INT78901

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Context Info
Confidence 0.78
First Reported 1998
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 67
Total Number 69
Disease Relevance 40.79
Pain Relevance 20.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (CCL5) aging (CCL5) extracellular region (CCL5)
cell-cell signaling (CCL5) cytoplasm (CCL5)
Anatomy Link Frequency
T cell 28
synovial fluid 3
platelets 3
monocyte 3
Plasma 2
CCL5 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 1744 100.00 Very High Very High Very High
chemokine 1224 100.00 Very High Very High Very High
cytokine 852 100.00 Very High Very High Very High
fibrosis 33 100.00 Very High Very High Very High
rheumatoid arthritis 230 99.96 Very High Very High Very High
Neuropeptide 16 99.88 Very High Very High Very High
dexamethasone 51 99.42 Very High Very High Very High
Osteoarthritis 78 99.24 Very High Very High Very High
substance P 17 99.00 Very High Very High Very High
antagonist 203 98.82 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 1943 100.00 Very High Very High Very High
Fibrosis 33 100.00 Very High Very High Very High
Malignant Neoplastic Disease 7 100.00 Very High Very High Very High
Rheumatoid Arthritis 231 99.96 Very High Very High Very High
Asthma 1240 99.90 Very High Very High Very High
Infection 259 99.74 Very High Very High Very High
Adhesions 186 99.72 Very High Very High Very High
Cancer 151 99.68 Very High Very High Very High
Herpes Simplex Virus 240 99.54 Very High Very High Very High
Rhinitis 63 99.46 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Synovial fluid T cells showed higher basal levels of CCL5 release in this assay, and a greatly increased release of the chemokine upon stimulation, which was also only partially blocked (40% inhibition compared to maximal release) by inhibition of new protein synthesis (Figure 4).


Localization (release) of CCL5 in T cells associated with chemokine
1) Confidence 0.78 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526593 Disease Relevance 0.05 Pain Relevance 0.14
This correlates with recent reports that CCL5 secretion from memory and effector CD8+ T cells is from stored granules, thought to be distinct from lysosomal secretory granules, and that this secretion of CCL5 is resistant to ER and Golgi blockade [36,37].
Localization (secretion) of CCL5 in T cells
2) Confidence 0.78 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526593 Disease Relevance 0.14 Pain Relevance 0.15
In parallel with the cell preparations, small volumes of PB or SF were used to prepare cell-free fluid (plasma or synovial fluid, respectively) using a protocol to minimise platelet release to prevent release of CCL5 from platelets [33].
Localization (release) of CCL5 in synovial fluid
3) Confidence 0.78 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526593 Disease Relevance 0 Pain Relevance 0.05
As expected, PB T cells showed low levels of secreted CCL5 without stimulation, and responded to stimulation by an increased release of CCL5 that was partially inhibited (33% inhibition compared to maximal release) by cyclohexamide (Figure 4).
Localization (release) of CCL5 in T cells
4) Confidence 0.78 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526593 Disease Relevance 0.06 Pain Relevance 0.13
This correlates with reports that the rapid secretion of CCL5 from memory and effector CD8+ T cells is from stored granules, which are thought to be a unique compartment, distinct from lysosomal secretory granules, and that this secretion is resistant to ER and Golgi blockade [36,37,40].
Localization (secretion) of CCL5 in T cells
5) Confidence 0.78 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526593 Disease Relevance 0.39 Pain Relevance 0.23
This correlates with recent reports that CCL5 secretion from memory and effector CD8+ T cells is from stored granules, thought to be distinct from lysosomal secretory granules, and that this secretion of CCL5 is resistant to ER and Golgi blockade [36,37].
Localization (secretion) of CCL5 in T cells
6) Confidence 0.78 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526593 Disease Relevance 0.15 Pain Relevance 0.16
Previous studies have demonstrated that RANTES (regulated on activation, normal T cell expressed and secreted) is synthesized by endometriotic stromal cells and circulates in peritoneal fluid, commensurate with the stage of endometriosis.
Localization (secreted) of RANTES in T cell associated with endometriosis
7) Confidence 0.74 Published 2001 Journal Mol. Hum. Reprod. Section Abstract Doc Link 11160842 Disease Relevance 0.63 Pain Relevance 0.27
Among the chemokines and their receptors that are arrayed disproportionately in glia and neurons are monocyte chemotactic protein-1/CC chemokine ligand 2 (CCL2), stromal cell-derived factor-1/CXC chemokine ligand 12 (CXCL12), fractalkine/CX3C chemokine ligand 1, interferon-gamma-inducible-protein-10/CXCL10, macrophage inflammatory protein-1alpha/CCL3, and regulated on activation, normal T cell expressed and secreted/CCL5.
Localization (secreted) of CCL5 in neurons associated with chemokine and inflammation
8) Confidence 0.73 Published 2005 Journal J. Leukoc. Biol. Section Abstract Doc Link 16204637 Disease Relevance 0.10 Pain Relevance 0.72
However, a significant proportion of CCL5+ cells within the synovial fluid were still CD28+ and CD45RA- (Figure 5b), while in PB of both patients and controls, the majority of CD8+CCL5+ T cells were CD28-CD45RA+.
Localization (proportion) of CCL5 in T cells
9) Confidence 0.72 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526593 Disease Relevance 0.16 Pain Relevance 0.14
In the same conditions, dexamethasone significantly inhibited the release both of TNF-alpha and RANTES by AMs, mainly acting at the mRNA level, but had no effect on ICAM-1 expression.
Localization (release) of RANTES in AMs associated with dexamethasone
10) Confidence 0.70 Published 1998 Journal Transpl. Immunol. Section Abstract Doc Link 9848225 Disease Relevance 0.37 Pain Relevance 0.34
Levels of CC chemokine ligand (CCL)-5 (also known as RANTES [regulated on activation, normally T-cell expressed, and secreted]; 32.7 versus 23.1 ng/mL, P=0.018) and CCL18 (also known as PARC [pulmonary and activation-regulated chemokine]; 104.4 versus 53.7 ng/mL, P=0.011) were significantly elevated in patients with refractory ischemic symptoms versus stabilized patients.
Localization (secreted) of RANTES in T-cell
11) Confidence 0.68 Published 2007 Journal Circulation Section Body Doc Link 17909104 Disease Relevance 0.35 Pain Relevance 0
The levels of monocyte chemotactic protein-1 (MCP-1/CCL2) [7,8]; regulated on activation normal T-expressed and secreted (RANTES/CCL5) [21]; interleukin-8 (IL-8/CXCL8) [22,23]; and growth-regulated oncogene-?
Localization (secreted) of RANTES in monocyte
12) Confidence 0.68 Published 2007 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1884154 Disease Relevance 1.09 Pain Relevance 0.53
For example, the chemokine CCL5 (also known as 'regulated upon activation, normally T cell expressed and secreted' (RANTES)) activates T cells when in high concentration through a tyrosine kinase pathway [13,14], leads to production of IFN?
Localization (secreted) of CCL5 in T cell associated with chemokine
13) Confidence 0.68 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526593 Disease Relevance 0.58 Pain Relevance 0.59
CCL5, which is 'presented' by endothelium or secreted in the perivascular microenvironment, may contribute significantly to a gradient of CCL5.
Localization (secreted) of CCL5 in endothelium
14) Confidence 0.68 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526593 Disease Relevance 0.69 Pain Relevance 0.42
To demonstrate the active secretion of this stored CCL5, we stimulated purified T cells from blood and synovial fluid (n = 4) for 6 hours using anti-CD3 and anti-CD28.
Localization (secretion) of CCL5 in blood
15) Confidence 0.68 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526593 Disease Relevance 0.13 Pain Relevance 0.10
As expected, PB T cells showed low levels of secreted CCL5 without stimulation, and responded to stimulation by an increased release of CCL5 that was partially inhibited (33% inhibition compared to maximal release) by cyclohexamide (Figure 4).
Localization (secreted) of CCL5 in T cells
16) Confidence 0.68 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526593 Disease Relevance 0.12 Pain Relevance 0.12
TNF-alpha production, but not RANTES release (measured by ELISA), was significantly inhibited. mRNA studies, by means of polymerase chain reaction amplification of complementary deoxyribonucleic acids (RT-PCR), showed no significant modification of mRNA levels, suggesting that fusafungine acts mainly at a post-transcriptional level.
Localization (release) of RANTES
17) Confidence 0.66 Published 1998 Journal Transpl. Immunol. Section Abstract Doc Link 9848225 Disease Relevance 0.21 Pain Relevance 0.25
Regulated upon activation normal T-cell expressed and secreted (RANTES) gene expression was confirmed by polymerase chain reaction (PCR) and real-time PCR.
Localization (secreted) of RANTES in T-cell
18) Confidence 0.61 Published 2004 Journal J. Oral Pathol. Med. Section Body Doc Link 15482330 Disease Relevance 0.09 Pain Relevance 0
These cells contain high levels of stored intracellular CCL5, and rapid release of CCL5 takes place on T cell stimulation, without requiring new protein synthesis.
Localization (release) of CCL5 in T cell
19) Confidence 0.59 Published 2006 Journal Arthritis Res Ther Section Abstract Doc Link PMC1526593 Disease Relevance 0.53 Pain Relevance 0.45
For example, the chemokine CCL5 (also known as 'regulated upon activation, normally T cell expressed and secreted' (RANTES)) activates T cells when in high concentration through a tyrosine kinase pathway [13,14], leads to production of IFN?
Localization (secreted) of RANTES in T cell associated with chemokine
20) Confidence 0.59 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526593 Disease Relevance 0.51 Pain Relevance 0.58

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