INT78958

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Context Info
Confidence 0.42
First Reported 1998
Last Reported 2009
Negated 1
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 2.61
Pain Relevance 2.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Ptgs2) nuclear envelope (Ptgs2) oxidoreductase activity (Ptgs2)
endoplasmic reticulum (Ptgs2) nucleus (Ptgs2) enzyme binding (Ptgs2)
Anatomy Link Frequency
bowel 2
Ptgs2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
COX2 12 100.00 Very High Very High Very High
Inflammation 9 100.00 Very High Very High Very High
cINOD 11 99.76 Very High Very High Very High
cytokine 4 99.74 Very High Very High Very High
cOX1 1 99.74 Very High Very High Very High
diclofenac 4 95.28 Very High Very High Very High
COX-2 inhibitor 2 90.32 High High
acular 5 77.92 Quite High
Pain 1 74.84 Quite High
anesthesia 1 25.00 Low Low
Disease Link Frequency Relevance Heat
INFLAMMATION 13 100.00 Very High Very High Very High
Fracture Healing 3 99.84 Very High Very High Very High
Cardiovascular Disease 4 99.40 Very High Very High Very High
Enteropathy 1 96.28 Very High Very High Very High
Necrosis 2 91.16 High High
Cancer 2 90.80 High High
Apoptosis 5 75.00 Quite High
Hypertension 3 71.24 Quite High
Stroke 1 70.72 Quite High
Colon Cancer 1 70.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Effects of a cyclooxygenase 2 inhibitor on fracture healing in a rat model.
Regulation (Effects) of Negative_regulation (inhibitor) of cyclooxygenase 2 associated with fracture healing and cox2
1) Confidence 0.42 Published 2008 Journal Am J. Orthop. Section Title Doc Link 18795192 Disease Relevance 0.28 Pain Relevance 0.22
In J774 cells, the inhibition of 6-keto-PGF(1alpha) and NO(2)(-) production by roxithromycin and erythromycin was not dependent on direct inhibition of cyclooxygenase-2 and inducible nitric oxide synthase activity because it appears to be related to the inhibition of cyclooxygenase-2 and inducible nitric oxide synthase protein expression.
Neg (not) Regulation (dependent) of Negative_regulation (inhibition) of cyclooxygenase-2
2) Confidence 0.36 Published 2000 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 10604943 Disease Relevance 0.72 Pain Relevance 0.23
We evaluated the effects of cyclooxygenase-2 (COX-2) selective inhibitors, COX-1 selective inhibitor, or COX non-selective inhibitor on gastric emptying and intestinal transit of liquids, and evaluated the effect of a COX-2 selective inhibitor on gastric tonus (GT).
Regulation (effects) of Negative_regulation (inhibitors) of cyclooxygenase-2
3) Confidence 0.35 Published 2007 Journal Neurogastroenterol. Motil. Section Abstract Doc Link 17300293 Disease Relevance 0 Pain Relevance 0.23
Effect of a selective nonsteroidal anti-inflammatory inhibitor of cyclooxygenase-2 on the small bowel of rats.
Regulation (Effect) of Negative_regulation (inhibitor) of cyclooxygenase-2 in bowel associated with inflammation and cox2
4) Confidence 0.31 Published 2004 Journal Braz. J. Med. Biol. Res. Section Title Doc Link 15060699 Disease Relevance 0.29 Pain Relevance 0.37
The effect of [3,4-di(4-methoxyphenyl)-5-isoxazolyl] acetic acid (mofezolac), a potent and highly preferential inhibitor of cyclooxygenase-1, and N-[2-(cyclohexyloxy)-4-nitrophenyl]methanesulphonamide (NS-398), a selective inhibitor of cyclooxygenase-2, on DNA fragmentation and cyclooxygenase-2 mRNA expression was weak compared to the effect of indomethacin or sodium diclofenac.
Regulation (effect) of Negative_regulation (inhibitor) of cyclooxygenase-2 associated with diclofenac
5) Confidence 0.28 Published 1998 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9851595 Disease Relevance 0.49 Pain Relevance 0.71
Differential effects of p38 mitogen-activated protein kinase and cyclooxygenase 2 inhibitors in a model of cardiovascular disease.
Regulation (effects) of Negative_regulation (inhibitors) of cyclooxygenase 2 associated with cardiovascular disease, cox2 and cox1
6) Confidence 0.12 Published 2009 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 19556450 Disease Relevance 0.76 Pain Relevance 0.54

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