INT78912

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Context Info
Confidence 0.49
First Reported 1998
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 1.26
Pain Relevance 3.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Prf1) endosome (Prf1) extracellular region (Prf1)
cytoplasmic membrane-bounded vesicle (Prf1) plasma membrane (Prf1) molecular_function (Prf1)
Anatomy Link Frequency
arm 1
Prf1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 20 99.56 Very High Very High Very High
Neurotransmitter 24 99.48 Very High Very High Very High
cocaine 14 99.30 Very High Very High Very High
adenocard 24 98.90 Very High Very High Very High
Glutamate 18 95.52 Very High Very High Very High
gABA 8 94.52 High High
intrathecal 11 91.40 High High
opioid receptor 6 91.00 High High
agonist 12 89.16 High High
Dopamine 6 88.72 High High
Disease Link Frequency Relevance Heat
Hypoxia 14 96.96 Very High Very High Very High
Paralysis 3 93.28 High High
Attention Deficit Hyperactivity Disorder 7 90.40 High High
Cv Unclassified Under Development 16 88.24 High High
Neurodegenerative Disease 26 74.40 Quite High
Brain Injury 2 71.36 Quite High
INFLAMMATION 10 69.52 Quite High
Necrosis 2 67.96 Quite High
Cancer 6 67.60 Quite High
Targeted Disruption 14 29.76 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
After the introduction of the delay, controls continued to choose the CRF arm, but HPC lesioned rats switched their preference to the immediate PRF arm.
Positive_regulation (immediate) of PRF in arm
1) Confidence 0.49 Published 2008 Journal Behav Neurosci Section Body Doc Link PMC2671844 Disease Relevance 0.15 Pain Relevance 0
Latency of P1 was increased by lignocaine and by magnesium sulphate 12.3% (p < 0.05).
Positive_regulation (increased) of P1
2) Confidence 0.41 Published 1998 Journal Anaesthesia Section Abstract Doc Link 9849282 Disease Relevance 0.17 Pain Relevance 0.27
Exposure to both cocaine and morphine showed a significant increase in mu receptor density on P1 and P7.
Positive_regulation (increase) of P1 associated with morphine and cocaine
3) Confidence 0.24 Published 2006 Journal Life Sci. Section Abstract Doc Link 16242731 Disease Relevance 0 Pain Relevance 1.21
The morphine-treated group showed a significant increase in mu receptor binding on P1 and P7.
Positive_regulation (increase) of P1 associated with morphine
4) Confidence 0.21 Published 2006 Journal Life Sci. Section Abstract Doc Link 16242731 Disease Relevance 0 Pain Relevance 1.19
However, the actions of these neurotransmitters become evident only when activation of P1 receptors is impaired, suggesting a critical role for this receptor during hypoxic events.
Positive_regulation (activation) of P1 associated with neurotransmitter and hypoxia
5) Confidence 0.10 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072925 Disease Relevance 0.80 Pain Relevance 0.54
These nucleotides can be rapidly degraded in the extracellular space by ectoenzymes to ADP or UDP, subsequently activating distinct P2Y receptors, or be finally degraded to adenosine, which is known to induce physiological responses via activation of P1 G protein-coupled receptors [20] (Fig. 1).
Positive_regulation (activation) of P1 associated with adenocard
6) Confidence 0.10 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072925 Disease Relevance 0.14 Pain Relevance 0.24

General Comments

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