INT78942

Context Info Confidence 0.57 First Reported 1998 Last Reported 2005 Negated 0 Speculated 1 Reported most in Body Documents 1 Total Number 2 Disease Relevance 1.79 Pain Relevance 0.08

nucleolus (DDX41) RNA binding (DDX41) nucleus (DDX41) helicase activity (DDX41)

DDX41 (Homo sapiens)

Pain Link Frequency Relevance Heat idiopathic sensory neuropathy 1 78.52 depression 6 5.00 withdrawal 5 5.00 Pain 3 5.00

Disease Link Frequency Relevance Heat Neuropathic Pain 8 99.88 Cancer 2 99.28 Small Cell Lung Cancer 3 98.78 Small Cell Lung Carcinoma 1 90.88 Aggression 156 82.68 Dementia 10 59.04 Cognitive Disorder 40 5.00 Stress 8 5.00 Depression 6 5.00 Sleep Disorders 4 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

This study confirms the value of Hu-Abs for the diagnosis of PSN and SCLC and also emphasizes that in patients with possible PSN, the absence of Hu-Abs does not exclude cancer, particularly in those patients with risk factors for SCLC.

Spec (possible) Negative_regulation (absence) of Abs associated with cancer, neuropathic pain and small cell lung cancer

1) Confidence 0.57 Published 1998 Journal Ann. Neurol. Section Abstract Doc Link 9851446 Disease Relevance 1.24 Pain Relevance 0.08

Although there is a relatively high prevalence of ABs (21%), the majority are not displayed often.

Negative_regulation (prevalence) of ABs

2) Confidence 0.27 Published 2005 Journal BMC Geriatr Section Body Doc Link PMC1310539 Disease Relevance 0.55 Pain Relevance 0

General Comments

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