INT78859

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Context Info
Confidence 0.47
First Reported 1998
Last Reported 2005
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.39
Pain Relevance 1.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Adam17) cell motility (Adam17) cell adhesion (Adam17)
plasma membrane (Adam17) cytoplasm (Adam17)
Anatomy Link Frequency
dorsal 1
Adam17 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 1 99.08 Very High Very High Very High
Spinal cord 3 97.56 Very High Very High Very High
intrathecal 2 97.24 Very High Very High Very High
Pain 7 91.88 High High
allodynia 4 82.52 Quite High
Inflammation 2 75.20 Quite High
cytokine 4 75.00 Quite High
Sciatic nerve 1 73.80 Quite High
Neuropathic pain 1 72.80 Quite High
aspirin 3 50.00 Quite Low
Disease Link Frequency Relevance Heat
Cancer 2 100.00 Very High Very High Very High
Necrosis 2 100.00 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 1 97.32 Very High Very High Very High
Pain 7 91.88 High High
Neuropathic Pain 6 82.52 Quite High
INFLAMMATION 2 75.20 Quite High
Disease 1 52.76 Quite High
Injury 2 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In a model of spinal immune activation by intrathecal HIV-1 gp120, we show that the anti-allodynic effects of minocycline are associated with decreased microglial activation, attenuated mRNA expression of interleukin-1beta (IL-1beta), tumor necrosis factor-alpha (TNF-alpha), IL-1beta-converting enzyme, TNF-alpha-converting enzyme, IL-1 receptor antagonist and IL-10 in lumbar dorsal spinal cord, and reduced IL-1beta and TNF-alpha levels in the CSF.
Transcription (expression) of TNF-alpha-converting in dorsal associated with necrosis, cancer, antagonist, acquired immune deficiency syndrome or hiv infection, spinal cord and intrathecal
1) Confidence 0.47 Published 2005 Journal Pain Section Abstract Doc Link 15836971 Disease Relevance 1.34 Pain Relevance 1.31
Agents that prevent TNFalpha mRNA transcription, e.g. lisophylline, PGE2, interleukin-10 and 8-BrcAMP, or TACE inhibitors, e.g.
Transcription (transcription) of TACE
2) Confidence 0.37 Published 1998 Journal Aliment. Pharmacol. Ther. Section Body Doc Link 9845404 Disease Relevance 0.05 Pain Relevance 0

General Comments

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