INT7884

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Context Info
Confidence 0.62
First Reported 1980
Last Reported 2010
Negated 22
Speculated 15
Reported most in Abstract
Documents 102
Total Number 119
Disease Relevance 7.95
Pain Relevance 61.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Oxt) extracellular region (Oxt) response to stress (Oxt)
cytoplasm (Oxt)
Anatomy Link Frequency
neurohypophysis 23
neural lobe 17
blood 14
supraoptic nucleus 10
nucleus 9
Oxt (Rattus norvegicus)
Pain Link Frequency Relevance Heat
narcan 310 100.00 Very High Very High Very High
antagonist 256 100.00 Very High Very High Very High
agonist 130 100.00 Very High Very High Very High
Opioid 126 100.00 Very High Very High Very High
Endogenous opioid 116 100.00 Very High Very High Very High
Morphine 110 100.00 Very High Very High Very High
Enkephalin 82 100.00 Very High Very High Very High
Dynorphin 57 100.00 Very High Very High Very High
opiate 46 100.00 Very High Very High Very High
opioid receptor 37 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 73 100.00 Very High Very High Very High
Nociception 18 100.00 Very High Very High Very High
Morphine Dependence 5 100.00 Very High Very High Very High
Volume Depletion And Dehydration 20 99.06 Very High Very High Very High
Hypertension 11 98.20 Very High Very High Very High
Urological Neuroanatomy 18 98.04 Very High Very High Very High
Hyperalgesia 3 98.02 Very High Very High Very High
Pain 27 96.20 Very High Very High Very High
Hemorrhage 7 93.88 High High
Weight Gain 1 85.64 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Serotonergic control of oxytocin release during suckling in the rat: opposite effects in conscious and anesthetized rats.
Regulation (control) of Localization (release) of oxytocin associated with anesthesia
1) Confidence 0.62 Published 1983 Journal Neuroendocrinology Section Title Doc Link 6223233 Disease Relevance 0.09 Pain Relevance 0.23
These data indicate that oxytocin can be released by stimulation of peripheral nerves originating in the skin and/or muscle and in the gastrointestinal tract and thus these organs may be involved in the control of oxytocin secretion.
Regulation (control) of Localization (secretion) of oxytocin in muscle
2) Confidence 0.62 Published 1988 Journal Acta Physiol. Scand. Section Abstract Doc Link 3223304 Disease Relevance 0.16 Pain Relevance 0
Endogenous opioid pathways regulating oxytocin release therefore appear to be active during late pregnancy and during parturition itself.
Regulation (regulating) of Localization (release) of oxytocin associated with endogenous opioid
3) Confidence 0.62 Published 1988 Journal J. Reprod. Fertil. Section Abstract Doc Link 3184053 Disease Relevance 0 Pain Relevance 0.58
Endogenous opioid regulation of oxytocin release during parturition is reduced in ovariectomized rats.
Regulation (regulation) of Localization (release) of oxytocin associated with endogenous opioid
4) Confidence 0.62 Published 1993 Journal J. Endocrinol. Section Title Doc Link 7852884 Disease Relevance 0 Pain Relevance 0.44
The influences of opioids on oxytocin secretion and parturition were investigated in the rat.
Regulation (influences) of Localization (secretion) of oxytocin associated with opioid
5) Confidence 0.62 Published 1988 Journal Brain Res. Bull. Section Abstract Doc Link 2842005 Disease Relevance 0 Pain Relevance 0.53
The secretion of oxytocin (OXT) from the neurohypophysis is modulated by the actions of opioids acting via kappa-receptors.
Regulation (modulated) of Localization (secretion) of oxytocin in neurohypophysis associated with opioid
6) Confidence 0.61 Published 1994 Journal Neuroendocrinology Section Abstract Doc Link 7700499 Disease Relevance 0 Pain Relevance 0.63
We have investigated the influence of endogenous opioids on oxytocin secretion during pregnancy.
Spec (investigated) Regulation (influence) of Localization (secretion) of oxytocin associated with endogenous opioid
7) Confidence 0.61 Published 1993 Journal J. Neuroendocrinol. Section Abstract Doc Link 8100468 Disease Relevance 0 Pain Relevance 0.39
Endogenous opioid regulation of oxytocin secretion through pregnancy in the rat.
Regulation (regulation) of Localization (secretion) of oxytocin associated with endogenous opioid
8) Confidence 0.61 Published 1993 Journal J. Neuroendocrinol. Section Title Doc Link 8100468 Disease Relevance 0 Pain Relevance 0.80
In contrast to the paraventricular nucleus, naloxone did not alter swim-induced oxytocin release within the supraoptic nucleus either in virgin or pregnant rats.
Neg (not) Regulation (alter) of Localization (release) of oxytocin in supraoptic nucleus associated with narcan
9) Confidence 0.61 Published 2002 Journal Neuroscience Section Abstract Doc Link 12044477 Disease Relevance 0.28 Pain Relevance 0.47
In contrast, endogenous opioids were evidently not involved in the regulation of swim-induced oxytocin release within the supraoptic nucleus either in virgin or pregnant rats.
Regulation (regulation) of Localization (release) of oxytocin in supraoptic nucleus associated with endogenous opioid
10) Confidence 0.61 Published 2002 Journal Neuroscience Section Abstract Doc Link 12044477 Disease Relevance 0.16 Pain Relevance 0.42
Oxytocin secretion into blood in response to swim stress is differentially regulated by endogenous opioids in virgin and pregnant rats.
Regulation (regulated) of Localization (secretion) of Oxytocin in blood associated with stress and endogenous opioid
11) Confidence 0.61 Published 2002 Journal Neuroscience Section Abstract Doc Link 12044477 Disease Relevance 0.25 Pain Relevance 0.31
Endogenous opioid regulation of stress-induced oxytocin release within the hypothalamic paraventricular nucleus is reversed in late pregnancy: a microdialysis study.
Regulation (regulation) of Localization (release) of oxytocin in nucleus associated with stress and endogenous opioid
12) Confidence 0.61 Published 2002 Journal Neuroscience Section Title Doc Link 12044477 Disease Relevance 0.27 Pain Relevance 0.40
Endogenous opioid regulation of oxytocin and ACTH secretion during pregnancy and parturition.
Regulation (regulation) of Localization (secretion) of oxytocin associated with endogenous opioid
13) Confidence 0.61 Published 2001 Journal Prog. Brain Res. Section Title Doc Link 11589146 Disease Relevance 0.13 Pain Relevance 0.39
Morphine, given acutely, inhibits oxytocin secretion in adult female rats, but chronic intracerebroventricular infusion for five to six days induces tolerance and dependence in the mechanisms regulating oxytocin secretion.
Regulation (regulating) of Localization (secretion) of oxytocin associated with addiction, tolerance, intracerebroventricular and morphine
14) Confidence 0.60 Published 1990 Journal Neuroscience Section Abstract Doc Link 2174133 Disease Relevance 0 Pain Relevance 0.65
The data suggest that (i) dopamine stored in, and released from, the neural lobe may inhibit the secretion of oxytocin; (ii) the release of oxytocin may be continously controlled by an endogenous opioid peptide: opioid peptides may exert their effect via a disinhibitory phenomenon; they remove the inhibitory effect of dopamine on oxytocin release possibly by inhibiting the release of dopamine.
Regulation (controlled) of Localization (release) of oxytocin in neural lobe associated with dopamine, endogenous opioid and opioid
15) Confidence 0.60 Published 1980 Journal Neuroendocrinology Section Abstract Doc Link 7393404 Disease Relevance 0 Pain Relevance 0.74
The i.v. injection of naloxone resulted in a threefold increase in the secretion of oxytocin into portal blood in acutely hypophysectomized rats infused with morphine, but did not alter oxytocin secretion in vehicle-infused hypophysectomized rats.
Neg (not) Regulation (alter) of Localization (secretion) of oxytocin in blood associated with narcan and morphine
16) Confidence 0.59 Published 1990 Journal J. Endocrinol. Section Abstract Doc Link 2299273 Disease Relevance 0.06 Pain Relevance 1.28
These data show that, as for oxytocin release from the neurohypophysis into the systemic circulation, the mechanisms which regulate oxytocin release into the portal vessel blood can also be made morphine dependent.
Regulation (regulate) of Localization (release) of oxytocin in blood associated with morphine
17) Confidence 0.59 Published 1990 Journal J. Endocrinol. Section Abstract Doc Link 2299273 Disease Relevance 0.09 Pain Relevance 1.11
Temporal changes in the activity of endogenous opioid mechanisms regulating oxytocin secretion in saline-loaded rats.
Regulation (regulating) of Localization (secretion) of oxytocin associated with narcan and endogenous opioid
18) Confidence 0.57 Published 1987 Journal Neurosci. Lett. Section Title Doc Link 3696493 Disease Relevance 0 Pain Relevance 0.68
In these rats, naloxone increased oxytocin release in the septum threefold relative to control rats (p less than 0.02) but did not alter oxytocin release in hippocampus or nucleus of tractus solitarius.
Neg (not) Regulation (alter) of Localization (release) of oxytocin in nucleus associated with narcan and hippocampus
19) Confidence 0.55 Published 1992 Journal J. Neurosci. Section Abstract Doc Link 1545232 Disease Relevance 0.09 Pain Relevance 1.24
Dexamethasone differentially alters naltrexone effects on vasopressin and oxytocin release during tail electroshock.
Regulation (effects) of Localization (release) of oxytocin in tail associated with dexamethasone
20) Confidence 0.54 Published 1985 Journal Brain Res. Bull. Section Title Doc Link 4084815 Disease Relevance 0.12 Pain Relevance 0.58

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