INT78850

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Context Info
Confidence 0.68
First Reported 1998
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 15
Total Number 15
Disease Relevance 5.83
Pain Relevance 5.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
neurons 4
IB4 2
PSP 2
Mouse 1
lumen 1
Asap1 (Mus musculus)
Pain Link Frequency Relevance Heat
intrathecal 39 99.54 Very High Very High Very High
Spinal cord 93 99.50 Very High Very High Very High
Pain 31 98.76 Very High Very High Very High
Antinociceptive 176 98.72 Very High Very High Very High
Antihyperalgesic 67 98.04 Very High Very High Very High
adenocard 202 97.76 Very High Very High Very High
antiallodynic 60 97.20 Very High Very High Very High
Neuropathic pain 14 91.12 High High
IPN 46 90.28 High High
ASIC 7 88.72 High High
Disease Link Frequency Relevance Heat
Stress 4 100.00 Very High Very High Very High
Pain 68 98.76 Very High Very High Very High
Hyperplasia 2 98.28 Very High Very High Very High
Nociception 101 97.28 Very High Very High Very High
Hypertrophy 2 94.84 High High
Neuropathic Pain 22 91.12 High High
Inflammatory Pain 46 90.28 High High
Pancreatitis 4 89.44 High High
Disease 9 88.16 High High
Fibrosis 2 87.84 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This purification strategy is based on the observation that recombinant rat PAP is secreted into the medium of baculovirus-infected insect cells [8].
Localization (secreted) of PAP
1) Confidence 0.68 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2617779 Disease Relevance 0 Pain Relevance 0
For our initial study, we used secretory isoforms of PAP that were purified from human seminal fluid and from bovine prostate [3].
Localization (secretory) of PAP in seminal fluid
2) Confidence 0.63 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2617779 Disease Relevance 0.44 Pain Relevance 0.82
The secretory isoforms of human, bovine and mouse PAP are ?
Localization (secretory) of PAP
3) Confidence 0.63 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2617779 Disease Relevance 0.42 Pain Relevance 0.79
In addition, we found that PAP was extensively co-localized with IB4 in axon terminals, located in lamina II of dorsal spinal cord.
Localization (localized) of PAP in IB4 associated with spinal cord
4) Confidence 0.63 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2800773 Disease Relevance 0 Pain Relevance 0.12
PAP is extensively co-localized with the ATP receptor P2X3 and is co-localized in 14.4% of all TRPV1+ DRG neurons in the mouse [3].
Localization (localized) of PAP in neurons
5) Confidence 0.59 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2617779 Disease Relevance 0.94 Pain Relevance 0.63
PAP is extensively co-localized with the ATP receptor P2X3 and is co-localized in 14.4% of all TRPV1+ DRG neurons in the mouse [3].
Localization (localized) of PAP in neurons
6) Confidence 0.59 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2617779 Disease Relevance 0.91 Pain Relevance 0.59
This was based on our observation that intrathecal injection of human (h)PAP protein (the secreted isoform) produced long-lasting antinociceptive, antihyperalgesic and antiallodynic effects that were dependent on A1-adenosine receptor (A1R) activation [3].
Localization (secreted) of PAP associated with antihyperalgesic, adenocard, antiallodynic, antinociceptive and intrathecal
7) Confidence 0.59 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2617779 Disease Relevance 0.45 Pain Relevance 0.75
In the dorsal spinal cord, there was extensive co-localization between PAP+ and IB4+ axon terminals in lamina II and partial overlap with CGRP+ axon terminals (Figure 3E–H).
Localization (localization) of PAP in IB4 associated with spinal cord
8) Confidence 0.58 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2800773 Disease Relevance 0.06 Pain Relevance 0.12
There are two isoforms of PAP, a secreted isoform and a transmembrane isoform [17], [19], [20].
Localization (secreted) of PAP
9) Confidence 0.58 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2800773 Disease Relevance 0.09 Pain Relevance 0.11
Mouse TM-PAP also dephosphorylated extracellular adenine nucleotides in a pH-dependent manner, although ATP was not a substrate for TM-PAP as it was for secretory PAP.
Localization (secretory) of PAP in Mouse
10) Confidence 0.55 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2617779 Disease Relevance 0.23 Pain Relevance 0.15
Although PAP is found in peptidergic and nonpeptidergic neurons of mice and rats, the percentage of PAP+ neurons that express these markers differs between species.
Localization (found) of PAP in neurons
11) Confidence 0.55 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2800773 Disease Relevance 0.22 Pain Relevance 0.17
In addition, we observed that NT5E was extensively co-localized with Prostatic acid phosphatase (PAP, also known as ACPP, Fluoride-resistant acid phosphatase or thiamine monophosphatase) in nociceptive neurons.
Localization (localized) of PAP in neurons associated with nociception
12) Confidence 0.53 Published 2010 Journal Mol Pain Section Body Doc Link PMC2874211 Disease Relevance 1.18 Pain Relevance 0.76
RESULTS: The SSPs are constitutively secreted, PAP in nanomolar, PSP/reg in micromolar concentrations.
Localization (secreted) of PAP in PSP
13) Confidence 0.33 Published 2004 Journal J. Surg. Res. Section Body Doc Link 15100001 Disease Relevance 0.35 Pain Relevance 0
BACKGROUND: PSP/reg and PAP are secretory stress proteins (SSP) and may be part of a protective mechanism.
Localization (secretory) of PAP in PSP associated with stress
14) Confidence 0.31 Published 2004 Journal J. Surg. Res. Section Abstract Doc Link 15100001 Disease Relevance 0.25 Pain Relevance 0.19
The administration of TE for 33 months caused the following changes: 1) significant increase in the weight of both lobes of the prostate, 2) cellular hypertrophy and increase in secretory material in the cells and in the lumen of the acini in the central and peripheral zones of the two lobes of the prostate, 3) cellular hyperplasia indicated by flow cytometric analysis of DNA content, 4) significant increase in the secretion of PAP and levels of estradiol, and 5) a marked increase in fibromuscular stroma in the central and peripheral zones of both the lobes of the prostate.
Localization (secretion) of PAP in lumen associated with hypertrophy and hyperplasia
15) Confidence 0.09 Published 1998 Journal Anat. Rec. Section Abstract Doc Link 9845214 Disease Relevance 0.27 Pain Relevance 0.09

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