INT7894

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Context Info
Confidence 0.59
First Reported 1980
Last Reported 2010
Negated 2
Speculated 2
Reported most in Abstract
Documents 59
Total Number 61
Disease Relevance 11.76
Pain Relevance 27.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Vip)
Anatomy Link Frequency
smooth muscle 3
nerve 3
gut 2
parotid glands 2
ileum 1
Vip (Rattus norvegicus)
Pain Link Frequency Relevance Heat
substance P 116 100.00 Very High Very High Very High
antagonist 101 100.00 Very High Very High Very High
Neuropeptide 75 100.00 Very High Very High Very High
Enkephalin 74 100.00 Very High Very High Very High
Somatostatin 67 100.00 Very High Very High Very High
Calcitonin gene-related peptide 55 100.00 Very High Very High Very High
gABA 49 100.00 Very High Very High Very High
qutenza 34 100.00 Very High Very High Very High
Cholecystokinin 24 100.00 Very High Very High Very High
Dynorphin 14 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Parkinson's Disease 4 99.84 Very High Very High Very High
Aging 3 99.76 Very High Very High Very High
Diabetes Mellitus 12 99.70 Very High Very High Very High
Increased Venous Pressure Under Development 40 99.60 Very High Very High Very High
Obesity 20 99.52 Very High Very High Very High
Vibrio Infection 2 99.52 Very High Very High Very High
Diarrhoea 4 99.10 Very High Very High Very High
Pain 18 99.04 Very High Very High Very High
Hyperalgesia 3 98.72 Very High Very High Very High
Pulmonary Hypertension 212 97.96 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, antagonists that inhibit VIP activity may prove beneficial in the alleviation of OA pain.
Negative_regulation (inhibit) of VIP associated with pain, antagonist and osteoarthritis
1) Confidence 0.59 Published 2006 Journal Pain Section Abstract Doc Link 16564620 Disease Relevance 1.28 Pain Relevance 1.20
Untreated diabetes significantly reduced tissue concentrations of vasoactive intestinal polypeptide (VIP) at both intestinal loci.
Negative_regulation (reduced) of VIP associated with diabetes mellitus
2) Confidence 0.58 Published 1995 Journal Dig. Dis. Sci. Section Abstract Doc Link 7720477 Disease Relevance 0.57 Pain Relevance 0.05
CONCLUSIONS: These data suggest that the decrease in CGRP and VIP content in the airway tissues may be one of the consequences, but not the cause, of impaired gas exchange by endotracheal intubation.
Negative_regulation (decrease) of VIP
3) Confidence 0.57 Published 1998 Journal Eur. J. Clin. Invest. Section Body Doc Link 9568472 Disease Relevance 0 Pain Relevance 0
We also studied if inhibition of VIP enzymatic cleavage using a combination of an inhibitor of neutral endopeptidase [thiorphan (Thio)] and an inhibitor of serine proteases [soybean trypsin inhibitor (STI)] influenced the airway effects of capsaicin.
Negative_regulation (inhibition) of VIP in cleavage associated with qutenza
4) Confidence 0.46 Published 1996 Journal Am. J. Physiol. Section Abstract Doc Link 8897896 Disease Relevance 0 Pain Relevance 0.40
CONCLUSION: Eye-acupuncture can reduce serum and coIonic SP and VIP contents in IBS rats, which may play a role in relieving IBS in eye-acupuncture clinic.


Negative_regulation (reduce) of VIP in Eye
5) Confidence 0.43 Published 2010 Journal Zhen Ci Yan Jiu Section Body Doc Link 20458899 Disease Relevance 0.05 Pain Relevance 0
The effects of VIP and PACAPs were completely antagonized by nitric oxide (NO) synthase inhibitor NG-nitro-L-arginine (L-NA), suggesting that NO mediates the inhibitory effects of VIP and PACAPs on duodenal motility.
Negative_regulation (effects) of VIP
6) Confidence 0.43 Published 1999 Journal Neurogastroenterol. Motil. Section Abstract Doc Link 10354348 Disease Relevance 0 Pain Relevance 0.27
The inhibitory effect of beta-endorphin and VIP was blocked by naloxone.
Negative_regulation (blocked) of VIP associated with narcan
7) Confidence 0.43 Published 1983 Journal Jpn. J. Physiol. Section Abstract Doc Link 6199539 Disease Relevance 0 Pain Relevance 0.15
It was concluded that VIP was the neurotransmitter responsible for the dominant inhibitory neural input to intestinal circular muscle and that opioid peptides induce phasic contractions by suppressing VIP release.
Negative_regulation (suppressing) of VIP in muscle associated with neurotransmitter and opioid
8) Confidence 0.43 Published 1987 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 3668852 Disease Relevance 0 Pain Relevance 0.84
The inhibition by VIP of pyruvate dehydrogenase and acetylcoenzyme-A carboxylase, the enzymes considered as the target sites for the neuropeptide, was also abolished by epinephrine.
Negative_regulation (inhibition) of VIP associated with neuropeptide
9) Confidence 0.42 Published 1989 Journal Endocrinology Section Abstract Doc Link 2470585 Disease Relevance 0 Pain Relevance 0.19
A marked, extensive depletion of VIP, NPY- and SP-immunoreactive nerves was observed after distension.
Negative_regulation (depletion) of VIP in nerves associated with substance p
10) Confidence 0.42 Published 1992 Journal Urol. Res. Section Abstract Doc Link 1380745 Disease Relevance 0.23 Pain Relevance 0.42
Capsaicin treatment induced a loss of VIP/PHI from the dorsal horn.
Negative_regulation (loss) of VIP in dorsal horn associated with qutenza and dorsal horn
11) Confidence 0.42 Published 1986 Journal Peptides Section Abstract Doc Link 3529051 Disease Relevance 0 Pain Relevance 0.35
Tetraethylammonium (TEA) reduced VIP- but not PACAP-27-induced relaxations, while charybdotoxin was ineffective.
Negative_regulation (reduced) of VIP
12) Confidence 0.42 Published 1999 Journal Regul. Pept. Section Abstract Doc Link 10651061 Disease Relevance 0 Pain Relevance 0.09
The changes in the VIP receptor 24 hours after castration were prevented by prior injection of testosterone.
Negative_regulation (prevented) of VIP receptor
13) Confidence 0.42 Published 1990 Journal Peptides Section Abstract Doc Link 1965030 Disease Relevance 0 Pain Relevance 0.14
Pelvic nerve section induced a decrease of VIP/PHI immunoreactivity from the spinal cord and no change or a minimal increase in immunoreactive nerve fibers of the bladder.
Negative_regulation (decrease) of VIP in spinal cord associated with spinal cord
14) Confidence 0.41 Published 1986 Journal Peptides Section Abstract Doc Link 3529051 Disease Relevance 0 Pain Relevance 0.36
Previous studies in peristaltic preparations have also shown that an increase in somatostatin release during the descending phase causes a decrease in Met-enkephalin release and suppression of the inhibitory effect of Met-enkephalin on VIP/PACAP/NOS motor neurons innervating circular muscle and a distinct set of VIP/PACAP/NOS interneurons.
Negative_regulation (effect) of VIP in motor neurons associated with somatostatin and enkephalin
15) Confidence 0.41 Published 2003 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 12684209 Disease Relevance 0 Pain Relevance 0.50
Local denervation immediately proximal to the sphincter markedly reduced the numbers of VIP/NOS/galanin- and VIP/NOS/galanin/PACAP +/- NPY-containing fibres within the sphincter suggesting an origin of these fibres in myenteric ganglia in the antral region; denervation at the level of the oxyntic-pyloric border had no effect.
Negative_regulation (numbers) of VIP in ganglia
16) Confidence 0.39 Published 2002 Journal Auton Neurosci Section Abstract Doc Link 12132647 Disease Relevance 0 Pain Relevance 0.94
Extrinsic denervation caused a total loss of NPY/TH-, SP/CGRP- and SP/CGRP/VIP/NOS/PACAP-containing nerve fibres.
Negative_regulation (loss) of VIP in nerve associated with calcitonin gene-related peptide and substance p
17) Confidence 0.39 Published 2002 Journal Auton Neurosci Section Abstract Doc Link 12132647 Disease Relevance 0 Pain Relevance 0.89
Tetrodotoxin, hexamethonium and methionine enkephalin inhibited both the induced VIP release and the secretory response.
Negative_regulation (inhibited) of VIP associated with tetrodotoxin and enkephalin
18) Confidence 0.38 Published 1990 Journal Acta Physiol. Scand. Section Abstract Doc Link 1972607 Disease Relevance 0.15 Pain Relevance 0.32
The patient underwent a treatment with SMS 201-995 with improvement of symptomatology and reduction of circulating VIP levels.
Negative_regulation (reduction) of VIP
19) Confidence 0.38 Published 1993 Journal J. Endocrinol. Invest. Section Abstract Doc Link 8383153 Disease Relevance 0.61 Pain Relevance 0.13
The VIP effect was not inhibited by a mixture of tetrodotoxin, atropine, I-propranolol, and phentolamine.
Negative_regulation (inhibited) of VIP associated with tetrodotoxin
20) Confidence 0.38 Published 1983 Journal Am. Rev. Respir. Dis. Section Abstract Doc Link 6870072 Disease Relevance 0 Pain Relevance 0.10

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