INT78914

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Context Info
Confidence 0.67
First Reported 1998
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 19
Total Number 19
Disease Relevance 7.99
Pain Relevance 5.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (ABCC1) small molecule metabolic process (ABCC1) Golgi apparatus (ABCC1)
nucleolus (ABCC1) ATPase activity (ABCC1) plasma membrane (ABCC1)
Anatomy Link Frequency
liver 2
colon 1
lung 1
H460 1
ABCC1 (Homo sapiens)
Pain Link Frequency Relevance Heat
COX2 2 100.00 Very High Very High Very High
Paracetamol 29 99.72 Very High Very High Very High
qutenza 20 98.20 Very High Very High Very High
cINOD 26 97.72 Very High Very High Very High
tolerance 1 92.40 High High
Inflammation 6 88.96 High High
Versed 2 84.52 Quite High
palliative 2 83.68 Quite High
diclofenac 1 81.76 Quite High
Morphine 1 81.60 Quite High
Disease Link Frequency Relevance Heat
Breast Cancer 6 100.00 Very High Very High Very High
Biliary Liver Cirrhosis 16 99.84 Very High Very High Very High
Disease 62 99.72 Very High Very High Very High
Overdose 10 99.52 Very High Very High Very High
Infection 22 99.20 Very High Very High Very High
Lung Cancer 24 99.04 Very High Very High Very High
Adenocarcinoma 4 98.86 Very High Very High Very High
Asthma 2 98.78 Very High Very High Very High
INFLAMMATION 17 97.60 Very High Very High Very High
Cancer 41 96.48 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In breast adenocarcinoma cell lines, activation of the EGFR pathway is linked to activation of the multidrug resistance transporter family.61 EGFR resistance may also be due to mutations in the receptor protein itself.
Positive_regulation (activation) of multidrug resistance associated with adenocarcinoma
1) Confidence 0.67 Published 2009 Journal OncoTargets and therapy Section Body Doc Link PMC2886327 Disease Relevance 0.62 Pain Relevance 0.03
Protein levels of MRP4, MRP5, BCRP, and P-gp were increased in both disease states, with MRP1 and MRP3 protein also being induced in PBC.
Positive_regulation (induced) of MRP1 associated with biliary liver cirrhosis and disease
2) Confidence 0.67 Published 2007 Journal Drug Metab. Dispos. Section Abstract Doc Link 17627974 Disease Relevance 1.37 Pain Relevance 0.57
Compared with normal liver specimens, MRP1 and MRP4 mRNA levels were elevated after APAP overdose and in PBC.
Positive_regulation (elevated) of MRP1 in liver associated with biliary liver cirrhosis, paracetamol and overdose
3) Confidence 0.67 Published 2007 Journal Drug Metab. Dispos. Section Abstract Doc Link 17627974 Disease Relevance 1.20 Pain Relevance 0.54
Induction of multidrug resistance proteins MRP1 and MRP3 and gamma-glutamylcysteine synthetase gene expression by nonsteroidal anti-inflammatory drugs in human colon cancer cells.
Positive_regulation (Induction) of MRP1 in colon associated with inflammation, colon cancer, cinod and cox2
4) Confidence 0.62 Published 2002 Journal Biochem. Biophys. Res. Commun. Section Title Doc Link 11820781 Disease Relevance 0.64 Pain Relevance 0.56
NCI H460 cells expressed MRP-1 protein (by Western blot) and also the toxicity of doxorubicin (a substrate of MRP-1) could be potentiated in this line using non-toxic concentrations of the MRP-1 substrate/inhibitor sulindac.
Positive_regulation (potentiated) of MRP-1 in H460
5) Confidence 0.50 Published 2004 Journal Anticancer Res. Section Body Doc Link 15152944 Disease Relevance 0.09 Pain Relevance 0
In LS-180V cells, significant increases in mRNA levels of multi-drug resistance associated protein 1 (MRP1) or MRP3 were observed on pretreatment with capsaicin, daidzein, piperine and sesamin.
Positive_regulation (increases) of multi-drug resistance associated protein 1 associated with qutenza
6) Confidence 0.45 Published 2010 Journal Biol. Pharm. Bull. Section Abstract Doc Link 20118549 Disease Relevance 0.06 Pain Relevance 0.44
In LS-180V cells, significant increases in mRNA levels of multi-drug resistance associated protein 1 (MRP1) or MRP3 were observed on pretreatment with capsaicin, daidzein, piperine and sesamin.
Positive_regulation (increases) of MRP1 associated with qutenza
7) Confidence 0.45 Published 2010 Journal Biol. Pharm. Bull. Section Abstract Doc Link 20118549 Disease Relevance 0.06 Pain Relevance 0.44
AMLs of older subjects display several biological overlaps with secondary AMLs including multilineage involvement, phenotype, unfavorable cytogenetics and elevated activity of multidrug resistance genes.
Positive_regulation (elevated) of multidrug resistance
8) Confidence 0.45 Published 2001 Journal Crit. Rev. Oncol. Hematol. Section Abstract Doc Link 11500268 Disease Relevance 0.53 Pain Relevance 0.13
Suppression of ROS formation by antioxidant N-acetylcysteine (NAC) downregulated the induction of MRP1 and MRP3 expression.
Positive_regulation (induction) of MRP1
9) Confidence 0.45 Published 2002 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 11820781 Disease Relevance 0.66 Pain Relevance 0.38
ABCB1, ABCG2 and transferrin receptor proteins were detected and functional activity of ABCB1, ABCG2 and the ABCC family was quantified in efflux experiments.
Positive_regulation (activity) of ABCC
10) Confidence 0.39 Published 2008 Journal J. Neurochem. Section Abstract Doc Link 19013850 Disease Relevance 0 Pain Relevance 0.12
However, in the HL60/ADR and COR L23R cell lines, in which multidrug resistance is due to overexpression of the multidrug resistance-associated protein MRP, a significant increase in cytotoxicity was observed in the presence of the active NSAIDs.
Positive_regulation (increase) of MRP associated with cinod
11) Confidence 0.30 Published 1998 Journal Eur. J. Cancer Section Abstract Doc Link 9849488 Disease Relevance 0.32 Pain Relevance 0.65
Thus, at 45 °C both the GalA-MRP–induced increase in the Bz-insensitive NaCl CT response and the GalA-MRP–induced increase in the salt taste perception in humans are most likely due to the amiloride- and Bz-insensitive salt taste receptor and not due to the amiloride-sensitive epithelial Na+ channels.
Positive_regulation (increase) of MRP
12) Confidence 0.22 Published 2008 Journal Chemical Senses Section Body Doc Link PMC2533421 Disease Relevance 0 Pain Relevance 0.10
Similarly, the phasic CT response was not affected with increasing GalA-MRP concentrations relative to N + Bz.
Positive_regulation (increasing) of MRP
13) Confidence 0.20 Published 2008 Journal Chemical Senses Section Body Doc Link PMC2533421 Disease Relevance 0.40 Pain Relevance 0.03
The increase in the Bz-insensitive NaCl CT response by GalA-MRP and ethanol were additive (Figure 3D), suggesting that ethanol and GalA-MRP bind to different intracellular-binding sites on the TRPV1t receptor.
Positive_regulation (increase) of MRP
14) Confidence 0.20 Published 2008 Journal Chemical Senses Section Body Doc Link PMC2533421 Disease Relevance 0 Pain Relevance 0.06
It has been found that, in contrast to infection with Sb-sensitive L. donovani isolates, infection with Sb-resistant L. donovani isolates upregulates the multidrug resistance-associated protein 1 (MRP1) and the permeability glycoprotein (P-gp) in host cells, thus inhibiting intracellular drug accumulation by decreasing antimony influx [31, 34, 35].
Positive_regulation (upregulates) of MRP1 associated with infection
15) Confidence 0.14 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2771279 Disease Relevance 0.29 Pain Relevance 0
It has been found that, in contrast to infection with Sb-sensitive L. donovani isolates, infection with Sb-resistant L. donovani isolates upregulates the multidrug resistance-associated protein 1 (MRP1) and the permeability glycoprotein (P-gp) in host cells, thus inhibiting intracellular drug accumulation by decreasing antimony influx [31, 34, 35].
Positive_regulation (upregulates) of multidrug resistance-associated protein 1 associated with infection
16) Confidence 0.14 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2771279 Disease Relevance 0.29 Pain Relevance 0
Since synthetic glucocorticoids have found extensive use as anti-inflammatory drugs, also in the inhaled form in the treatment of asthma, lung cancer is potentially highly prone to transcriptional induction of multidrug resistance proteins by these steroids.
Positive_regulation (induction) of multidrug resistance in lung associated with asthma, lung cancer, inflammation and cinod
17) Confidence 0.10 Published 2005 Journal J. Steroid Biochem. Mol. Biol. Section Abstract Doc Link 15979871 Disease Relevance 0.47 Pain Relevance 0.14
There are numerous non-synonymous (i.e. protein sequence changing) polymorphisms in MDR1 and in other efflux transporters, such as breast cancer resistance protein (BRCP) and in the multidrug resistance-associated proteins (MRPs) (Table 2).


Positive_regulation (polymorphisms) of multidrug resistance-associated associated with breast cancer
18) Confidence 0.04 Published 2008 Journal Eur J Clin Pharmacol Section Body Doc Link PMC2235910 Disease Relevance 0.10 Pain Relevance 0
In the livers of MCD rats, there were striking increases in both mRNA and protein levels of multidrug resistance-associated protein (Mrp) 3, Mrp4, and breast cancer resistance protein, as well as increased Mrp2 protein.
Positive_regulation (increases) of multidrug resistance-associated protein in livers associated with breast cancer
19) Confidence 0.03 Published 2007 Journal Drug Metab. Dispos. Section Abstract Doc Link 17640958 Disease Relevance 0.93 Pain Relevance 0.99

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