INT7885

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Context Info
Confidence 0.70
First Reported 1980
Last Reported 2010
Negated 10
Speculated 3
Reported most in Abstract
Documents 160
Total Number 166
Disease Relevance 14.36
Pain Relevance 87.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Oxt) extracellular region (Oxt) response to stress (Oxt)
cytoplasm (Oxt)
Anatomy Link Frequency
supraoptic nucleus 29
neurohypophysis 27
brain 16
neural lobe 14
plasma 13
Oxt (Rattus norvegicus)
Pain Link Frequency Relevance Heat
narcan 550 100.00 Very High Very High Very High
antagonist 302 100.00 Very High Very High Very High
Opioid 167 100.00 Very High Very High Very High
Hippocampus 52 100.00 Very High Very High Very High
noradrenaline 48 100.00 Very High Very High Very High
Enkephalin 28 100.00 Very High Very High Very High
Nucleus accumbens 1 100.00 Very High Very High Very High
tetrodotoxin 16 99.92 Very High Very High Very High
Morphine 198 99.88 Very High Very High Very High
Serotonin 4 99.84 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 122 100.00 Very High Very High Very High
Volume Depletion And Dehydration 10 100.00 Very High Very High Very High
Pressure And Volume Under Development 6 100.00 Very High Very High Very High
Pressure Volume 2 Under Development 2 100.00 Very High Very High Very High
Natriuresis 8 99.84 Very High Very High Very High
Pain 56 99.74 Very High Very High Very High
Hyponatremia 6 98.92 Very High Very High Very High
Body Weight 11 98.56 Very High Very High Very High
Hemorrhage 8 95.76 Very High Very High Very High
Urological Neuroanatomy 23 95.72 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Finally, pethidine depressed plasma oxytocin concentrations in rats given 2% saline to drink for 24 h to stimulate oxytocin secretion.
Positive_regulation (stimulate) of Localization (secretion) of oxytocin in plasma associated with algil
1) Confidence 0.70 Published 1991 Journal Am. J. Physiol. Section Abstract Doc Link 1877695 Disease Relevance 0 Pain Relevance 0.99
Naloxone did not potentiate oxytocin release in non-pregnant rats, or on Day 1 post partum, but did potentiate oxytocin release on Day 22 of pregnancy even in rats before the onset of parturition.
Positive_regulation (potentiate) of Localization (release) of oxytocin associated with narcan
2) Confidence 0.70 Published 1988 Journal J. Reprod. Fertil. Section Abstract Doc Link 3184053 Disease Relevance 0 Pain Relevance 0.60
Hence, the contractile activity of the uterus acts through positive feedback mechanisms during parturition to stimulate oxytocin neurons as well, and this further increases the secretion of oxytocin.
Positive_regulation (increases) of Localization (secretion) of oxytocin in uterus
3) Confidence 0.69 Published 2002 Journal Microsc. Res. Tech. Section Abstract Doc Link 11810714 Disease Relevance 0 Pain Relevance 0.11
A wide range of stressors stimulate oxytocin secretion in the rat.
Positive_regulation (stimulate) of Localization (secretion) of oxytocin
4) Confidence 0.69 Published 2008 Journal Prog. Brain Res. Section Abstract Doc Link 18655896 Disease Relevance 0.22 Pain Relevance 0.13
However, the principal stimulus for the increased oxytocin release is believed to originate, at least in part, from mechanical stimulation to the uterine cervix by fetuses near term, the resultant uterine contractile activity, and the fetal expulsion reflex.
Positive_regulation (increased) of Localization (release) of oxytocin in uterine
5) Confidence 0.69 Published 2002 Journal Microsc. Res. Tech. Section Abstract Doc Link 11810714 Disease Relevance 0 Pain Relevance 0.14
The increase in oxytocin secretion is presumably a consequence of releasing the oxytocin neurons from restraining inhibitory influences of endogenous opioids-, nitric oxide-, and GABA-containing neurons following declining blood levels of progesterone on the one hand and increasing levels of estrogen on the other during late pregnancy.
Positive_regulation (increase) of Localization (secretion) of oxytocin in neurons associated with gaba and endogenous opioid
6) Confidence 0.69 Published 2002 Journal Microsc. Res. Tech. Section Abstract Doc Link 11810714 Disease Relevance 0 Pain Relevance 0.14
Endogenous opioid regulation of stress-induced oxytocin release within the hypothalamic paraventricular nucleus is reversed in late pregnancy: a microdialysis study.
Positive_regulation (induced) of Localization (release) of oxytocin in nucleus associated with stress and endogenous opioid
7) Confidence 0.69 Published 2002 Journal Neuroscience Section Title Doc Link 12044477 Disease Relevance 0.27 Pain Relevance 0.40
In contrast to the paraventricular nucleus, naloxone did not alter swim-induced oxytocin release within the supraoptic nucleus either in virgin or pregnant rats.
Neg (not) Positive_regulation (induced) of Localization (release) of oxytocin in supraoptic nucleus associated with narcan
8) Confidence 0.69 Published 2002 Journal Neuroscience Section Abstract Doc Link 12044477 Disease Relevance 0.28 Pain Relevance 0.47
In summary, in pregnancy, basal and stress-induced oxytocin release within the paraventricular nucleus was not changed, whereas it was blunted within the supraoptic nucleus.
Positive_regulation (induced) of Localization (release) of oxytocin in supraoptic nucleus associated with stress
9) Confidence 0.69 Published 2002 Journal Neuroscience Section Abstract Doc Link 12044477 Disease Relevance 0.23 Pain Relevance 0.42
In contrast, endogenous opioids were evidently not involved in the regulation of swim-induced oxytocin release within the supraoptic nucleus either in virgin or pregnant rats.
Positive_regulation (induced) of Localization (release) of oxytocin in supraoptic nucleus associated with endogenous opioid
10) Confidence 0.69 Published 2002 Journal Neuroscience Section Abstract Doc Link 12044477 Disease Relevance 0.16 Pain Relevance 0.41
During pregnancy, emergence of endogenous opioid inhibition of oxytocin neurons is revealed by increased oxytocin secretion after administration of the opioid receptor antagonist, naloxone.
Positive_regulation (increased) of Localization (secretion) of oxytocin in neurons associated with antagonist, narcan, endogenous opioid and opioid receptor
11) Confidence 0.69 Published 2008 Journal Neurochem. Res. Section Abstract Doc Link 17960480 Disease Relevance 0.06 Pain Relevance 0.75
Here we show that prolonged estradiol-17beta and progesterone treatment (mimicking pregnancy levels) potentiates naloxone-induced oxytocin secretion in urethane-anesthetized virgin female rats.
Positive_regulation (induced) of Localization (secretion) of oxytocin associated with narcan
12) Confidence 0.69 Published 2008 Journal Neurochem. Res. Section Abstract Doc Link 17960480 Disease Relevance 0.08 Pain Relevance 0.87
Firing pattern analysis indicated that acute estradiol-17beta increased oxytocin secretion in dependent rats by increasing action potential clustering without an overall increase in firing rate.
Positive_regulation (increased) of Localization (secretion) of oxytocin associated with action potential
13) Confidence 0.69 Published 2008 Journal Neurochem. Res. Section Abstract Doc Link 17960480 Disease Relevance 0.09 Pain Relevance 0.95
Retrodialysis of naloxone into the supraoptic nucleus of morphine-dependent rats increased intranuclear oxytocin release by 56.5p +/- 12.7% whereas no change was seen in vehicle-treated dependent rats.
Positive_regulation (increased) of Localization (release) of oxytocin in supraoptic nucleus associated with narcan and morphine
14) Confidence 0.69 Published 1997 Journal Neuroreport Section Abstract Doc Link 9141071 Disease Relevance 0 Pain Relevance 0.75
Progress of parturition in the rat is optimal when there is increased oxytocin secretion, thus ensuring quick birth and otherwise risking adverse neonatal health.
Positive_regulation (increased) of Localization (secretion) of oxytocin
15) Confidence 0.69 Published 2001 Journal Prog. Brain Res. Section Abstract Doc Link 11589146 Disease Relevance 0.05 Pain Relevance 0.24
In late pregnant rats neuroendocrine stress responses, expressed as increased oxytocin secretion and activation of the hypothalamo-pituitary-adrenal axis, are attenuated.
Positive_regulation (increased) of Localization (secretion) of oxytocin in pituitary associated with stress
16) Confidence 0.68 Published 2006 Journal Neuroscience Section Abstract Doc Link 16310312 Disease Relevance 0.24 Pain Relevance 0
Increasing the calcium concentration in the medium from 1.2 to 3 mM caused only a marginal increase of the evoked oxytocin release.
Positive_regulation (increase) of Localization (release) of oxytocin
17) Confidence 0.68 Published 1987 Journal Brain Res. Section Abstract Doc Link 2829994 Disease Relevance 0 Pain Relevance 0.35
The i.v. injection of naloxone resulted in a threefold increase in the secretion of oxytocin into portal blood in acutely hypophysectomized rats infused with morphine, but did not alter oxytocin secretion in vehicle-infused hypophysectomized rats.
Positive_regulation (increase) of Localization (secretion) of oxytocin in blood associated with narcan and morphine
18) Confidence 0.67 Published 1990 Journal J. Endocrinol. Section Abstract Doc Link 2299273 Disease Relevance 0.06 Pain Relevance 1.31
Treatment of morphine-dependent rats with Nomega-nitro-l-arginine methyl ester also enhanced oxytocin secretion during naloxone-precipitated withdrawal.
Positive_regulation (enhanced) of Localization (secretion) of oxytocin associated with narcan, withdrawal and morphine
19) Confidence 0.67 Published 2003 Journal Eur. J. Neurosci. Section Abstract Doc Link 14622155 Disease Relevance 0.18 Pain Relevance 1.20
It is suggested that other types of non-noxious stimuli as well may increase oxytocin release.
Spec (may) Positive_regulation (increase) of Localization (release) of oxytocin
20) Confidence 0.67 Published 1997 Journal Acta Physiol Scand Suppl Section Abstract Doc Link 9401603 Disease Relevance 0.22 Pain Relevance 0.30

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