INT78969

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Context Info
Confidence 0.37
First Reported 1998
Last Reported 2008
Negated 0
Speculated 1
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 1.38
Pain Relevance 3.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Prkaca) nucleoplasm (Prkaca) mitochondrion (Prkaca)
Golgi apparatus (Prkaca) plasma membrane (Prkaca) nucleus (Prkaca)
Anatomy Link Frequency
neuronal 2
neurons 2
amygdala 2
Prkaca (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Kinase C 20 100.00 Very High Very High Very High
Dorsal column 62 99.84 Very High Very High Very High
amygdala 291 99.42 Very High Very High Very High
Visceral pain 26 98.76 Very High Very High Very High
Pain 213 98.72 Very High Very High Very High
Glutamate receptor 13 98.16 Very High Very High Very High
Neuronal excitability 3 97.68 Very High Very High Very High
Neurotransmitter 4 97.08 Very High Very High Very High
nMDA receptor 134 95.72 Very High Very High Very High
Action potential 7 95.40 Very High Very High Very High
Disease Link Frequency Relevance Heat
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super / Visceral Pain

27 98.76 Very High Very High Very High
Pain 211 98.72 Very High Very High Very High
Nociception 49 97.68 Very High Very High Very High
Arthritis 189 94.52 High High
Hypersensitivity 3 82.64 Quite High
Targeted Disruption 1 7.32 Low Low
INFLAMMATION 7 5.00 Very Low Very Low Very Low
Neuropathic Pain 7 5.00 Very Low Very Low Very Low
Anxiety Disorder 6 5.00 Very Low Very Low Very Low
Stress 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although other voltage-gated Na+ currents are modulated by the activation of protein kinase C (PKC), protein kinase A (PKA), or both, the second messenger pathways involved in the modulation of TTX-R INa are still being defined.
Regulation (modulated) of Positive_regulation (activation) of PKA associated with kinase c
1) Confidence 0.37 Published 1998 Journal J. Neurosci. Section Abstract Doc Link 9852572 Disease Relevance 0.10 Pain Relevance 0.34
A variety of neuromodulator/neurotransmitter receptors, including metabotropic glutamate receptors that are important for pain-related plasticity in the amygdala [12,16], have been shown to couple to ERK activation via PKA and PKC [61].
Regulation (couple) of Positive_regulation (activation) of PKA in amygdala associated with pain, neurotransmitter, glutamate receptor and amygdala
2) Confidence 0.24 Published 2008 Journal Mol Pain Section Body Doc Link PMC2490682 Disease Relevance 0.28 Pain Relevance 0.85
The effect of PKA activation by forskolin does not depend on ERK
Regulation (effect) of Positive_regulation (activation) of PKA
3) Confidence 0.24 Published 2008 Journal Mol Pain Section Body Doc Link PMC2490682 Disease Relevance 0.31 Pain Relevance 0.23
The effects of PKA and PKC activators were blocked by inhibitors of ERK signaling, suggesting that PKA and PKC act as upstream activators of ERK [39,40].
Regulation (effects) of Positive_regulation (activators) of PKA
4) Confidence 0.24 Published 2008 Journal Mol Pain Section Body Doc Link PMC2490682 Disease Relevance 0.54 Pain Relevance 0.90
The aim of this study was to analyse the possible influence of cyclic AMP-protein kinase A (cAMP-PKA) activation on neuronal nitric oxide (NO) release induced by electrical field stimulation in mesenteric arteries from Wistar Kyoto (WKY) rats.
Spec (possible) Regulation (influence) of Spec (possible) Positive_regulation (activation) of PKA in neuronal
5) Confidence 0.20 Published 2004 Journal Eur. J. Pharmacol. Section Abstract Doc Link 15033389 Disease Relevance 0 Pain Relevance 0.06
Another important role for the activation of PKA in PSDC neurons is that PKA may mediate painful stimulation-elicited gene expression through its regulation of transcription factors, such as c-fos and CREB [33,35,40,45].
Regulation (role) of Positive_regulation (activation) of PKA in neurons associated with pain and dorsal column
6) Confidence 0.06 Published 2008 Journal Mol Pain Section Body Doc Link PMC2584043 Disease Relevance 0.07 Pain Relevance 0.90

General Comments

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