INT7888

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Context Info
Confidence 0.49
First Reported 1988
Last Reported 1992
Negated 2
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 0.25
Pain Relevance 2.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transducer activity (Oprl1, Avp) signal transduction (Avp) extracellular space (Avp)
extracellular region (Avp) plasma membrane (Oprl1) response to stress (Avp)
Anatomy Link Frequency
nerve 2
Oprl1 (Rattus norvegicus)
Avp (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 19 100.00 Very High Very High Very High
agonist 11 100.00 Very High Very High Very High
Kappa opioid receptor 3 100.00 Very High Very High Very High
opiate 2 100.00 Very High Very High Very High
narcan 10 99.66 Very High Very High Very High
MU agonist 10 95.44 Very High Very High Very High
Enkephalin 1 94.56 High High
Dynorphin 4 86.72 High High
Opioid 4 75.00 Quite High
opioid receptor 1 75.00 Quite High
Disease Link Frequency Relevance Heat
Diuresis 2 96.08 Very High Very High Very High
Volume Depletion And Dehydration 1 78.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
They also suggest that the kappa-opioid receptor plays an important role in regulating the secretion of AVP.
kappa-opioid receptor Regulation (regulating) of Localization (secretion) of AVP associated with kappa opioid receptor
1) Confidence 0.49 Published 1988 Journal Neuroendocrinology Section Abstract Doc Link 3251164 Disease Relevance 0.25 Pain Relevance 0.36
Two kappa-receptor antagonists, MR 2266 and diprenorphin, alone had no effect on vasopressin and oxytocin secretion from isolated nerve endings depolarized with potassium.
kappa-receptor Neg (no) Regulation (effect) of Localization (secretion) of vasopressin in nerve associated with antagonist
2) Confidence 0.13 Published 1992 Journal Exp Brain Res Section Abstract Doc Link 1358668 Disease Relevance 0 Pain Relevance 0.79
The effects of highly selective agonists and antagonists to the mu-, delta- and kappa-opioid receptor subtypes were studied on the vasopressin and oxytocin release in 24 h water-deprived male rats.
kappa-opioid receptor Regulation (effects) of Localization (release) of vasopressin associated with antagonist, kappa opioid receptor and agonist
3) Confidence 0.13 Published 1991 Journal Eur. J. Pharmacol. Section Abstract Doc Link 1665795 Disease Relevance 0 Pain Relevance 0.44
Naloxone, a nonselective opiate receptor antagonist, alone had no effect on vasopressin release but potentiated the electrically evoked release of oxytocin.
opiate receptor Neg (no) Regulation (effect) of Localization (release) of vasopressin associated with antagonist, narcan and opiate
4) Confidence 0.08 Published 1992 Journal Exp Brain Res Section Abstract Doc Link 1358668 Disease Relevance 0 Pain Relevance 1.04

General Comments

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