INT78879

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Context Info
Confidence 0.50
First Reported 1998
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 2.97
Pain Relevance 0.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

RNA binding (EWSR1) plasma membrane (EWSR1) nucleus (EWSR1)
intracellular (EWSR1) cytoplasm (EWSR1)
EWSR1 (Homo sapiens)
Pain Link Frequency Relevance Heat
headache 2 97.64 Very High Very High Very High
backache 2 92.24 High High
abdominal pain 2 82.96 Quite High
Central nervous system 1 71.96 Quite High
Disease Link Frequency Relevance Heat
Cancer 23 98.96 Very High Very High Very High
Bone Cancer 3 98.80 Very High Very High Very High
Headache 1 97.64 Very High Very High Very High
Brain Tumor 1 95.40 Very High Very High Very High
Low Back Pain 2 92.24 High High
Intestinal Obstruction 2 85.48 High High
Pressure And Volume Under Development 2 84.08 Quite High
Abdominal Pain 2 82.96 Quite High
Primitive Neuroectodermal Tumors 4 75.00 Quite High
Sarcoma 2 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Fluorescence in situ hybridization analysis using a DNA probe for the Ewing Sarcoma breakpoint region 1 (EWSR1) on chromosome 22g12 revealed a rearrangement of the EWSR1 locus.
Positive_regulation (rearrangement) of EWSR1 associated with bone cancer
1) Confidence 0.50 Published 2007 Journal Diagn. Cytopathol. Section Abstract Doc Link 17497665 Disease Relevance 0.51 Pain Relevance 0.08
MIC2 gene product expression and EWS/ETS gene rearrangement were detected in both case patients.
Positive_regulation (detected) of EWS
2) Confidence 0.49 Published 2006 Journal Hum. Pathol. Section Abstract Doc Link 16784984 Disease Relevance 0.77 Pain Relevance 0.23
This product could lead to loss of the tumor suppressor effect of the WT1 gene as well as to an increase in EWS driven expression of growth factors normally repressed by WT1.
Positive_regulation (increase) of EWS associated with cancer
3) Confidence 0.45 Published 1998 Journal Ann. Clin. Lab. Sci. Section Abstract Doc Link 9846206 Disease Relevance 0.82 Pain Relevance 0.08
This product could lead to loss of the tumor suppressor effect of the WT1 gene as well as to an increase in EWS driven expression of growth factors normally repressed by WT1.
Positive_regulation (increase) of EWS associated with cancer
4) Confidence 0.45 Published 1999 Journal Ann. Clin. Lab. Sci. Section Abstract Doc Link 10074970 Disease Relevance 0.87 Pain Relevance 0.08

General Comments

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