INT78977

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Context Info
Confidence 0.62
First Reported 1998
Last Reported 2008
Negated 0
Speculated 1
Reported most in Abstract
Documents 3
Total Number 4
Disease Relevance 0.38
Pain Relevance 1.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Grin2c) plasma membrane (Grin2c) cytoplasm (Grin2c)
Anatomy Link Frequency
skin 1
interneurons 1
Grin2c (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Glutamate receptor 5 100.00 Very High Very High Very High
Inflammation 1 99.48 Very High Very High Very High
substance P 5 98.12 Very High Very High Very High
Calcitonin gene-related peptide 3 97.48 Very High Very High Very High
Spinal cord 2 96.44 Very High Very High Very High
substantia gelatinosa 2 95.68 Very High Very High Very High
projection neuron 4 94.80 High High
Somatostatin 8 94.72 High High
Pain 2 94.28 High High
nMDA receptor 5 94.08 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 1 99.48 Very High Very High Very High
Nociception 1 98.88 Very High Very High Very High
Pain 2 94.28 High High
Inflammatory Pain 2 89.08 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We used quantitative double-label in situ hybridization to examine in rat brain the expression of NMDAR1, NMDAR2A, NMDAR2B, and NMDAR2C mRNA in six neurochemically defined populations of striatal neurons: preproenkephalin (ENK) and preprotachykinin (SP) expressing projection neurons, and somatostatin (SOM), glutamic acid decarboxylase 67 (GAD67), parvalbumin (PARV), and choline acetyltransferase (ChAT) expressing interneurons.
Spec (examine) Gene_expression (expression) of NMDAR2C in interneurons associated with somatostatin and projection neuron
1) Confidence 0.62 Published 1999 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9889300 Disease Relevance 0 Pain Relevance 0.29
NMDAR2C expression was also observed in small cells not labeled by any of the markers, most likely glia.
Gene_expression (expression) of NMDAR2C
2) Confidence 0.62 Published 1999 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9889300 Disease Relevance 0 Pain Relevance 0.36
Activation of NMDA glutamate receptor, production of nitric oxide (NO), and enhanced release of substance P and calcitonin gene-related peptide (CGRP) from primary afferents are key events in pain perception and central hyperexcitability.
Gene_expression (production) of NMDA glutamate receptor associated with pain, glutamate receptor, hyperexcitability, calcitonin gene-related peptide and substance p
3) Confidence 0.32 Published 1998 Journal J. Neurosci. Section Abstract Doc Link 9852575 Disease Relevance 0.19 Pain Relevance 0.62
Inflammation-induced up-regulation of ionotropic glutamate receptor expression in human skin.
Gene_expression (expression) of ionotropic glutamate receptor in skin associated with inflammation and glutamate receptor
4) Confidence 0.04 Published 2008 Journal Br J Anaesth Section Title Doc Link 18238837 Disease Relevance 0.19 Pain Relevance 0.32

General Comments

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