INT78955

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Context Info
Confidence 0.62
First Reported 1998
Last Reported 2008
Negated 1
Speculated 4
Reported most in Abstract
Documents 12
Total Number 16
Disease Relevance 7.22
Pain Relevance 6.02

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Ptgs2) nuclear envelope (Ptgs2) oxidoreductase activity (Ptgs2)
endoplasmic reticulum (Ptgs2) nucleus (Ptgs2) enzyme binding (Ptgs2)
Anatomy Link Frequency
spinal cord 8
biliary tract 4
spinal 2
tibia 2
skin 1
Ptgs2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Pain 26 100.00 Very High Very High Very High
COX2 13 100.00 Very High Very High Very High
qutenza 6 100.00 Very High Very High Very High
Spinal cord 32 99.84 Very High Very High Very High
Inflammatory response 2 99.80 Very High Very High Very High
cINOD 23 99.76 Very High Very High Very High
IPN 2 99.52 Very High Very High Very High
Prostatitis 4 99.40 Very High Very High Very High
antinociception 2 99.08 Very High Very High Very High
Inflammation 19 98.40 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pain 17 100.00 Very High Very High Very High
Disease 8 99.96 Very High Very High Very High
INFLAMMATION 29 99.80 Very High Very High Very High
Inflammatory Pain 2 99.52 Very High Very High Very High
Reprotox - General 1 4 99.40 Very High Very High Very High
Malignant Neoplastic Disease 4 98.76 Very High Very High Very High
Pressure And Volume Under Development 4 98.58 Very High Very High Very High
Cancer 11 97.44 Very High Very High Very High
Nociception 4 97.16 Very High Very High Very High
Neuropathic Pain 13 94.68 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We investigated the effect of intraprostatic botulinum toxin A administration on pain reaction and cyclooxygenase-2 expression in a capsaicin induced prostatitis model in rats.
Spec (investigated) Regulation (effect) of Gene_expression (expression) of cyclooxygenase-2 associated with pain, qutenza and prostatitis
1) Confidence 0.62 Published 2008 Journal J. Urol. Section Abstract Doc Link 18554636 Disease Relevance 0.55 Pain Relevance 0.59
In the present study, we examined the changes of cyclooxygenase-1 and cyclooxygenase-2 protein expression in several regions of the CNS associated with pain perception, and the role of spinal cyclooxygenase activity in the development of allodynia following nerve injury.
Spec (examined) Regulation (changes) of Gene_expression (expression) of cyclooxygenase-2 in spinal associated with pain, nervous system injury and allodynia
2) Confidence 0.60 Published 2000 Journal Neuroscience Section Abstract Doc Link 10842019 Disease Relevance 0.72 Pain Relevance 0.54
Effect of endotoxin treatment on the expression of cyclooxygenase-2 and prostaglandin synthases in spinal cord, dorsal root ganglia, and skin of rats.
Regulation (Effect) of Gene_expression (expression) of cyclooxygenase-2 in spinal cord associated with cox2 and spinal cord
3) Confidence 0.55 Published 2003 Journal Neuroscience Section Title Doc Link 12617945 Disease Relevance 0.10 Pain Relevance 0.29
The prostate and L6 spinal cord were then removed for histology and cyclooxygenase-2 expression using Western blotting or immunostaining.
Regulation (removed) of Gene_expression (expression) of cyclooxygenase-2 in spinal cord
4) Confidence 0.45 Published 2008 Journal J. Urol. Section Body Doc Link 18554636 Disease Relevance 0.17 Pain Relevance 0
Dihydrocucurbitacin B modified the evolution of the clinical symptoms, reducing the swelling and bone and tissue damage along with the development of the disease, modifying the cell infiltration and the expression of both nitric oxide synthase-2 and cyclooxygenase-2.
Regulation (modifying) of Gene_expression (expression) of cyclooxygenase-2 associated with pressure and volume under development and disease
5) Confidence 0.45 Published 2006 Journal Eur. J. Pharmacol. Section Abstract Doc Link 16443215 Disease Relevance 0.94 Pain Relevance 0.19
Taken together, such results suggest that low-level laser therapy is able to improve bone repair in the tibia of rats as a result of an up-regulation for cyclooxygenase-2 expression in bone cells.
Regulation (regulation) of Gene_expression (expression) of cyclooxygenase-2 in tibia
6) Confidence 0.33 Published 2008 Journal J Oral Rehabil Section Abstract Doc Link 19090909 Disease Relevance 0.24 Pain Relevance 0.18
After abdominal irradiation of all of the animals except the six in the control group, the expression of the enzyme cyclooxygenase-2 (COX-2) was evaluated in different cell types present in the intestinal wall 2 h post exposure (study day 0) and again on study days 4, 14, and 60.
Regulation (evaluated) of Gene_expression (expression) of cyclooxygenase-2
7) Confidence 0.28 Published 2006 Journal J. Surg. Res. Section Body Doc Link 16780881 Disease Relevance 0.09 Pain Relevance 0
The effect of [3,4-di(4-methoxyphenyl)-5-isoxazolyl] acetic acid (mofezolac), a potent and highly preferential inhibitor of cyclooxygenase-1, and N-[2-(cyclohexyloxy)-4-nitrophenyl]methanesulphonamide (NS-398), a selective inhibitor of cyclooxygenase-2, on DNA fragmentation and cyclooxygenase-2 mRNA expression was weak compared to the effect of indomethacin or sodium diclofenac.
Regulation (effect) of Gene_expression (expression) of cyclooxygenase-2 associated with diclofenac
8) Confidence 0.28 Published 1998 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9851595 Disease Relevance 0.49 Pain Relevance 0.72
We have examined the role of peripheral prostaglandins synthesized by cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) in inflammatory pain using the PIFIR model.
Spec (examined) Regulation (role) of Gene_expression (synthesized) of cyclooxygenase-2 associated with ipn
9) Confidence 0.20 Published 2002 Journal J. Pharm. Pharmacol. Section Abstract Doc Link 11902807 Disease Relevance 0.70 Pain Relevance 0.78
Effect of endotoxin treatment on the expression of cyclooxygenase-2 and prostaglandin synthases in spinal cord, dorsal root ganglia, and skin of rats.
Regulation (Effect) of in dorsal root ganglia Gene_expression (expression) of cyclooxygenase-2 in spinal cord associated with cox2 and spinal cord
10) Confidence 0.19 Published 2003 Journal Neuroscience Section Title Doc Link 12617945 Disease Relevance 0.10 Pain Relevance 0.29
Effect of endotoxin treatment on the expression of cyclooxygenase-2 and prostaglandin synthases in spinal cord, dorsal root ganglia, and skin of rats.
Regulation (Effect) of in skin Gene_expression (expression) of cyclooxygenase-2 in spinal cord associated with cox2 and spinal cord
11) Confidence 0.19 Published 2003 Journal Neuroscience Section Title Doc Link 12617945 Disease Relevance 0.10 Pain Relevance 0.29
Since variants in the PTGS2 gene may modify the expression or function of its encoded enzyme to modulate the inflammatory response in the biliary tract, we examined the associations of eight PTGS2 polymorphisms (-645C-->T; Ex3 -8G-->C; IVS5 -275T-->G; IVS7 +111T-->C; Ex10 +127T-->C; Ex10 +686 --->ATTAT-->TTATA; Ex10 +837T-->C; Ex10 -90C-->T) with biliary tract cancer and stones in a population-based case-control study conducted in Shanghai, China.
Regulation (modulate) of Gene_expression (expression) of PTGS2 in biliary tract associated with inflammatory response and biliary cancer
12) Confidence 0.17 Published 2006 Journal Carcinogenesis Section Abstract Doc Link 16361272 Disease Relevance 0.85 Pain Relevance 0.50
Since variants in the PTGS2 gene may modify the expression or function of its encoded enzyme to modulate the inflammatory response in the biliary tract, we examined the associations of eight PTGS2 polymorphisms (-645C-->T; Ex3 -8G-->C; IVS5 -275T-->G; IVS7 +111T-->C; Ex10 +127T-->C; Ex10 +686 --->ATTAT-->TTATA; Ex10 +837T-->C; Ex10 -90C-->T) with biliary tract cancer and stones in a population-based case-control study conducted in Shanghai, China.
Spec (may) Regulation (modify) of Gene_expression (expression) of PTGS2 in biliary tract associated with inflammatory response and biliary cancer
13) Confidence 0.17 Published 2006 Journal Carcinogenesis Section Abstract Doc Link 16361272 Disease Relevance 0.84 Pain Relevance 0.50
The authors also found up-regulation of cyclooxygenase-2 expression and phosphorylation of protein kinase Akt at Ser-473 in response to opioid withdrawal.
Regulation (regulation) of Gene_expression (expression) of cyclooxygenase-2
14) Confidence 0.15 Published 2006 Journal Anesthesiology Section Body Doc Link 16810007 Disease Relevance 0 Pain Relevance 0
In contrast, no significant effects of minocycline were observed on gp120-induced IL-6 and cyclooxygenase-2 expression in spinal cord or CSF IL-6 levels.
Neg (no) Regulation (effects) of Gene_expression (expression) of cyclooxygenase-2 in spinal cord associated with spinal cord
15) Confidence 0.13 Published 2005 Journal Pain Section Abstract Doc Link 15836971 Disease Relevance 1.07 Pain Relevance 1.05
is obviously associated with the isatin effect on expression of inducible nitric oxide synthase and cyclooxygenase-2 respectively, as it has been demonstrated by a Western blot analysis (Matheus et al 2007).
Regulation (effect) of Gene_expression (expression) of cyclooxygenase-2
16) Confidence 0.05 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721300 Disease Relevance 0.26 Pain Relevance 0.11

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