INT78899

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Context Info
Confidence 0.77
First Reported 1998
Last Reported 2010
Negated 6
Speculated 3
Reported most in Body
Documents 155
Total Number 158
Disease Relevance 84.02
Pain Relevance 55.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (CCL5) aging (CCL5) extracellular region (CCL5)
cell-cell signaling (CCL5) cytoplasm (CCL5)
Anatomy Link Frequency
T-cell 27
monocyte 9
fibroblasts 6
plasma 5
lymphocytes 4
CCL5 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 3523 100.00 Very High Very High Very High
chemokine 3161 100.00 Very High Very High Very High
cytokine 1821 100.00 Very High Very High Very High
metalloproteinase 360 100.00 Very High Very High Very High
agonist 188 100.00 Very High Very High Very High
Angina 47 100.00 Very High Very High Very High
rheumatoid arthritis 800 99.96 Very High Very High Very High
mu opioid receptor 4 99.96 Very High Very High Very High
Morphine 46 99.92 Very High Very High Very High
Neuropeptide 44 99.88 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 3869 100.00 Very High Very High Very High
Herpes Simplex Virus 480 100.00 Very High Very High Very High
Cv General 3 Under Development 46 100.00 Very High Very High Very High
Rheumatoid Arthritis 800 99.96 Very High Very High Very High
Endometriosis 571 99.84 Very High Very High Very High
Ovarian Cancer 85 99.84 Very High Very High Very High
Cold Sores 205 99.80 Very High Very High Very High
Schizophrenia 50 99.76 Very High Very High Very High
Juvenile Chronic Polyarthritis 1363 99.54 Very High Very High Very High
Polymyalgia Rheumatica 76 99.42 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The increase in RANTES gene expression in response to IL-1beta was confirmed by PCR and real-time PCR.
Gene_expression (expression) of RANTES
1) Confidence 0.77 Published 2004 Journal J. Oral Pathol. Med. Section Body Doc Link 15482330 Disease Relevance 0.08 Pain Relevance 0
Interleukin-1beta increases RANTES gene expression and production in synovial fibroblasts from human temporomandibular joint.
Gene_expression (expression) of RANTES in fibroblasts associated with snapping jaw
2) Confidence 0.77 Published 2004 Journal J. Oral Pathol. Med. Section Title Doc Link 15482330 Disease Relevance 0.19 Pain Relevance 0.29
We demonstrated expression of the human RANTES receptors CCR-1 and CCR-5 in U937 cells and peritoneal macrophages.
Gene_expression (expression) of RANTES in peritoneal macrophages
3) Confidence 0.76 Published 2001 Journal Mol. Hum. Reprod. Section Abstract Doc Link 11160842 Disease Relevance 0.65 Pain Relevance 0.28
Previous studies have demonstrated that RANTES (regulated on activation, normal T cell expressed and secreted) is synthesized by endometriotic stromal cells and circulates in peritoneal fluid, commensurate with the stage of endometriosis.
Gene_expression (synthesized) of RANTES in T cell associated with endometriosis
4) Confidence 0.76 Published 2001 Journal Mol. Hum. Reprod. Section Abstract Doc Link 11160842 Disease Relevance 0.63 Pain Relevance 0.27
The levels of monocyte chemotactic protein-1 (MCP-1/CCL2) [7,8]; regulated on activation normal T-expressed and secreted (RANTES/CCL5) [21]; interleukin-8 (IL-8/CXCL8) [22,23]; and growth-regulated oncogene-?
Gene_expression (expressed) of RANTES in monocyte
5) Confidence 0.75 Published 2007 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1884154 Disease Relevance 1.09 Pain Relevance 0.54
Chemokines, including CCL5, may also be presented upon, and produced by, endothelial cells, in particular during inflammation [50,51].
Gene_expression (produced) of CCL5 in endothelial cells associated with chemokine and inflammation
6) Confidence 0.75 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526593 Disease Relevance 0.63 Pain Relevance 0.35
In a set of 11 JIA patients tested (4 persistent oligoarticular, 4 extended oligoarticular and 3 polyarticular), CCL5 expression was measured within the CD8+CD28+ T cells in paired samples of blood and synovial fluid T cells.
Gene_expression (expression) of CCL5 in blood associated with arthritis
7) Confidence 0.75 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526593 Disease Relevance 0.22 Pain Relevance 0.11
Chemokines, including CCL5, may also be presented upon, and produced by, endothelial cells, in particular during inflammation [50,51].
Gene_expression (presented) of CCL5 in endothelial cells associated with chemokine and inflammation
8) Confidence 0.75 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526593 Disease Relevance 0.62 Pain Relevance 0.34
CCL5 was not detected in control PBMCs and was absent or only weakly detectable in patient PBMCs.
Neg (not) Gene_expression (detected) of CCL5
9) Confidence 0.75 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526593 Disease Relevance 0.46 Pain Relevance 0.38
Levels of CCL5, CCL3 and CXCL10 were measured in plasma and SF samples after only one thaw.
Gene_expression (Levels) of CCL5 in plasma
10) Confidence 0.75 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526593 Disease Relevance 0 Pain Relevance 0.18
Expression and modulation of ICAM-1, TNF-alpha and RANTES in human alveolar macrophages from lung-transplant recipients in vitro.
Gene_expression (Expression) of RANTES in alveolar macrophages
11) Confidence 0.73 Published 1998 Journal Transpl. Immunol. Section Title Doc Link 9848225 Disease Relevance 0.19 Pain Relevance 0.21
As a model for investigating anti-inflammatory drugs, we studied the effects of the cyclohexadepsipeptide antibiotic, fusafungine, and that of the glucocorticoid dexamethasone on the expression of ICAM-1, TNF-alpha and RANTES, induced in vitro by rIFN-gamma in human AMs freshly isolated from bronchoalveolar lavage fluid (BAL) obtained in lung-transplanted patients.
Gene_expression (expression) of RANTES in lung associated with inflammation, cinod and dexamethasone
12) Confidence 0.73 Published 1998 Journal Transpl. Immunol. Section Abstract Doc Link 9848225 Disease Relevance 0.19 Pain Relevance 0.19
Regulated upon activation normal T-cell expressed and secreted (RANTES) gene expression was confirmed by polymerase chain reaction (PCR) and real-time PCR.
Gene_expression (expression) of RANTES in T-cell
13) Confidence 0.67 Published 2004 Journal J. Oral Pathol. Med. Section Body Doc Link 15482330 Disease Relevance 0.09 Pain Relevance 0
Increased gene expression and protein production of RANTES in synovial fibroblasts, in response to IL-1beta, may play an important role in recruitment of inflammatory cells into synovium and progression of synovitis in TMD.


Gene_expression (production) of RANTES in fibroblasts
14) Confidence 0.67 Published 2004 Journal J. Oral Pathol. Med. Section Body Doc Link 15482330 Disease Relevance 0.06 Pain Relevance 0
In addition, its action via progesterone response element cis-elements, PR appeared to inhibit trans-activation of a nuclear factor-kappaB-responsive element, further suppressing RANTES expression.
Gene_expression (expression) of RANTES
15) Confidence 0.67 Published 2002 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 12050207 Disease Relevance 0.29 Pain Relevance 0.26
Prolonged treatment (8 d) with MPA resulted in 36% and 50% decreases in luciferase activity and RANTES protein production, respectively, whereas shorter treatment (2 or 4 d) with MPA had no significant effect.
Gene_expression (production) of RANTES
16) Confidence 0.67 Published 2002 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 12050207 Disease Relevance 0.37 Pain Relevance 0.14
Previous studies have demonstrated that RANTES (regulated on activation, normal T cell expressed and secreted) is synthesized by endometriotic stromal cells and circulates in peritoneal fluid, commensurate with the stage of endometriosis.
Gene_expression (synthesized) of RANTES in T cell associated with endometriosis
17) Confidence 0.66 Published 2001 Journal Mol. Hum. Reprod. Section Abstract Doc Link 11160842 Disease Relevance 0.63 Pain Relevance 0.27
Temporal monitoring by ELISA of CCL5, CCL18, and soluble CD40 ligand (sCD40) levels revealed a drop in CCL5 and sCD40L levels in all UAP patients from day 2 onward (CCL5 12.1 ng/mL, P<0.001; sCD40L 1.35 ng/mL, P<0.05), whereas elevated CCL18 levels were sustained for at least 2 days, then were decreased at 180 days after inclusion (34.5 ng/mL, P<0.001).
Gene_expression (levels) of CCL5
18) Confidence 0.66 Published 2007 Journal Circulation Section Body Doc Link 17909104 Disease Relevance 0.28 Pain Relevance 0
CC chemokine ligand-5 (CCL5/RANTES) and CC chemokine ligand-18 (CCL18/PARC) are specific markers of refractory unstable angina pectoris and are transiently raised during severe ischemic symptoms.
Gene_expression (raised) of CCL5 associated with chemokine and angina
19) Confidence 0.66 Published 2007 Journal Circulation Section Title Doc Link 17909104 Disease Relevance 0.39 Pain Relevance 0.81
Production of CCL5 by synovial fluid T cells
Gene_expression (Production) of CCL5 in synovial fluid
20) Confidence 0.65 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526593 Disease Relevance 0.34 Pain Relevance 0.33

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