INT78935

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Context Info
Confidence 0.48
First Reported 1998
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 1.25
Pain Relevance 0.97

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Cacna1c) plasma membrane (Cacna1c) nucleus (Cacna1c)
transmembrane transport (Cacna1c) cytoplasm (Cacna1c)
Anatomy Link Frequency
nerve 1
Cacna1c (Mus musculus)
Pain Link Frequency Relevance Heat
Calcium channel 3 100.00 Very High Very High Very High
antagonist 14 99.40 Very High Very High Very High
Onset of action 1 89.84 High High
headache 1 83.72 Quite High
agonist 1 83.12 Quite High
Central nervous system 1 76.88 Quite High
Pain 1 69.76 Quite High
Morphine 1 69.28 Quite High
tolerance 1 68.56 Quite High
addiction 1 67.44 Quite High
Disease Link Frequency Relevance Heat
Bone Cancer 8 99.96 Very High Very High Very High
Heart Rate Under Development 3 88.56 High High
Cancer 5 86.72 High High
Headache 1 83.72 Quite High
Multiple Myeloma 2 79.64 Quite High
Pain 1 69.76 Quite High
Natriuresis 1 65.08 Quite High
Hypertrophy 1 63.64 Quite High
Metastasis 1 59.40 Quite High
Breast Cancer 1 51.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results demonstrate that MBC-11 decreases bone tumor burden, maintains bone structure, and may increase overall survival, warranting further investigation as a treatment for TIBD.
Localization (decreases) of MBC-11 associated with bone cancer
1) Confidence 0.48 Published 2010 Journal Bone Section Abstract Doc Link 20233612 Disease Relevance 0.79 Pain Relevance 0
The CA thus concentrated are slowly released from these depots and, subsequently, reach their targets, the L-type calcium channels.
Localization (released) of L-type associated with calcium channel and antagonist
2) Confidence 0.42 Published 1998 Journal Blood Press Suppl Section Abstract Doc Link 9850436 Disease Relevance 0.38 Pain Relevance 0.56
The L-type calcium channel is localized on nerve terminals in the pre- and postsynaptic parts, as well as on cell bodies and may be involved in the mechanism of action of psychotropic drugs.
Localization (localized) of L-type in nerve associated with calcium channel
3) Confidence 0.18 Published 1999 Journal Pol J Pharmacol Section Abstract Doc Link 10425648 Disease Relevance 0.07 Pain Relevance 0.42

General Comments

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