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Context Info
Confidence 0.17
First Reported 1998
Last Reported 1998
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.49
Pain Relevance 0.72

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lipid binding (Ptgs2) nuclear envelope (Ptgs2) oxidoreductase activity (Ptgs2)
endoplasmic reticulum (Ptgs2) nucleus (Ptgs2) enzyme binding (Ptgs2)
Ptgs2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cINOD 7 99.76 Very High Very High Very High
diclofenac 4 97.64 Very High Very High Very High
COX2 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Apoptosis 5 75.00 Quite High
INFLAMMATION 2 75.00 Quite High
Colon Cancer 1 70.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The effect of [3,4-di(4-methoxyphenyl)-5-isoxazolyl] acetic acid (mofezolac), a potent and highly preferential inhibitor of cyclooxygenase-1, and N-[2-(cyclohexyloxy)-4-nitrophenyl]methanesulphonamide (NS-398), a selective inhibitor of cyclooxygenase-2, on DNA fragmentation and cyclooxygenase-2 mRNA expression was weak compared to the effect of indomethacin or sodium diclofenac.
Regulation (effect) of Transcription (expression) of cyclooxygenase-2 associated with diclofenac
1) Confidence 0.17 Published 1998 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9851595 Disease Relevance 0.49 Pain Relevance 0.72

General Comments

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