INT7883

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Context Info
Confidence 0.47
First Reported 1981
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 18
Total Number 19
Disease Relevance 5.49
Pain Relevance 7.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (ADRB2) plasma membrane (ADRB2) nucleus (ADRB2)
lysosome (ADRB2) cytoplasm (ADRB2) signal transducer activity (ADRB2)
Anatomy Link Frequency
platelets 3
myometrium 1
neuronal 1
SH-SY5Y 1
nerve 1
ADRB2 (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 37 99.98 Very High Very High Very High
Opioid 4 99.86 Very High Very High Very High
local anesthetic 27 99.82 Very High Very High Very High
Inflammation 143 99.26 Very High Very High Very High
Potency 22 99.14 Very High Very High Very High
agonist 153 98.16 Very High Very High Very High
mu opioid receptor 2 97.14 Very High Very High Very High
Neurotransmitter 2 96.68 Very High Very High Very High
nerve block 3 96.56 Very High Very High Very High
adenocard 33 95.80 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 155 99.26 Very High Very High Very High
Obesity 10 99.08 Very High Very High Very High
Thyroid Disease 4 97.88 Very High Very High Very High
Bordatella Infection 1 97.88 Very High Very High Very High
Adhesions 8 97.36 Very High Very High Very High
Squamous Cell Carcinoma 1 96.48 Very High Very High Very High
Rheumatoid Arthritis 6 94.60 High High
Migraine Disorders 46 93.36 High High
Fever 2 92.96 High High
Pain 2 92.68 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The lack of clear stereospecificity is consistent with the relatively low potency these agents demonstrate at inhibition of beta2AR binding.
beta2AR Binding (binding) of associated with potency
1) Confidence 0.47 Published 1997 Journal Anesth. Analg. Section Abstract Doc Link 9249110 Disease Relevance 0.17 Pain Relevance 0.86
Local anesthetics inhibit binding of ligands to beta2-adrenergic receptors (beta2ARs), and, as a consequence, inhibit intracellular cAMP production.
beta2-adrenergic Binding (binding) of associated with local anesthetic
2) Confidence 0.47 Published 1997 Journal Anesth. Analg. Section Abstract Doc Link 9249110 Disease Relevance 0 Pain Relevance 0.38
Binding competition studies, transcripts and protein analysis were then performed to determine whether any changes in the number of ADRB2 and ADRB3 binding sites and in the transcript and protein expression might explain the observed change in the contractile response between non-pregnant and pregnant myometrium to ADRB2 and ADRB3 agonists.
ADRB2 Binding (binding) of in myometrium associated with agonist
3) Confidence 0.37 Published 2007 Journal BMC Pregnancy Childbirth Section Body Doc Link PMC1892055 Disease Relevance 0 Pain Relevance 0.07
Herein we report the ability of lithium to stimulate the internalization of beta2-adrenergic receptors.
beta2-adrenergic Binding (internalization) of
4) Confidence 0.36 Published 2001 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 11594766 Disease Relevance 0.19 Pain Relevance 0.23
The correlation between increased inhibition of beta2AR binding and alkyl chain length resembles the correlation between local anesthetic potency at nerve block and increased alkyl chain length.
beta2AR Binding (binding) of in nerve associated with nerve block, potency and local anesthetic
5) Confidence 0.35 Published 1997 Journal Anesth. Analg. Section Abstract Doc Link 9249110 Disease Relevance 0.13 Pain Relevance 0.87
These two neuronal cell lines of human origin would prove useful in elucidating the action and regulation of human alpha 2-adrenergic receptors and their interaction with other receptor systems.
2-adrenergic Binding (interaction) of in neuronal
6) Confidence 0.32 Published 1989 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 2537639 Disease Relevance 0.54 Pain Relevance 0.23
Characterization of alpha 2-adrenergic receptors in human platelets by binding of a radioactive ligand [3H]yohimbine.

[3H]Yohimbine, a potent alpha 2-adrenergic antagonist, was used to label the alpha-adrenergic receptors in membranes isolated from human platelets.

2-adrenergic Binding (Characterization) of in platelets associated with antagonist
7) Confidence 0.32 Published 1981 Journal Biochim. Biophys. Acta Section Title Doc Link 6114754 Disease Relevance 0 Pain Relevance 0.26
These results suggest that [3H]yohimbine binding to hunan platelet membranes is specific, rapid, saturable, reversible and, therefore, can be successfully used to label alpha 2-adrenergic receptors.
2-adrenergic Binding (binding) of in platelet
8) Confidence 0.32 Published 1981 Journal Biochim. Biophys. Acta Section Abstract Doc Link 6114754 Disease Relevance 0 Pain Relevance 0.46
Characterization of alpha 2-adrenergic receptors in human platelets by binding of a radioactive ligand [3H]yohimbine.

[3H]Yohimbine, a potent alpha 2-adrenergic antagonist, was used to label the alpha-adrenergic receptors in membranes isolated from human platelets.

2-adrenergic Binding (binding) of in platelets associated with antagonist
9) Confidence 0.31 Published 1981 Journal Biochim. Biophys. Acta Section Title Doc Link 6114754 Disease Relevance 0 Pain Relevance 0.38
ADRB2 receptors are positively coupled to G?
ADRB2 Binding (coupled) of
10) Confidence 0.28 Published 2007 Journal BMC Pregnancy Childbirth Section Body Doc Link PMC1892059 Disease Relevance 0 Pain Relevance 0.05
Beta adrenergic receptors ADRB1 and ADRB2
ADRB2 Binding (receptors) of
11) Confidence 0.24 Published 2008 Journal Eur J Clin Pharmacol Section Body Doc Link PMC2235910 Disease Relevance 0.23 Pain Relevance 0.11
Alpha 2- and beta-adrenergic receptor binding and action in gluteal adipocytes from patients with hypothyroidism and hyperthyroidism.
beta-adrenergic receptor Binding (binding) of in adipocytes associated with thyroid disease and obesity
12) Confidence 0.15 Published 1987 Journal Metab. Clin. Exp. Section Title Doc Link 2823049 Disease Relevance 0.77 Pain Relevance 0.22
These channels have been previously showed stably interacting with 3 different metabotropic receptors (D2 and D4 dopaminergic receptors and the beta 2 adrenergic receptor) by co-precipitation in cell culture.
beta 2 adrenergic receptor Binding (interacting) of
13) Confidence 0.14 Published 2007 Journal BMC Med Genet Section Body Doc Link PMC2034370 Disease Relevance 0.87 Pain Relevance 0.42
Ascorbate binds to the beta 2 adrenergic receptor at physiological concentrations.
beta 2 adrenergic receptor Binding (binds) of
14) Confidence 0.10 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC3001466 Disease Relevance 0.12 Pain Relevance 0.23
Using the human beta 2 adrenergic receptor, ascorbate was found to bind to an outside loop of the receptor, near the agonist binding site.
beta 2 adrenergic receptor Binding (bind) of associated with agonist
15) Confidence 0.09 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001466 Disease Relevance 0.32 Pain Relevance 0.18
The combined results indicate that mu-opioid receptors and an alpha 2-adrenoceptor subtype are colocalized on the same cells in SH-SY5Y culture, which hence serves as a model to study opioid-alpha 2-adrenergic interactions.
2-adrenergic Binding (interactions) of in SH-SY5Y associated with mu opioid receptor and opioid
16) Confidence 0.06 Published 1992 Journal Eur. J. Pharmacol. Section Abstract Doc Link 1358661 Disease Relevance 0.13 Pain Relevance 1.02
Genes that were found to be affected by A2AR engagement, PGE2 or pharmacological elevation of the intracellular cyclic AMP concentration together provide a first picture of the overall impact these signals have on gene expression.
A2AR Binding (engagement) of
17) Confidence 0.02 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2654409 Disease Relevance 1.19 Pain Relevance 0.50
Most of the anti-inflammatory activities of this autacoid through A2AR engagement are thought to involve a rise in intracellular cyclic AMP concentration [22], [24], [25].
A2AR Binding (engagement) of associated with inflammation
18) Confidence 0.02 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2654409 Disease Relevance 0.74 Pain Relevance 0.50
In addition, SCH-202676 inhibited antagonist binding to the beta2-adrenergic receptor expressed in Escherichia coli, a system devoid of classical heterotrimeric G proteins.
beta2-adrenergic Binding (binding) of associated with antagonist
19) Confidence 0.00 Published 2001 Journal Mol. Pharmacol. Section Abstract Doc Link 11125021 Disease Relevance 0.10 Pain Relevance 0.41

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