INT78956

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Context Info
Confidence 0.35
First Reported 1998
Last Reported 2008
Negated 0
Speculated 1
Reported most in Abstract
Documents 3
Total Number 4
Disease Relevance 1.42
Pain Relevance 1.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nuclear envelope (Ptgs1) aging (Ptgs1) Golgi apparatus (Ptgs1)
endoplasmic reticulum (Ptgs1) cytoplasm (Ptgs1) lipid binding (Ptgs1)
Anatomy Link Frequency
neurons 2
renal medulla 2
lung 2
Ptgs1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
ketamine 1 100.00 Very High Very High Very High
anesthesia 1 100.00 Very High Very High Very High
cINOD 9 99.84 Very High Very High Very High
qutenza 9 99.84 Very High Very High Very High
medulla 5 99.28 Very High Very High Very High
antagonist 1 97.90 Very High Very High Very High
Analgesic 1 94.16 High High
Bile 2 89.76 High High
diclofenac 4 86.60 High High
COX2 2 25.00 Low Low
Disease Link Frequency Relevance Heat
Injury 3 99.82 Very High Very High Very High
Hypertension 3 99.00 Very High Very High Very High
INFLAMMATION 3 96.96 Very High Very High Very High
Cirrhosis 8 92.16 High High
Pressure And Volume Under Development 1 84.04 Quite High
Apoptosis 5 76.04 Quite High
Colon Cancer 1 74.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The aim of the present study was to investigate a possible interaction between ketoprofen and caffeine on prostaglandin (PG) biosynthesis and cyclooxygenase (COX) mRNA expression in the rat renal medulla ex vivo.
Spec (possible) Regulation (interaction) of Transcription (expression) of cyclooxygenase in renal medulla associated with medulla
1) Confidence 0.35 Published 2001 Journal Pharmacology Section Abstract Doc Link 11729362 Disease Relevance 0.10 Pain Relevance 0.42
In contrast, the expression of mRNA for cyclooxygenase-1 was constitutive and was never affected by NSAIDs.
Regulation (affected) of Transcription (expression) of cyclooxygenase-1 associated with cinod
2) Confidence 0.23 Published 1998 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9851595 Disease Relevance 0.44 Pain Relevance 0.60
OBJECTIVE AND DESIGN: The purpose of the present study was to evaluate the effect of urethane, pentobarbital sodium and ketamine-xylazine anesthesia upon constitutive and inducible cyclooxygenase (COX-1; COX-2) and nitric oxide synthase (eNOS; iNOS) mRNA levels in the lung.
Regulation (effect) of Transcription (levels) of cyclooxygenase in lung associated with anesthesia and ketamine
3) Confidence 0.17 Published 2000 Journal Inflamm. Res. Section Abstract Doc Link 11211925 Disease Relevance 0 Pain Relevance 0.15
The aim of this study was to examine the impact of ablation of capsaicin-sensitive neurons and the tachykinin NK(1) receptor antagonist A5330 on the susceptibility of the portal hypertensive gastric mucosa to ethanol-induced injury and its effects on gastric cyclooxygenase (COX) and nitric oxide synthase (NOS) mRNA expression.
Regulation (effects) of Transcription (expression) of gastric cyclooxygenase in neurons associated with qutenza, antagonist, injury and hypertension
4) Confidence 0.07 Published 2008 Journal Eur. J. Pharmacol. Section Abstract Doc Link 18555214 Disease Relevance 0.89 Pain Relevance 0.53

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