INT78827

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Context Info
Confidence 0.78
First Reported 1998
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 34
Total Number 36
Disease Relevance 18.48
Pain Relevance 15.81

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Bdkrb1) plasma membrane (Bdkrb1) signal transducer activity (Bdkrb1)
Anatomy Link Frequency
smooth muscle cells 3
smooth muscle 2
brain structures 2
central nervous system 2
epithelium 1
Bdkrb1 (Mus musculus)
Pain Link Frequency Relevance Heat
bradykinin 589 100.00 Very High Very High Very High
b2 receptor 358 100.00 Very High Very High Very High
antagonist 244 100.00 Very High Very High Very High
B1 receptor 203 100.00 Very High Very High Very High
agonist 178 99.96 Very High Very High Very High
Central nervous system 46 99.84 Very High Very High Very High
Nicotine 1056 99.80 Very High Very High Very High
Inflammation 565 99.52 Very High Very High Very High
Spinal cord 21 99.08 Very High Very High Very High
dexamethasone 122 98.38 Very High Very High Very High
Disease Link Frequency Relevance Heat
Targeted Disruption 138 100.00 Very High Very High Very High
Reperfusion Injury 320 99.82 Very High Very High Very High
Apoptosis 71 99.68 Very High Very High Very High
INFLAMMATION 625 99.52 Very High Very High Very High
Asthma 166 99.46 Very High Very High Very High
Nociception 7 99.32 Very High Very High Very High
Diabetes Mellitus 12 99.08 Very High Very High Very High
Death 60 98.80 Very High Very High Very High
Pressure And Volume Under Development 51 98.68 Very High Very High Very High
Hyperalgesia 1 98.28 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
While B2R is constitutively expressed in many tissues, B1R expression is thought to be absent, but induced under proinflammatory conditions.
Gene_expression (expression) of B1R
1) Confidence 0.78 Published 2003 Journal J. Comp. Neurol. Section Abstract Doc Link 12966562 Disease Relevance 0.37 Pain Relevance 0.27
However, the in vivo characterization of the pharmacodynamics of B1R antagonists is hindered by the low level of B1R expression in healthy tissue and the profound species selectivity exhibited by many compounds for the B1R.
Gene_expression (expression) of B1R associated with antagonist
2) Confidence 0.77 Published 2006 Journal Biol. Chem. Section Abstract Doc Link 16497152 Disease Relevance 0.27 Pain Relevance 0.35
The first is a transgenic rat over-expressing the human B1R under the control of the neuronal-specific enolase promoter; we previously reported the utility of this model in assessing human B1R receptor occupancy in the central nervous system of the rat.
Gene_expression (over) of B1R in central nervous system associated with targeted disruption and central nervous system
3) Confidence 0.77 Published 2006 Journal Biol. Chem. Section Abstract Doc Link 16497152 Disease Relevance 0.32 Pain Relevance 0.34
Liesmaa and collaborators identified increased expression of B1R in endothelium of failing human hearts.
Gene_expression (expression) of B1R in hearts
4) Confidence 0.67 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2516176 Disease Relevance 1.48 Pain Relevance 0.48
By contrast, B1R is normally weakly expressed, being strongly up-regulated in the presence of inflammatory stimuli [10], [11] or its natural agonist des-Arg10-Kallidin [12].
Gene_expression (expressed) of B1R associated with agonist and inflammatory stimuli
5) Confidence 0.67 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2516176 Disease Relevance 1.05 Pain Relevance 0.49
Real-time PCR was performed for GATA-3, T-bet, MCP-1, HO-1, B1R and B2R expression using SYBR Green assay (Applied Biosystem).
Gene_expression (expression) of B1R
6) Confidence 0.67 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2516176 Disease Relevance 0.06 Pain Relevance 0.15
The mRNA expression profile of the humanized Bdkrb1 (hBkdrb1) allele is similar to that of the mouse Bdkrb1 (mBkdrb1) in the wild-type animal.
Gene_expression (expression) of Bdkrb1
7) Confidence 0.67 Published 2006 Journal Biol. Chem. Section Abstract Doc Link 16497152 Disease Relevance 0.31 Pain Relevance 0.29
The mRNA expression profile of the humanized Bdkrb1 (hBkdrb1) allele is similar to that of the mouse Bdkrb1 (mBkdrb1) in the wild-type animal.
Gene_expression (expression) of Bdkrb1
8) Confidence 0.67 Published 2006 Journal Biol. Chem. Section Abstract Doc Link 16497152 Disease Relevance 0.31 Pain Relevance 0.29
The first is a transgenic rat over-expressing the human B1R under the control of the neuronal-specific enolase promoter; we previously reported the utility of this model in assessing human B1R receptor occupancy in the central nervous system of the rat.
Gene_expression (expressing) of B1R in central nervous system associated with targeted disruption and central nervous system
9) Confidence 0.60 Published 2006 Journal Biol. Chem. Section Abstract Doc Link 16497152 Disease Relevance 0.32 Pain Relevance 0.34
Antagonists of the B1 bradykinin receptor (B1R), encoded by the BDKRB1 gene, offer the promise of novel therapeutic agents for inflammatory and neuropathic pain.
Gene_expression (Antagonists) of B1R associated with inflammation, antagonist, neuropathic pain and bradykinin
10) Confidence 0.60 Published 2006 Journal Biol. Chem. Section Abstract Doc Link 16497152 Disease Relevance 0.26 Pain Relevance 0.32
Pro and anti-inflammatory molecule expression in B1R knockout or antagonism after renal IRI
Gene_expression (knockout) of B1R associated with targeted disruption, reperfusion injury and inflammation
11) Confidence 0.58 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2516176 Disease Relevance 1.52 Pain Relevance 0.38
We previously have observed that B1R deletion increased HO-1 and decreased MCP-1 expression [27].
Gene_expression (deletion) of B1R
12) Confidence 0.58 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2516176 Disease Relevance 1.44 Pain Relevance 0.43
These results showed that B1R deletion was beneficial throughout different reperfusion times; meanwhile protection under B2R absence was only seen at the beginning of this process.
Gene_expression (deletion) of B1R
13) Confidence 0.58 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2516176 Disease Relevance 0.35 Pain Relevance 0.25
Even more, the expression of MCP-1 was reduced while HO-1 was up regulated by B1R antagonism, confirming previous observations from our group that showed a similar expression profile in B1KO mice [27].
Gene_expression (antagonism) of B1R
14) Confidence 0.58 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2516176 Disease Relevance 1.01 Pain Relevance 0.54
Thus, B1R deletion may protect renal cells from death during IRI.
Gene_expression (deletion) of B1R associated with reperfusion injury and death
15) Confidence 0.58 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2516176 Disease Relevance 1.34 Pain Relevance 0.14
The expression of kinin B(1), but not B(2), receptor mRNA was markedly increased in the L4/5 dorsal root ganglia on the melanoma-bearing side.
Gene_expression (expression) of kinin B in dorsal root ganglia
16) Confidence 0.58 Published 2010 Journal Eur J Pain Section Body Doc Link 19932979 Disease Relevance 0.06 Pain Relevance 0
In B2KO, B1R expression was increased at 4 and 24 hours (Figure 1B).
Gene_expression (expression) of B1R
17) Confidence 0.52 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2516176 Disease Relevance 0.33 Pain Relevance 0.25
In the present study, IRI induced B1R expression and a cross-modulation between receptors was observed.
Gene_expression (expression) of B1R associated with reperfusion injury
18) Confidence 0.52 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2516176 Disease Relevance 0.87 Pain Relevance 0.35
Experimental evidence has shown that the bradykinin B1 receptor (BKB1-R) is involved in the development of type 1 diabetes and found to be upregulated alongside the disease.
Gene_expression (involved) of bradykinin B1 receptor associated with diabetes mellitus, b1 receptor and disease
19) Confidence 0.49 Published 2010 Journal Neuropeptides Section Abstract Doc Link 20092893 Disease Relevance 1.56 Pain Relevance 0.42
Interestingly, basal expression of B1 receptor has been described in spinal cord and some brain structures, such as cerebral cortex, hippocampus, thalamus, hypothalamus, amygdala, and choroid plexus epithelial cells [10,38,39].
Gene_expression (expression) of B1 receptor in brain structures associated with b1 receptor, thalamus, hippocampus, amygdala, cerebral cortex and spinal cord
20) Confidence 0.36 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC3022820 Disease Relevance 0.74 Pain Relevance 0.75

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