INT78970

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Context Info
Confidence 0.47
First Reported 1998
Last Reported 2010
Negated 1
Speculated 4
Reported most in Abstract
Documents 14
Total Number 18
Disease Relevance 3.06
Pain Relevance 11.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Prkaca) nucleoplasm (Prkaca) mitochondrion (Prkaca)
Golgi apparatus (Prkaca) plasma membrane (Prkaca) nucleus (Prkaca)
Anatomy Link Frequency
neurons 4
astrocytes 4
spinal 2
sensory neurons 2
brain 2
Prkaca (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Kinase C 68 100.00 Very High Very High Very High
Dorsal column 62 100.00 Very High Very High Very High
agonist 19 100.00 Very High Very High Very High
Dopamine 4 100.00 Very High Very High Very High
nMDA receptor 99 99.84 Very High Very High Very High
Morphine 100 99.60 Very High Very High Very High
Codeine 4 99.44 Very High Very High Very High
Dorsal horn neuron 13 99.16 Very High Very High Very High
Spinal nerve ligature 58 99.04 Very High Very High Very High
tolerance 24 98.90 Very High Very High Very High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 3 100.00 Very High Very High Very High
Ganglion Cysts 31 99.76 Very High Very High Very High
Neuropathic Pain 108 98.56 Very High Very High Very High
Arthritis 130 96.16 Very High Very High Very High
Pain 202 90.48 High High
Nociception 62 85.80 High High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super / Visceral Pain

28 84.08 Quite High
Targeted Disruption 2 77.76 Quite High
Overdose 1 70.00 Quite High
Nervous System Injury 4 67.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results strongly suggest that a PKA mediated triggering and enhancement of SMPO may be responsible for the excitatory effects of NE on sensory neurons in neuropathic rats.
Positive_regulation (mediated) of Positive_regulation (triggering) of PKA in sensory neurons associated with neuropathic pain
1) Confidence 0.47 Published 2003 Journal Pain Section Abstract Doc Link 14499434 Disease Relevance 0.33 Pain Relevance 0.38
Activation of either PKC or PKA increased TTX-R INa.
Positive_regulation (increased) of Positive_regulation (Activation) of PKA associated with kinase c
2) Confidence 0.41 Published 1998 Journal J. Neurosci. Section Abstract Doc Link 9852572 Disease Relevance 0.09 Pain Relevance 0.41
Results suggest that activation of the cAMP-PKA pathway by dopamine acting at D1-like receptors in the frontal cortex is necessary for working memory.
Positive_regulation (necessary) of Positive_regulation (activation) of PKA in frontal cortex associated with dopamine and urological neuroanatomy
3) Confidence 0.38 Published 2001 Journal Behav. Neurosci. Section Abstract Doc Link 11770052 Disease Relevance 0.18 Pain Relevance 0.43
We examined whether 8-bromo-cAMP (8-Br-cAMP)-induced modification of tetrodotoxin-resistant (TTX-R) sodium current in neonatal rat nodose ganglion neurons is mediated by the activation of protein kinase A (PKA) and/or protein kinase C (PKC).
Positive_regulation (mediated) of Positive_regulation (activation) of PKA in neurons associated with ganglion cysts, tetrodotoxin and kinase c
4) Confidence 0.28 Published 2007 Journal Neuropharmacology Section Abstract Doc Link 17140607 Disease Relevance 0.17 Pain Relevance 0.43
These results suggest that the 8-Br-cAMP-induced increase in Nav 1.8 currents may be mediated by activation of both PKA and PKC.
Spec (may) Positive_regulation (mediated) of Positive_regulation (activation) of PKA associated with kinase c
5) Confidence 0.28 Published 2007 Journal Neuropharmacology Section Abstract Doc Link 17140607 Disease Relevance 0.07 Pain Relevance 0.24
PKA activation by forskolin under normal conditions induces an NMDA receptor-mediated synaptic component that mimics synaptic facilitation observed in the arthritis model.
Positive_regulation (induces) of Positive_regulation (activation) of PKA associated with nmda receptor and arthritis
6) Confidence 0.27 Published 2008 Journal Mol Pain Section Body Doc Link PMC2490682 Disease Relevance 0.62 Pain Relevance 0.70
The effect of PKA activation by forskolin does not depend on ERK
Neg (not) Positive_regulation (on) of Positive_regulation (activation) of PKA
7) Confidence 0.27 Published 2008 Journal Mol Pain Section Body Doc Link PMC2490682 Disease Relevance 0.31 Pain Relevance 0.26
These results suggest that activation of CaMKII, PKA, and PKC may be crucial for the induction and the early-phase but not for the late-phase maintenance of the spinal LTP.
Spec (may) Positive_regulation (crucial) of Positive_regulation (activation) of PKA in spinal associated with kinase c and long-term potentiation
8) Confidence 0.22 Published 2004 Journal J. Neurophysiol. Section Abstract Doc Link 14586032 Disease Relevance 0 Pain Relevance 1.02
PKA or PKC activators either alone or more effectively together induce pERK in superficial dorsal horn neurons.
Positive_regulation (induce) of Positive_regulation (activators) of PKA in dorsal horn associated with dorsal horn neuron
9) Confidence 0.18 Published 2004 Journal J. Neurosci. Section Abstract Doc Link 15385614 Disease Relevance 0 Pain Relevance 0.96
Such an upregulation of basal and stimulated PKA activity has been shown in other brain areas [1,30].


Positive_regulation (upregulation) of Positive_regulation (stimulated) of PKA in brain
10) Confidence 0.16 Published 2005 Journal Mol Pain Section Body Doc Link PMC1074357 Disease Relevance 0 Pain Relevance 1.26
It also suggests that activation of PKA in PSDC neurons might increase CREB-induced the expression of NK1 receptor and contribute to the sensitization of PSDC neurons (Figure 2).
Spec (might) Positive_regulation (increase) of Positive_regulation (activation) of PKA in neurons associated with dorsal column
11) Confidence 0.12 Published 2008 Journal Mol Pain Section Body Doc Link PMC2584043 Disease Relevance 0.20 Pain Relevance 0.91
Here, we demonstrate that the potency and efficacy of AEA at VR1 receptors can be significantly increased by the concomitant activation of protein kinase A (PKA).
Positive_regulation (increased) of Positive_regulation (activation) of PKA associated with potency
12) Confidence 0.09 Published 2001 Journal J. Neurochem. Section Abstract Doc Link 11413249 Disease Relevance 0 Pain Relevance 0.26
BDNF levels in astrocytes were increased by the specific beta1-adrenergic agonist dobutamine and the beta2-adrenergic agonist salbutamol, as well as by adenylate cyclase activation (by forskolin) and PKA activation (by dBcAMP).
Positive_regulation (activation) of Positive_regulation (activation) of PKA in astrocytes associated with agonist
13) Confidence 0.09 Published 2008 Journal Neurochem. Int. Section Abstract Doc Link 17681645 Disease Relevance 0 Pain Relevance 0.66
BDNF levels in astrocytes were increased by the specific beta1-adrenergic agonist dobutamine and the beta2-adrenergic agonist salbutamol, as well as by adenylate cyclase activation (by forskolin) and PKA activation (by dBcAMP).
Positive_regulation (increased) of Positive_regulation (activation) of PKA in astrocytes associated with agonist
14) Confidence 0.09 Published 2008 Journal Neurochem. Int. Section Abstract Doc Link 17681645 Disease Relevance 0 Pain Relevance 0.68
It was investigated the in vivo effect of glutethimide on the intracellular neuroadaptation characteristic for m-opioid receptor tolerance induced by chronic codeine treatment and reflected by increased levels of adenylyl cyclase (AC) and cAMP-dependent protein kinase (PKA).
Positive_regulation (increased) of Positive_regulation (levels) of PKA associated with tolerance, opioid receptor and codeine
15) Confidence 0.05 Published 2001 Journal J. Cell. Mol. Med. Section Abstract Doc Link 12067475 Disease Relevance 0.12 Pain Relevance 0.44
Finally, the contribution of other signalling pathways should not be ruled out as it has been verified that activation of the PKC and PKA pathways may lead to ERK phosphorylation [54, 108].
Spec (may) Positive_regulation (lead) of Positive_regulation (activation) of PKA associated with kinase c
16) Confidence 0.04 Published 2007 Journal Current Neuropharmacology Section Body Doc Link PMC2644492 Disease Relevance 0.12 Pain Relevance 0.56
Additionally, PKA activation mediates NR1 phosphorylation in SNL-induced neuropathic pain [28].
Positive_regulation (mediates) of Positive_regulation (activation) of PKA associated with spinal nerve ligature and neuropathic pain
17) Confidence 0.04 Published 2010 Journal Mol Pain Section Body Doc Link PMC2942826 Disease Relevance 0.67 Pain Relevance 1.69
Even though the ETAR can stimulate pathways leading to both PKA and PKC activation, receptor-mediated potentiation of TRPV1 in HEK293 cells was predominantly mediated by PKC.
Positive_regulation (leading) of Positive_regulation (activation) of PKA
18) Confidence 0.02 Published 2007 Journal Mol Pain Section Body Doc Link PMC2206006 Disease Relevance 0.08 Pain Relevance 0.21

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