INT78938

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Context Info
Confidence 0.45
First Reported 1998
Last Reported 2010
Negated 5
Speculated 0
Reported most in Body
Documents 40
Total Number 40
Disease Relevance 27.95
Pain Relevance 1.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IGFBP3) extracellular region (IGFBP3) nucleus (IGFBP3)
Anatomy Link Frequency
plasma 10
muscle 1
osteoblast 1
nucleus 1
molar 1
IGFBP3 (Homo sapiens)
IGFBP3 - A8618T (1)
Pain Link Frequency Relevance Heat
Fibrositis 2 99.76 Very High Very High Very High
Pain 13 98.98 Very High Very High Very High
Bioavailability 56 98.32 Very High Very High Very High
alcohol 36 95.28 Very High Very High Very High
spinal inflammation 4 91.56 High High
metalloproteinase 4 87.68 High High
nMDA receptor 8 86.88 High High
Osteoarthritis 7 78.00 Quite High
headache 15 72.08 Quite High
tolerance 8 71.08 Quite High
Disease Link Frequency Relevance Heat
Apoptosis 872 100.00 Very High Very High Very High
Targeted Disruption 345 100.00 Very High Very High Very High
Adenoma 601 99.80 Very High Very High Very High
Fibromyalgia 2 99.76 Very High Very High Very High
Cancer 244 99.48 Very High Very High Very High
Sprains And Strains 43 99.32 Very High Very High Very High
Osteoporosis 16 99.18 Very High Very High Very High
Sleep Disorders 559 98.56 Very High Very High Very High
Chronic Renal Failure 85 97.68 Very High Very High Very High
Aging 18 97.24 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Genetic, anthropometric, and lifestyle factors associated with IGF-1 and IGFBP-3 levels in Hispanic and non-Hispanic white women.
IGFBP-3 Binding (associated) of
1) Confidence 0.45 Published 2005 Journal Cancer Causes Control Section Title Doc Link 16215864 Disease Relevance 0.33 Pain Relevance 0
There was no association between plasma IGFBP-3 and adenoma risk or apoptosis.
plasma IGFBP-3 Neg (no) Binding (association) of in plasma associated with adenoma and apoptosis
2) Confidence 0.42 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2409350 Disease Relevance 1.76 Pain Relevance 0
Surprisingly, the association of tissue IGFBP-3 and apoptosis was not as expected.
tissue IGFBP-3 Binding (association) of associated with apoptosis
3) Confidence 0.42 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2409350 Disease Relevance 1.94 Pain Relevance 0
The normalized ratio for IGFBP3 abundance was calculated as the ratio of IGFBP-3/PBGD for each sample divided by the IGFBP-3/PBGD ratio of the calibrator.
IGFBP-3 Binding (ratio) of
4) Confidence 0.37 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2409350 Disease Relevance 0 Pain Relevance 0
The interactions of IGFBP-3 with other factors coupled with the complex nature of the IGF-axis may explain our findings.
IGFBP-3 Binding (interactions) of
5) Confidence 0.37 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2409350 Disease Relevance 0.96 Pain Relevance 0
The CC genotype of the -202 A>C polymorphism of the IGFBP3 gene was associated with lower IGFBP-3 levels in both ethnic groups.
IGFBP3 Binding (associated) of
6) Confidence 0.35 Published 2005 Journal Cancer Causes Control Section Abstract Doc Link 16215864 Disease Relevance 0.49 Pain Relevance 0.09
IGF-1 and IGFBP-3 both promote the differentiation of bone, with systemic levels of IGF-1 and IGFBP-3 positively associated with bone mass density [12].
IGFBP-3 Binding (associated) of
7) Confidence 0.33 Published 2003 Journal Tob Induc Dis Section Body Doc Link PMC2669552 Disease Relevance 0.57 Pain Relevance 0.03
IGF-1 and IGFBP-3 both promote the differentiation of bone, with systemic levels of IGF-1 and IGFBP-3 positively associated with bone mass density [12].
IGFBP-3 Binding (associated) of
8) Confidence 0.33 Published 2003 Journal Tob Induc Dis Section Body Doc Link PMC2671651 Disease Relevance 0.57 Pain Relevance 0.03
The differential association of tissue IGFBP-3 versus plasma IGFBP-3 with adenoma risk suggests that local IGFBP-3 may better correlate with the functional effects in colonic tissue compared with systemic levels.
plasma IGFBP-3 Binding (association) of in plasma associated with adenoma
9) Confidence 0.33 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2409350 Disease Relevance 1.39 Pain Relevance 0.04
The differential association of tissue IGFBP-3 versus plasma IGFBP-3 with adenoma risk suggests that local IGFBP-3 may better correlate with the functional effects in colonic tissue compared with systemic levels.
tissue IGFBP-3 Binding (association) of in plasma associated with adenoma
10) Confidence 0.33 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2409350 Disease Relevance 1.38 Pain Relevance 0.03
Table 2 shows the unadjusted and adjusted odds ratios (OR) for the associations of plasma IGFBP-3, tissue IGFBP-3 and adenomas.
plasma IGFBP-3 Binding (associations) of in plasma associated with adenoma
11) Confidence 0.33 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2409350 Disease Relevance 0.98 Pain Relevance 0.08
Table 2 shows the unadjusted and adjusted odds ratios (OR) for the associations of plasma IGFBP-3, tissue IGFBP-3 and adenomas.
tissue IGFBP-3 Binding (associations) of in plasma associated with adenoma
12) Confidence 0.33 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2409350 Disease Relevance 1.03 Pain Relevance 0.08
Several studies suggest an inverse association between plasma IGFBP-3 and risk of cancer in a number of organs [1,3,20,46,47].
plasma IGFBP-3 Binding (association) of in plasma associated with cancer
13) Confidence 0.31 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2409350 Disease Relevance 1.24 Pain Relevance 0
Similar procedures were used for analysis of associations between apoptosis and plasma or tissue IGFBP-3, except apoptosis was the response instead of adenoma status and IGFBP-3 variable divided into quartiles was the predictor.


tissue IGFBP-3 Neg (except) Binding (associations) of in plasma associated with adenoma and apoptosis
14) Confidence 0.31 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2409350 Disease Relevance 1.26 Pain Relevance 0.14
We observed no significant association between plasma IGFBP-3 and apoptosis.
plasma IGFBP-3 Neg (no) Binding (association) of in plasma associated with apoptosis
15) Confidence 0.31 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2409350 Disease Relevance 1.68 Pain Relevance 0.03
There was no significant association between plasma IGFBP-3 and adenomas or apoptosis.
plasma IGFBP-3 Neg (no) Binding (association) of in plasma associated with adenoma and apoptosis
16) Confidence 0.31 Published 2008 Journal BMC Cancer Section Abstract Doc Link PMC2409350 Disease Relevance 1.21 Pain Relevance 0.03
As IGFBP3 is known to have modulatory effects on transcription, for example through its binding to nur 77 [21], a possible explanation for IGFBP3 effects on sleep could be transcriptional modulation of the preprohypocretin gene.
IGFBP3 Binding (binding) of
17) Confidence 0.30 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2617764 Disease Relevance 0.48 Pain Relevance 0
The insulin-like growth factor binding protein-3 (IGFBP-3) is the main carrier protein binding to IGF-I in plasma, thus determining its bioavailability.
IGFBP-3 Binding (binding) of in plasma associated with bioavailability
18) Confidence 0.27 Published 2010 Journal Thyroid Res Section Body Doc Link PMC2858102 Disease Relevance 0.09 Pain Relevance 0.05
The concentration of IGFBP3, the main IGF carrier protein, is usually increased in patients with acromegaly, but this marker offers little further diagnostic information.


IGFBP3 Binding (concentration) of associated with acromegaly
19) Confidence 0.25 Published 2008 Journal Orphanet J Rare Dis Section Body Doc Link PMC2459162 Disease Relevance 0.60 Pain Relevance 0.04
IGFBP3 is also reported to have proapoptotic properties independent of IGF-binding.
IGFBP3 Binding (binding) of
20) Confidence 0.23 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2617764 Disease Relevance 0.80 Pain Relevance 0

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