INT78877

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Context Info
Confidence 0.75
First Reported 1998
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 10
Total Number 14
Disease Relevance 11.16
Pain Relevance 0.97

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

RNA binding (EWSR1) plasma membrane (EWSR1) nucleus (EWSR1)
intracellular (EWSR1) cytoplasm (EWSR1)
Anatomy Link Frequency
neural 1
EWSR1 (Homo sapiens)
Pain Link Frequency Relevance Heat
headache 4 97.64 Very High Very High Very High
antagonist 2 96.80 Very High Very High Very High
Pain 7 93.76 High High
backache 4 92.24 High High
agonist 33 92.04 High High
vincristine 1 86.24 High High
abdominal pain 6 82.48 Quite High
Central nervous system 1 71.96 Quite High
imagery 6 70.80 Quite High
cINOD 7 61.76 Quite High
Disease Link Frequency Relevance Heat
Clear Cell Sarcoma 140 99.84 Very High Very High Very High
Cancer 379 99.82 Very High Very High Very High
Disease 83 99.80 Very High Very High Very High
Communicable Diseases 5 99.20 Very High Very High Very High
Chondrosarcoma 27 99.08 Very High Very High Very High
Primitive Neuroectodermal Tumors 16 98.36 Very High Very High Very High
Headache 3 97.64 Very High Very High Very High
Bone Cancer 49 97.28 Very High Very High Very High
Brain Tumor 1 95.40 Very High Very High Very High
Dermatofibroma 5 94.64 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is characterized by the expression of MIC2, neural markers (Vimentin, S-100, Synaptophysin) and EWS/FLI1-translocation.
Gene_expression (expression) of EWS in neural
1) Confidence 0.75 Published 2006 Journal Urologe A Section Abstract Doc Link 16534648 Disease Relevance 1.05 Pain Relevance 0.14
MIC2 gene product expression and EWS/ETS gene rearrangement were detected in both case patients.
Gene_expression (detected) of EWS
2) Confidence 0.75 Published 2006 Journal Hum. Pathol. Section Abstract Doc Link 16784984 Disease Relevance 0.77 Pain Relevance 0.23
This translocation produces the chimeric transcript EWS/WT1 and the related WT1 protein, which can be detected by immunohistochemical method.
Gene_expression (produces) of EWS
3) Confidence 0.75 Published 2005 Journal Cytojournal Section Body Doc Link PMC555739 Disease Relevance 0.28 Pain Relevance 0
This product could lead to loss of the tumor suppressor effect of the WT1 gene as well as to an increase in EWS driven expression of growth factors normally repressed by WT1.
Gene_expression (expression) of EWS associated with cancer
4) Confidence 0.65 Published 1998 Journal Ann. Clin. Lab. Sci. Section Abstract Doc Link 9846206 Disease Relevance 0.87 Pain Relevance 0.08
This product could lead to loss of the tumor suppressor effect of the WT1 gene as well as to an increase in EWS driven expression of growth factors normally repressed by WT1.
Gene_expression (expression) of EWS associated with cancer
5) Confidence 0.65 Published 1999 Journal Ann. Clin. Lab. Sci. Section Abstract Doc Link 10074970 Disease Relevance 0.87 Pain Relevance 0.08
The fusion protein EWSRI/NR4A3 in extraskeletal chondrosarcomas activates PPAR?
Gene_expression (/) of EWS associated with chondrosarcoma
6) Confidence 0.65 Published 2010 Journal PPAR Research Section Body Doc Link PMC2825651 Disease Relevance 1.78 Pain Relevance 0.33
FISH for EWSR1 was performed on the same slide and showed rearrangement in most of the interphase nuclei with the 3' probe signal located on der(2)t(2;22) (Fig. 2b).
Gene_expression (performed) of EWSR1
7) Confidence 0.65 Published 2010 Journal Mol Cytogenet Section Body Doc Link PMC2908072 Disease Relevance 0.34 Pain Relevance 0
Cloning and sequencing of this product showed an in-frame fusion between EWSR1 exon 7 and CREB1 exon 7 (Fig. 3b).
Gene_expression (exon) of EWSR1
8) Confidence 0.65 Published 2010 Journal Mol Cytogenet Section Body Doc Link PMC2908072 Disease Relevance 0.30 Pain Relevance 0
We report the case of a small blue round cell tumor with an EWS gene rearrangement detected by fluorescent in situ hybridization (FISH) analysis that mimicked Ewing sarcoma, but with unusual histology and immunohistochemical features.
Gene_expression (detected) of EWS associated with cancer and bone cancer
9) Confidence 0.58 Published 2010 Journal Mol Cytogenet Section Abstract Doc Link PMC2908072 Disease Relevance 0.59 Pain Relevance 0
EWSR1-ATF1 and EWSR1-CREB1 are not exclusively found in CCS.
Neg (not) Gene_expression (found) of EWSR1 associated with clear cell sarcoma
10) Confidence 0.58 Published 2010 Journal Mol Cytogenet Section Body Doc Link PMC2908072 Disease Relevance 1.30 Pain Relevance 0
EWSR1-ATF1 and EWSR1-CREB1 are not exclusively found in CCS.
Neg (not) Gene_expression (found) of EWSR1 associated with clear cell sarcoma
11) Confidence 0.58 Published 2010 Journal Mol Cytogenet Section Body Doc Link PMC2908072 Disease Relevance 1.31 Pain Relevance 0
However, in developing EWS for MBDs and other infectious diseases, it is important to also include nonclimatic influences in the models and to make the models relevant to particular response decisions and to the needs of policy makers (WHO 2004).
Gene_expression (developing) of EWS associated with communicable diseases and disease
12) Confidence 0.41 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2599750 Disease Relevance 0.55 Pain Relevance 0
In 12 cases, in situ hybridization techniques were used to determine whether a rearrangement of the EWSR1 gene, required for a diagnosis of peripheral PNET, was present.
Gene_expression (rearrangement) of EWSR1 gene associated with primitive neuroectodermal tumors
13) Confidence 0.18 Published 2008 Journal Am. J. Surg. Pathol. Section Abstract Doc Link 18223324 Disease Relevance 0.85 Pain Relevance 0.12
Recently, Thomas et al [17] proposed that the protein product of the EWS gene interacts with Brn-3a cellular transcription factor via a direct protein-protein interaction.
Gene_expression (product) of EWS gene
14) Confidence 0.12 Published 2005 Journal Cytojournal Section Body Doc Link PMC555739 Disease Relevance 0.30 Pain Relevance 0

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