INT78913

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Context Info
Confidence 0.67
First Reported 1998
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 22
Total Number 22
Disease Relevance 5.95
Pain Relevance 5.82

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (ABCC1) small molecule metabolic process (ABCC1) Golgi apparatus (ABCC1)
nucleolus (ABCC1) ATPase activity (ABCC1) plasma membrane (ABCC1)
Anatomy Link Frequency
skeletal muscle myoblast 6
T98G 2
proximal 2
epithelial cells 2
MDCK 2
ABCC1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Glutamate 169 100.00 Very High Very High Very High
qutenza 19 99.34 Very High Very High Very High
methotrexate 12 98.96 Very High Very High Very High
cINOD 62 98.82 Very High Very High Very High
COX-2 inhibitor 55 98.40 Very High Very High Very High
palliative 1 93.72 High High
Versed 2 93.44 High High
vincristine 6 92.24 High High
Morphine 2 90.52 High High
Potency 23 89.52 High High
Disease Link Frequency Relevance Heat
Colon Cancer 30 100.00 Very High Very High Very High
Breast Cancer 10 100.00 Very High Very High Very High
Non-small-cell Lung Cancer 27 99.84 Very High Very High Very High
Cancer 266 99.46 Very High Very High Very High
Stress 17 97.28 Very High Very High Very High
Lung Cancer 63 96.80 Very High Very High Very High
Neurological Disease 9 96.80 Very High Very High Very High
Apoptosis 155 96.26 Very High Very High Very High
Targeted Disruption 89 93.20 High High
Disease 29 90.80 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, we show that expression of human OATP2B1 in human skeletal muscle myoblast cells by adenoviral vectors increases intracellular accumulation and toxicity of statins and such effects were abrogated when cells overexpressed MRP1.
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of MRP1 in skeletal muscle myoblast
1) Confidence 0.67 Published 2010 Journal Circ. Res. Section Body Doc Link 19940267 Disease Relevance 0.06 Pain Relevance 0
Here, we studied the effect of various NSAIDs on MTX transport in membrane vesicles isolated from cells overexpressing the proximal tubular apical efflux transporters human multidrug resistance protein (MRP) 2/ABCC2 and MRP4/ABCC4.
Positive_regulation (overexpressing) of Gene_expression (overexpressing) of MRP in proximal associated with cinod and methotrexate
2) Confidence 0.67 Published 2007 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 17005917 Disease Relevance 0.32 Pain Relevance 0.91
Suppression of ROS formation by antioxidant N-acetylcysteine (NAC) downregulated the induction of MRP1 and MRP3 expression.
Positive_regulation (induction) of Gene_expression (expression) of MRP1
3) Confidence 0.62 Published 2002 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 11820781 Disease Relevance 0.66 Pain Relevance 0.38
In this study, we reported that among the six members of the multidrug resistance protein gene (MRP1 to MRP6) family which encode membrane transporters for a diverse group of antitumor agents, expression of MRP1 and MRP3 but not the others in human colorectal cancer cell lines was induced by sulindac.
Positive_regulation (induced) of Gene_expression (expression) of MRP1 associated with colon cancer
4) Confidence 0.62 Published 2002 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 11820781 Disease Relevance 0.66 Pain Relevance 0.46
Also, capsaicin, daidzein, piperine and sesamin increased significantly the mRNA expression of MRP1 or MRP3.
Positive_regulation (increased) of Gene_expression (expression) of MRP1 associated with qutenza
5) Confidence 0.49 Published 2010 Journal Biol. Pharm. Bull. Section Abstract Doc Link 20118549 Disease Relevance 0 Pain Relevance 0.31
In an in vitro model of differentiated, primary human skeletal muscle myoblast cells, we demonstrate basal membrane expression and drug efflux activity of MRP1, which contributes to reducing intracellular statin accumulation.
Positive_regulation (demonstrate) of Gene_expression (expression) of MRP1 in skeletal muscle myoblast
6) Confidence 0.49 Published 2010 Journal Circ. Res. Section Body Doc Link 19940267 Disease Relevance 0.07 Pain Relevance 0
In an in vitro model of differentiated, primary human skeletal muscle myoblast cells, we demonstrate basal membrane expression and drug efflux activity of MRP1, which contributes to reducing intracellular statin accumulation.
Positive_regulation (basal) of Gene_expression (expression) of MRP1 in skeletal muscle myoblast
7) Confidence 0.49 Published 2010 Journal Circ. Res. Section Body Doc Link 19940267 Disease Relevance 0.07 Pain Relevance 0
Caco-2 [36] or MDR1-MDCK (Madin Darby canine kidney cells transfected with the human multidrug resistance MDR1 gene) [37] cell monolayers were grown to confluence on collagen-coated, microporous, polycarbonate membranes in 12-well microtitre plates.
Positive_regulation (transfected) of Gene_expression (transfected) of multidrug resistance in MDCK
8) Confidence 0.49 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC3006138 Disease Relevance 0 Pain Relevance 0
Moreover, it has been suggested that COX-2 inhibitors may contribute to maintain high levels of chemotherapeutics in tumor tissues by preventing the overexpression of the multidrug resistance protein MDR1/P-gp.
Positive_regulation (overexpression) of Gene_expression (overexpression) of multidrug resistance protein MDR1 associated with cancer and cox-2 inhibitor
9) Confidence 0.49 Published 2005 Journal Brain Res. Brain Res. Rev. Section Abstract Doc Link 15850674 Disease Relevance 0.88 Pain Relevance 0.58
P-glycoprotein (Pgp), multidrug resistance proteins (MRPs) and breast cancer resistance protein (BCRP) [45,48,50-53], that are overexpressed by the endothelial or epithelial cells of these barriers [52].
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of multidrug resistance in epithelial cells associated with breast cancer
10) Confidence 0.45 Published 2010 Journal Part Fibre Toxicol Section Body Doc Link PMC2847536 Disease Relevance 0.17 Pain Relevance 0.23
Furthermore, the expression of a variety of drug transporters (ABCB1, ABCG2, ABCC1-5) as well as the human transferrin receptor was demonstrated on the mRNA level.
Positive_regulation (demonstrated) of Gene_expression (expression) of ABCC1-5
11) Confidence 0.45 Published 2008 Journal J. Neurochem. Section Abstract Doc Link 19013850 Disease Relevance 0 Pain Relevance 0.14
RESULTS: Sulindac was shown to significantly potentiate the tumour growth inhibitor activity of doxorubicin in this MRP-1-overexpressing human tumour xenograft model.
Positive_regulation (overexpressing) of Gene_expression (overexpressing) of MRP-1-overexpressing
12) Confidence 0.44 Published 2004 Journal Anticancer Res. Section Body Doc Link 15152944 Disease Relevance 0.07 Pain Relevance 0
In contrast, a multidrug resistance (MDR) phenotype due to expression of the multidrug resistance-associated protein (MRP) is most prominent in T98G cells and is amenable to modulation by indomethacin, suggesting that inhibition of MRP is at least in partly responsible for the potentiation of doxorubicin and vincristine cytotoxicity by NSAID.
Positive_regulation (due) of Gene_expression (expression) of resistance-associated protein in T98G associated with vincristine and cinod
13) Confidence 0.34 Published 1999 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 10364464 Disease Relevance 0.27 Pain Relevance 1.06
However, in the HL60/ADR and COR L23R cell lines, in which multidrug resistance is due to overexpression of the multidrug resistance-associated protein MRP, a significant increase in cytotoxicity was observed in the presence of the active NSAIDs.
Positive_regulation (overexpression) of Gene_expression (overexpression) of MRP associated with cinod
14) Confidence 0.30 Published 1998 Journal Eur. J. Cancer Section Abstract Doc Link 9849488 Disease Relevance 0.32 Pain Relevance 0.65
GalA-MRP produced maximum increase in the CT response between pH 6 and 7.
Positive_regulation (increase) of Gene_expression (produced) of MRP
15) Confidence 0.23 Published 2008 Journal Chemical Senses Section Body Doc Link PMC2533421 Disease Relevance 0.14 Pain Relevance 0.13
In comparison to RTX (0.0000063%) and CAP (0.0012%) (Lyall et al. 2004, 2005c), GalA-MRP and GluNH2-MRP produced maximum increase in the CT response at 0.25%.
Positive_regulation (increase) of Gene_expression (produced) of MRP
16) Confidence 0.23 Published 2008 Journal Chemical Senses Section Body Doc Link PMC2533421 Disease Relevance 0 Pain Relevance 0.03
This is further supported by the observations that GalA-MRP produced increase in human sensory salt taste evaluation in the presence of amiloride (Figure 8B).
Positive_regulation (increase) of Gene_expression (produced) of MRP
17) Confidence 0.23 Published 2008 Journal Chemical Senses Section Body Doc Link PMC2533421 Disease Relevance 0 Pain Relevance 0.09
It is likely that Xyl-MRP and IMP produce their effects on the CT response to MSG by acting on the T1R3 part of the umami taste receptor (T1R1 + T1R3).
Positive_regulation (acting) of Gene_expression (produce) of MRP associated with glutamate
18) Confidence 0.20 Published 2008 Journal Chemical Senses Section Body Doc Link PMC2533421 Disease Relevance 0.17 Pain Relevance 0.42
In comparison, using the magnitude scale GalA-MRP produced its maximum increase in salt perception at 0.01%.
Positive_regulation (increase) of Gene_expression (produced) of MRP
19) Confidence 0.20 Published 2008 Journal Chemical Senses Section Body Doc Link PMC2533421 Disease Relevance 0.06 Pain Relevance 0.11
The GalA-MRP and GlcNH2-MRP produced their maximum increase in salt perception using quantitative descriptive analysis at 0.0005% and 0.002%, respectively.
Positive_regulation (increase) of Gene_expression (produced) of MRP
20) Confidence 0.20 Published 2008 Journal Chemical Senses Section Body Doc Link PMC2533421 Disease Relevance 0.07 Pain Relevance 0.12

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