INT78895

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.46
First Reported 1998
Last Reported 2011
Negated 1
Speculated 0
Reported most in Body
Documents 30
Total Number 30
Disease Relevance 20.45
Pain Relevance 10.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (CCL5) aging (CCL5) extracellular region (CCL5)
cell-cell signaling (CCL5) cytoplasm (CCL5)
Anatomy Link Frequency
T cell 11
macrophage 3
monocyte 3
stromal cells 2
alveolar macrophages 1
CCL5 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 571 100.00 Very High Very High Very High
chemokine 405 100.00 Very High Very High Very High
rheumatoid arthritis 37 99.96 Very High Very High Very High
Neuropeptide 21 99.88 Very High Very High Very High
Arthritis 101 99.84 Very High Very High Very High
Inflammation 773 99.48 Very High Very High Very High
metalloproteinase 347 99.14 Very High Very High Very High
antagonist 79 99.08 Very High Very High Very High
substance P 52 99.00 Very High Very High Very High
Kappa opioid receptor 18 98.92 Very High Very High Very High
Disease Link Frequency Relevance Heat
Asthma 482 100.00 Very High Very High Very High
Rheumatoid Arthritis 37 99.96 Very High Very High Very High
Adenoma 36 99.84 Very High Very High Very High
Arthritis 25 99.84 Very High Very High Very High
Herpes Simplex Virus 715 99.72 Very High Very High Very High
INFLAMMATION 858 99.48 Very High Very High Very High
Polymyalgia Rheumatica 38 99.42 Very High Very High Very High
Rupture 7 99.40 Very High Very High Very High
Endometriosis 543 98.92 Very High Very High Very High
Chlamydia Infection 9 98.72 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
RANTES (regulated on activation, normal T cell expressed and secreted) is synthesized by endometrial and endometriotic stromal cells and circulates in peritoneal fluid.
Regulation (regulated) of RANTES in stromal cells associated with endometriosis
1) Confidence 0.46 Published 2002 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 12050207 Disease Relevance 0.33 Pain Relevance 0.12
Previous studies have demonstrated that RANTES (regulated on activation, normal T cell expressed and secreted) is synthesized by endometriotic stromal cells and circulates in peritoneal fluid, commensurate with the stage of endometriosis.
Regulation (regulated) of RANTES in T cell associated with endometriosis
2) Confidence 0.27 Published 2001 Journal Mol. Hum. Reprod. Section Abstract Doc Link 11160842 Disease Relevance 0.62 Pain Relevance 0.26
The levels of monocyte chemotactic protein-1 (MCP-1/CCL2) [7,8]; regulated on activation normal T-expressed and secreted (RANTES/CCL5) [21]; interleukin-8 (IL-8/CXCL8) [22,23]; and growth-regulated oncogene-?
Regulation (regulated) of RANTES in monocyte
3) Confidence 0.26 Published 2007 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1884154 Disease Relevance 1.11 Pain Relevance 0.54
Among the chemokines and their receptors that are arrayed disproportionately in glia and neurons are monocyte chemotactic protein-1/CC chemokine ligand 2 (CCL2), stromal cell-derived factor-1/CXC chemokine ligand 12 (CXCL12), fractalkine/CX3C chemokine ligand 1, interferon-gamma-inducible-protein-10/CXCL10, macrophage inflammatory protein-1alpha/CCL3, and regulated on activation, normal T cell expressed and secreted/CCL5.
Regulation (regulated) of CCL5 in monocyte associated with chemokine and inflammation
4) Confidence 0.26 Published 2005 Journal J. Leukoc. Biol. Section Abstract Doc Link 16204637 Disease Relevance 0.10 Pain Relevance 0.72
Expression of the inflammatory chemokines CCL5, CCL3 and CXCL10 in juvenile idiopathic arthritis, and demonstration of CCL5 production by an atypical subset of CD8+ T cells

This study focuses upon three chemokines, namely CCL5, CXCL10 and CCL3, which are potential novel therapeutic targets in arthritis.

Regulation (targets) of CCL5 in T cells associated with chemokine, inflammation, juvenile chronic polyarthritis and arthritis
5) Confidence 0.26 Published 2006 Journal Arthritis Res Ther Section Title Doc Link PMC1526593 Disease Relevance 0.64 Pain Relevance 0.55
Expression and modulation of ICAM-1, TNF-alpha and RANTES in human alveolar macrophages from lung-transplant recipients in vitro.
Regulation (modulation) of RANTES in alveolar macrophages
6) Confidence 0.25 Published 1998 Journal Transpl. Immunol. Section Title Doc Link 9848225 Disease Relevance 0.19 Pain Relevance 0.21
Antibodies to the beta-chemokine, RANTES (regulated on activation normal T-cell expressed and secreted), but not to various other cytokines, blocked U50488 inhibition by 56% suggesting that the anti-HIV-1 effect of U50488 involved, in part, the production of RANTES by MDM.
Regulation (regulated) of RANTES in T-cell associated with chemokine, acquired immune deficiency syndrome or hiv infection and cytokine
7) Confidence 0.24 Published 2001 Journal Drug Alcohol Depend Section Abstract Doc Link 11245971 Disease Relevance 0.84 Pain Relevance 0.58
Several inflammatory cytokine genes (CXCL1, CXCL2, CXCL3, CCL20, IL8, CCL23, CCL19, CCL21, CCL5) are dysregulated in adenomas.
Regulation (dysregulated) of CCL5 associated with adenoma, inflammation and cytokine
8) Confidence 0.23 Published 2011 Journal PLoS ONE Section Abstract Doc Link PMC3017541 Disease Relevance 1.83 Pain Relevance 0.44
-induced protein; JIA = juvenile idiopathic arthritis; MC = mononuclear cell; MIP = macrophage inflammatory protein; MTX = methotrexate; PB = peripheral blood; PCR = polymerase chain reaction; RA = rheumatoid arthritis; RANTES = regulated upon activation, normally t-cell expressed and secreted; SD = standard deviation; SF = synovial fluid.


Regulation (regulated) of RANTES in macrophage associated with inflammation, rheumatoid arthritis, methotrexate, juvenile chronic polyarthritis and arthritis
9) Confidence 0.23 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526593 Disease Relevance 0.75 Pain Relevance 0.60
To evaluate changes in platelet and chemokine function in patients undergoing percutaneous transluminal coronary angioplasty (PTCA), we measured and compared levels of PDMPs and a C-C chemokine, regulated on activation normally T-cell express and secreted (RANTES), by ELISA.
Regulation (regulated) of RANTES in platelet associated with chemokine and percutaneous transluminal coronary angioplasty
10) Confidence 0.22 Published 2003 Journal Thromb. Haemost. Section Abstract Doc Link 12624635 Disease Relevance 0.56 Pain Relevance 0.39
Long-term progestin treatment inhibits RANTES (regulated on activation, normal T cell expressed and secreted) gene expression in human endometrial stromal cells.
Regulation (regulated) of RANTES in stromal cells
11) Confidence 0.20 Published 2002 Journal J. Clin. Endocrinol. Metab. Section Title Doc Link 12050207 Disease Relevance 0.34 Pain Relevance 0.13
DPP IV can cleave substrates such as eotaxin, regulated on activation normal T cell expressed and secreted (RANTES, CCL5), neuropeptide Y (NPY), substance P, chromogranin B - derived peptides, and other airway peptides [32,33].
Regulation (regulated) of RANTES in T cell associated with neuropeptide and substance p
12) Confidence 0.20 Published 2010 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2877018 Disease Relevance 0.51 Pain Relevance 0.66
RESULTS: Production of interleukin (IL)-8, growth-related oncogene (GRO)-alpha, monocyte chemoattractant protein (MCP)-1, and regulated upon activation normal T-cell expressed and secreted (RANTES) protein by synovial fibroblasts was increased by TNF-alpha.
Regulation (regulated) of RANTES in monocyte
13) Confidence 0.17 Published 2005 Journal J. Oral Pathol. Med. Section Body Doc Link 15946184 Disease Relevance 0.17 Pain Relevance 0
We measured interleukin-1beta, interleukin-6, interferon-gamma inducible protein-10, RANTES (regulated upon activation, normal T-cell expressed and secreted), complement C3, mannose-binding lectin, complement C1q, soluble intercellular adhesion molecule-1, endothelin-1, nitric oxide, human lactoferrin, and hypocretin-1 levels in these samples.
Regulation (regulated) of RANTES in T-cell
14) Confidence 0.17 Published 2008 Journal Clin J Pain Section Body Doc Link 18180633 Disease Relevance 0.18 Pain Relevance 0
A methionine extension on the amino terminus of RANTES and the modified form of macrophage inflammatory protein-4, met-chemokine ?
Regulation (extension) of RANTES in macrophage associated with chemokine and inflammation
15) Confidence 0.14 Published 2002 Journal Respir Res Section Body Doc Link PMC64809 Disease Relevance 1.11 Pain Relevance 0.98
bp = base pair; CC = CC-chemokine; CCR5 = CC_chemokine receptor 5; GCA = giant cell arteritis; HLA = human leukocyte antigen; ICAM = intercellular adhesion molecule; IL = interleukin; IL-1 RN = IL-1 receptor antagonist; PMR = polymyalgia rheumatica; RA = rheumatoid arthritis; RANTES = regulated upon activation, normal T cell expressed and presumably secreted; TNF = tumor necrosis factor.



Regulation (regulated) of RANTES in T cell associated with chemokine, necrosis, polymyalgia rheumatica, cancer, antagonist, rheumatoid arthritis, adhesions and giant cell arteritis
16) Confidence 0.14 Published 2001 Journal Arthritis Res Section Body Doc Link PMC128892 Disease Relevance 1.57 Pain Relevance 0.23
, IL-4, IL-5, IL-8, RANTES and eotaxins, thought to be important in asthma pathogenesis, are regulated through activation of p38 MAPK. p38 MAPK can affect the transcription of these genes but also has major effects on mRNA stability.
Regulation (regulated) of RANTES associated with asthma
17) Confidence 0.13 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 0.90 Pain Relevance 0.44
Antibodies to the beta-chemokine, RANTES (regulated on activation normal T-cell expressed and secreted), but not to various other cytokines, blocked U50488 inhibition by 56% suggesting that the anti-HIV-1 effect of U50488 involved, in part, the production of RANTES by MDM.
Regulation (regulated) of beta-chemokine in T-cell associated with chemokine, acquired immune deficiency syndrome or hiv infection and cytokine
18) Confidence 0.11 Published 2001 Journal Drug Alcohol Depend Section Abstract Doc Link 11245971 Disease Relevance 0.84 Pain Relevance 0.58
Incubation with hTWEAK increased the production of prostaglandin E2, matrix metalloproteinase-1 (MMP-1), IL-6, and the chemokines IL-8, RANTES (regulated on activation, normal T expressed and secreted) and interferon-?
Regulation (regulated) of RANTES associated with chemokine and metalloproteinase
19) Confidence 0.10 Published 2002 Journal Arthritis Res Section Abstract Doc Link PMC83846 Disease Relevance 0.41 Pain Relevance 0.18
DPP IV can cleave substrates such as eotaxin, regulated on activation normal T cell expressed and secreted (RANTES, CCL5), neuropeptide Y (NPY), substance P, chromogranin B - derived peptides, and other airway peptides [32,33].
Regulation (regulated) of CCL5 in T cell associated with neuropeptide and substance p
20) Confidence 0.09 Published 2010 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2877018 Disease Relevance 0.51 Pain Relevance 0.66

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox