INT78849

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Context Info
Confidence 0.53
First Reported 1998
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 4
Disease Relevance 2.31
Pain Relevance 0.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Pparg) signal transduction (Pparg) nucleus (Pparg)
enzyme binding (Pparg) DNA binding (Pparg) cytoplasm (Pparg)
Pparg (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cINOD 1 94.68 High High
Inflammation 1 94.04 High High
qutenza 1 87.60 High High
Cannabinoid 2 86.08 High High
Calcium channel 1 67.92 Quite High
tolerance 6 57.04 Quite High
cannabis 1 43.00 Quite Low
ischemia 4 5.00 Very Low Very Low Very Low
Angina 2 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Myocardial Infarction 32 99.88 Very High Very High Very High
Immunotherapy Of Cancer 1 99.28 Very High Very High Very High
Obesity 25 96.28 Very High Very High Very High
INFLAMMATION 4 94.48 High High
Diabetes Mellitus 62 91.08 High High
Bordatella Infection 1 84.56 Quite High
Disease 6 82.12 Quite High
Atherosclerosis 4 77.56 Quite High
Hypertension 4 63.60 Quite High
Insulin Resistance 16 62.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Of those individuals who developed an MI, the frequency of PPARG Ala12 allele carriers was significantly less than in the controls, with a
Transcription (frequency) of PPARG associated with myocardial infarction
1) Confidence 0.53 Published 2008 Journal PPAR Research Section Body Doc Link PMC2288645 Disease Relevance 1.01 Pain Relevance 0
to the PPARG Pro12 variant, the PPARG Ala12 variant has lower
Transcription (variant) of PPARG
2) Confidence 0.53 Published 2008 Journal PPAR Research Section Body Doc Link PMC2288645 Disease Relevance 0.83 Pain Relevance 0.03
In a reporter gene assay, cannabidiol increased the transcriptional activity of PPARgamma.
Transcription (activity) of PPARgamma
3) Confidence 0.50 Published 2009 Journal Eur. J. Pharmacol. Section Abstract Doc Link 19285060 Disease Relevance 0.18 Pain Relevance 0.21
Transcriptional activity of PPAR-gamma is induced by binding diverse ligands, including natural fatty acid derivatives, antidiabetic thiazolidinediones, and non-steroidal anti-inflammatory drugs.
Transcription (activity) of PPAR-gamma associated with inflammation and cinod
4) Confidence 0.39 Published 1998 Journal Nature Section Abstract Doc Link 9845075 Disease Relevance 0.29 Pain Relevance 0.14

General Comments

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