INT78898

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Context Info
Confidence 0.42
First Reported 1998
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 9
Total Number 11
Disease Relevance 5.70
Pain Relevance 3.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (CCL5) aging (CCL5) extracellular region (CCL5)
cell-cell signaling (CCL5) cytoplasm (CCL5)
Anatomy Link Frequency
T cells 6
fibroblasts 2
platelet 2
AMs 1
lung 1
CCL5 (Homo sapiens)
Pain Link Frequency Relevance Heat
chemokine 206 100.00 Very High Very High Very High
Morphine 18 100.00 Very High Very High Very High
dexamethasone 2 100.00 Very High Very High Very High
cINOD 6 99.66 Very High Very High Very High
Percutaneous transluminal coronary angioplasty 5 98.70 Very High Very High Very High
Arthritis 101 98.64 Very High Very High Very High
narcan 2 98.60 Very High Very High Very High
methotrexate 28 96.64 Very High Very High Very High
Inflammation 151 96.00 Very High Very High Very High
opioid receptor 9 93.68 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 148 99.54 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 207 99.32 Very High Very High Very High
Infection 59 99.04 Very High Very High Very High
Acid Reflux 18 98.96 Very High Very High Very High
Juvenile Chronic Polyarthritis 80 98.64 Very High Very High Very High
Pneumonia 1 96.00 Very High Very High Very High
Acute Coronary Syndrome 3 95.52 Very High Very High Very High
Dyspepsia 24 94.20 High High
Necrosis 9 90.92 High High
Cancer 12 90.56 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As a model for investigating anti-inflammatory drugs, we studied the effects of the cyclohexadepsipeptide antibiotic, fusafungine, and that of the glucocorticoid dexamethasone on the expression of ICAM-1, TNF-alpha and RANTES, induced in vitro by rIFN-gamma in human AMs freshly isolated from bronchoalveolar lavage fluid (BAL) obtained in lung-transplanted patients.
Regulation (effects) of in AMs Gene_expression (expression) of RANTES in lung associated with inflammation, cinod and dexamethasone
1) Confidence 0.42 Published 1998 Journal Transpl. Immunol. Section Abstract Doc Link 9848225 Disease Relevance 0.20 Pain Relevance 0.20
To investigate the differences in mRNA production of CCL5 seen between peripheral blood and synovial T cells, we further investigated the population producing CCL5 from the joints of patients with JIA by flow cytometric analysis.
Spec (investigate) Regulation (differences) of Gene_expression (production) of CCL5 in T cells associated with arthritis
2) Confidence 0.38 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526593 Disease Relevance 0.31 Pain Relevance 0.30
To investigate the differences in mRNA production of CCL5 seen between peripheral blood and synovial T cells, we further investigated the population producing CCL5 from the joints of patients with JIA by flow cytometric analysis.
Spec (investigated) Regulation (population) of Gene_expression (producing) of CCL5 in T cells associated with arthritis
3) Confidence 0.38 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526593 Disease Relevance 0.31 Pain Relevance 0.30
The inhibitory effects of morphine on RANTES production and on chemotaxis were blocked by naloxone and beta-funaltrexamine, indicating that morphine mediated its suppressive effects via activation of microglial p-opioid receptors.
Regulation (effects) of Gene_expression (production) of RANTES associated with narcan, opioid receptor and morphine
4) Confidence 0.24 Published 2000 Journal J. Psychopharmacol. (Oxford) Section Abstract Doc Link 11106302 Disease Relevance 0.07 Pain Relevance 0.97
To evaluate changes in platelet and chemokine function in patients undergoing percutaneous transluminal coronary angioplasty (PTCA), we measured and compared levels of PDMPs and a C-C chemokine, regulated on activation normally T-cell express and secreted (RANTES), by ELISA.
Regulation (regulated) of Gene_expression (express) of RANTES in platelet associated with chemokine and percutaneous transluminal coronary angioplasty
5) Confidence 0.22 Published 2003 Journal Thromb. Haemost. Section Abstract Doc Link 12624635 Disease Relevance 0.56 Pain Relevance 0.39
Three specific chemokines—RANTES, MIP1?
Regulation (specific) of Gene_expression (chemokines) of RANTES associated with chemokine
6) Confidence 0.13 Published 2003 Journal Biol Proced Online Section Body Doc Link PMC153847 Disease Relevance 0.90 Pain Relevance 0.44
The biological effects of statins on cholesterol metabolism, Rho GTPases activity, LFA-1/ICAM-1 function and CCR5/RANTES expression can disrupt several steps of the HIV-1 life cycle, and target cell membrane interaction.
Regulation (effects) of Gene_expression (expression) of RANTES associated with acquired immune deficiency syndrome or hiv infection
7) Confidence 0.12 Published 2009 Journal Trials Section Body Doc Link PMC2705367 Disease Relevance 0.89 Pain Relevance 0.03
The hamster anti-hTWEAK mAbs, BCB10 and BEB3, were tested for their effects on hTWEAK stimulation of IL-8, MMP-1, PGE2, IL-6, IP-10 and RANTES production by dermal fibroblasts.
Regulation (effects) of Gene_expression (production) of RANTES in fibroblasts
8) Confidence 0.10 Published 2002 Journal Arthritis Res Section Body Doc Link PMC83846 Disease Relevance 0 Pain Relevance 0.07
Statins could possibly act on distinct levels for controlling HIV-1 replication: a) by lowering cholesterol, they could slow down the cell cycle, modify several signalling pathways and diminish viral entry and budding; b) by inhibiting the prenylation of small GTPases, they could hinder cell movement and decrease expression or affinity level of immune molecules such as LFA-1 and ICAM-1, c) by modulating CCR5 and RANTES expression, they could hamper the infection of target cells by R5 tropic viruses, and d) by blocking LFA-1/ICAMs interaction, they could attenuate several components of inflammatory, immunologic and virological responses.
Regulation (modulating) of Gene_expression (expression) of RANTES associated with inflammation, acquired immune deficiency syndrome or hiv infection and infection
9) Confidence 0.07 Published 2009 Journal Trials Section Body Doc Link PMC2705367 Disease Relevance 1.24 Pain Relevance 0.12
Marked elevation of the levels of IL-8, MCP-1, and RANTES (regulated on activation normal T-cell expressed and presumably secreted) has been observed in the esophageal mucosa of patients with reflux esophagitis.
Regulation (regulated) of Gene_expression (levels) of RANTES in T-cell associated with acid reflux
10) Confidence 0.04 Published 2007 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2291500 Disease Relevance 1.23 Pain Relevance 0.29
Handling conflicts in EoL situations
Regulation (conflicts) of Gene_expression (situations) of EoL
11) Confidence 0.03 Published 2010 Journal Med Health Care Philos Section Body Doc Link PMC2949555 Disease Relevance 0 Pain Relevance 0

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