INT7886

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Context Info
Confidence 0.62
First Reported 1980
Last Reported 2010
Negated 26
Speculated 23
Reported most in Abstract
Documents 146
Total Number 169
Disease Relevance 14.53
Pain Relevance 72.99

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Avp) extracellular space (Avp) extracellular region (Avp)
response to stress (Avp) signal transducer activity (Avp)
Anatomy Link Frequency
blood 19
neural lobe 17
brain 14
nucleus 14
neurohypophysis 14
Avp (Rattus norvegicus)
Pain Link Frequency Relevance Heat
narcan 346 100.00 Very High Very High Very High
antagonist 211 100.00 Very High Very High Very High
agonist 139 100.00 Very High Very High Very High
Opioid 117 100.00 Very High Very High Very High
Morphine 101 100.00 Very High Very High Very High
Enkephalin 94 100.00 Very High Very High Very High
Endogenous opioid 93 100.00 Very High Very High Very High
Intracerebroventricular 77 100.00 Very High Very High Very High
opiate 54 100.00 Very High Very High Very High
Dynorphin 49 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Hypercapnia 1 100.00 Very High Very High Very High
Stress 76 99.68 Very High Very High Very High
Generalized Anxiety Disorder 18 99.68 Very High Very High Very High
Shock 24 99.48 Very High Very High Very High
Diuresis 5 99.44 Very High Very High Very High
Volume Depletion And Dehydration 47 98.80 Very High Very High Very High
Hypertension 16 98.76 Very High Very High Very High
Disease 2 98.62 Very High Very High Very High
Hyponatremia 85 98.26 Very High Very High Very High
Pain 25 97.80 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Opioid modulation of vasopressin secretion in conscious rats.
Regulation (modulation) of Localization (secretion) of vasopressin associated with opioid
1) Confidence 0.62 Published 1988 Journal Clin Exp Hypertens A Section Title Doc Link 3243002 Disease Relevance 0 Pain Relevance 0.82
To clarify the role of endogenous opioid peptides in the control of vasopressin (AVP) secretion, the effects of an endogenous kappa-agonist, leumorphin, derived from proenkephalin B and an opioid antagonist, naloxone, on AVP secretion were examined in conscious and freely moving rats.
Regulation (control) of Localization (secretion) of AVP associated with antagonist, narcan, agonist, endogenous opioid and opioid
2) Confidence 0.62 Published 1988 Journal Clin Exp Hypertens A Section Abstract Doc Link 3243002 Disease Relevance 0 Pain Relevance 0.62
The functional role of the nucleus tractus solitarius (NTS) in the regulation of arginine-vasopressin (AVP) release mediated by baroreceptor activation was investigated by examining the effects induced by the presynaptic alpha-adrenergic agonist clonidine.
Spec (investigated) Regulation (role) of Localization (release) of AVP in nucleus associated with agonist and clonidine
3) Confidence 0.62 Published 1990 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 1982697 Disease Relevance 0.08 Pain Relevance 0.30
However, no effect on AVP secretion was observed after iv injection of leumorphin (600 pmol).
Neg (no) Regulation (effect) of Localization (secretion) of AVP
4) Confidence 0.62 Published 1988 Journal Endocrinology Section Abstract Doc Link 3342763 Disease Relevance 0 Pain Relevance 0.22
These results indicate that leumorphin possesses a potent inhibitory effect on AVP secretion, suggesting its important role in the regulation of AVP secretion in the brain.
Regulation (regulation) of Localization (secretion) of AVP in brain
5) Confidence 0.62 Published 1988 Journal Endocrinology Section Abstract Doc Link 3342763 Disease Relevance 0 Pain Relevance 0.20
To elucidate the role of leumorphin, a kappa-agonist derived from proenkephalin-B (neoendorphin/dynorphin precursor), in the control of arginine vasopressin (AVP) secretion, we examined the effects of intracerebroventricular (icv) administration of leumorphin on AVP secretion under basal and stimulated conditions in conscious unrestrained rats.
Spec (examined) Regulation (effects) of Localization (secretion) of AVP associated with dynorphin, agonist and intracerebroventricular
6) Confidence 0.62 Published 1988 Journal Endocrinology Section Abstract Doc Link 3342763 Disease Relevance 0 Pain Relevance 0.22
These results indicate that endogenous opioid peptides exert a tonic inhibitory control on AVP secretion in rats.
Regulation (control) of Localization (secretion) of AVP associated with endogenous opioid
7) Confidence 0.62 Published 1989 Journal Endocrinology Section Abstract Doc Link 2546748 Disease Relevance 0 Pain Relevance 0.66
Effects of naloxone on vasopressin secretion in conscious rats: evidence for inhibitory role of endogenous opioid peptides in vasopressin secretion.
Regulation (Effects) of Localization (secretion) of vasopressin associated with endogenous opioid and narcan
8) Confidence 0.62 Published 1989 Journal Endocrinology Section Title Doc Link 2546748 Disease Relevance 0 Pain Relevance 0.71
The effects of naloxone, an opioid antagonist, on arginine vasopressin (AVP) secretion were examined in conscious unrestrained rats under both basal and stimulated conditions.
Spec (examined) Regulation (effects) of Localization (secretion) of AVP associated with antagonist, narcan and opioid
9) Confidence 0.62 Published 1989 Journal Endocrinology Section Abstract Doc Link 2546748 Disease Relevance 0 Pain Relevance 0.49
Kappa-opioid modulation of vasopressin secretion in conscious rats.
Regulation (modulation) of Localization (secretion) of vasopressin associated with narcan and opioid
10) Confidence 0.62 Published 1991 Journal J. Endocrinol. Section Title Doc Link 1648591 Disease Relevance 0 Pain Relevance 0.66
These results support the view that opiates modulate AVP secretion triggered by depolarization of nerve terminals by regulating Ca2+ fluxes.
Regulation (modulate) of Localization (secretion) of AVP in nerve associated with opiate
11) Confidence 0.62 Published 1984 Journal Neuroendocrinology Section Abstract Doc Link 6096748 Disease Relevance 0 Pain Relevance 0.51
The results indicate that NO acts as a stimulating factor to both the basal and reflex release of AVP, opposing the view that NO plays an inhibitory role in the regulation of AVP secretion.
Regulation (regulation) of Localization (secretion) of AVP
12) Confidence 0.62 Published 1996 Journal Neurosci. Lett. Section Abstract Doc Link 9014178 Disease Relevance 0.09 Pain Relevance 0.10
Effect of head-up tilt on vasopressin secretion and arterial pressure in anesthetized rats.
Regulation (Effect) of Localization (secretion) of vasopressin in head associated with anesthesia
13) Confidence 0.62 Published 1991 Journal Neuroendocrinology Section Title Doc Link 1922676 Disease Relevance 0.09 Pain Relevance 0.10
We examined the effects of gamma-aminobutyric acid (GABA) and naloxone, a potent opioid antagonist, on arginine vasopressin (AVP) secretion in conscious rats in order to study the relationship of GABA and endogenous opioid peptides in the regulation of AVP secretion.
Regulation (regulation) of Localization (secretion) of AVP associated with gaba, antagonist, endogenous opioid, narcan and opioid
14) Confidence 0.62 Published 1991 Journal Neuroendocrinology Section Abstract Doc Link 1766553 Disease Relevance 0 Pain Relevance 0.74
Although endogenous opioids are thought to be involved in the regulation of vasopressin secretion, their precise role is unclear.
Regulation (involved) of Localization (secretion) of vasopressin associated with endogenous opioid
15) Confidence 0.62 Published 1994 Journal Endocrinology Section Abstract Doc Link 8275962 Disease Relevance 0.08 Pain Relevance 0.35
The effect of the nonselective opioid antagonist diprenorphine on vasopressin secretion in the rat.
Regulation (effect) of Localization (secretion) of vasopressin associated with antagonist and opioid
16) Confidence 0.62 Published 1994 Journal Endocrinology Section Title Doc Link 8275962 Disease Relevance 0.21 Pain Relevance 0.45
Naloxone, an opiate receptor antagonist, was used to determine whether opioid peptides modulate release of oxytocin (OT) or vasopressin (AVP) in the rat after expulsion of the fetus, i.e. parturition.
Spec (whether) Regulation (modulate) of Localization (release) of AVP associated with antagonist, narcan, opiate and opioid
17) Confidence 0.61 Published 1986 Journal Brain Res. Section Abstract Doc Link 3756522 Disease Relevance 0 Pain Relevance 0.45
There are, however, no hypothalamic neuronal cell lines to study AVP gene regulation system, and it is not known whether RU 51599, regulates AVP secretion and biosynthesis under osmotic and non-osmotic stimulatory conditions of AVP release.
Spec (whether) Regulation (regulates) of Localization (secretion) of AVP in neuronal
18) Confidence 0.60 Published 1997 Journal Neuropeptides Section Abstract Doc Link 9413018 Disease Relevance 0.32 Pain Relevance 0.15
Naloxone and phenoxybenzamine failed to influence AVP release under both hypovolaemic and basal conditions.
Neg (failed) Regulation (influence) of Localization (release) of AVP associated with narcan
19) Confidence 0.60 Published 1991 Journal J. Physiol. Pharmacol. Section Abstract Doc Link 1686565 Disease Relevance 0.40 Pain Relevance 0.44
The effect of acute pharmacological manipulation of central serotonin neurotransmission on osmoregulated secretion of arginine vasopressin in the rat.
Regulation (effect) of Localization (secretion) of arginine vasopressin associated with serotonin
20) Confidence 0.60 Published 1993 Journal J. Endocrinol. Section Title Doc Link 8254296 Disease Relevance 0.26 Pain Relevance 0.56

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