatella Infection 1 90.72 High High
Angina 2 89.32 High High
Alopecia 2 85.68 High High
Natriuresis 1 84.12 Quite High
Diabetes Mellitus 8 81.08 Quite High
Hypertension 5 80.56 Quite High
Renal Disease 2 78.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Improvement in myocardial contractility after the course treatment with the drug was accompanied by reduction in blood plasma levels of ANUP and cGMP.
Negative_regulation (reduction) of ANUP in plasma
1) Confidence 0.24 Published 1998 Journal Lik. Sprava Section Abstract Doc Link 9844884 Disease Relevance 0.25 Pain Relevance 0.16
At halpha(2A)-, halpha(2B)-, and halpha(2C)-ARs, the selective alpha(2)-AR antagonist, atipamezole, abolished the actions of S18616: pK(b) values of 9.1, 9. 1, and 9.4, respectively.
Negative_regulation (abolished) of ARs associated with antagonist
2) Confidence 0.11 Published 2000 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 11082457 Disease Relevance 0.16 Pain Relevance 0.51
Endothelial dysfunction of human corpus cavernosum may be correlated with the loss of adenosine A2B ARs activity, indicating a possible employment of specific A2B AR agonists as anew therapeutic approach to manage severe vasculogenic impotence resistant to common vasodilators [59].
Negative_regulation (loss) of ARs in corpus associated with adenocard, agonist and vasculogenic impotence
3) Confidence 0.05 Published 2008 Journal Purinergic Signal Section Body Doc Link PMC2583210 Disease Relevance 1.13 Pain Relevance 0.41
A2B ARs have been generally defined as the “low-affinity ARs,” as their lower affinity for the endogenous ligand, adenosine, and for some typical agonists, such as 5?
Negative_regulation (defined) of ARs associated with adenocard and agonist
4) Confidence 0.04 Published 2008 Journal Purinergic Signal Section Body Doc Link PMC2583210 Disease Relevance 0.26 Pain Relevance 0.64
2A-ARs is prevented when 30 nM propranolol is included with EPI.
Negative_regulation (prevented) of ARs in EPI
5) Confidence 0.03 Published 2007 Journal BMC Pharmacol Section Body Doc Link PMC2234403 Disease Relevance 0 Pain Relevance 0.07
Our results demonstrate that isogenic inactivation of the arsS (jhp0151/HP0165) histidine kinase locus results in a 10-fold SabA-dependent increase in adherence to gastric epithelial cells in strain J99 (contains an in-frame sabA allele), but not in strain 26695 (out-of-frame sabA allele).
Negative_regulation (inactivation) of arsS in epithelial cells associated with sprains and strains
6) Confidence 0.01 Published 2008 Journal Microbiology Section Abstract Doc Link PMC2715451 Disease Relevance 0.43 Pain Relevance 0

General Comments

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