INT78978

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Context Info
Confidence 0.51
First Reported 1998
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 0.46
Pain Relevance 2.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Grin2c) plasma membrane (Grin2c) cytoplasm (Grin2c)
Anatomy Link Frequency
neuronal 1
auditory cortex 1
skin 1
Grin2c (Rattus norvegicus)
Pain Link Frequency Relevance Heat
dopamine receptor 22 100.00 Very High Very High Very High
Glutamate receptor 6 100.00 Very High Very High Very High
Morphine 9 99.84 Very High Very High Very High
gABA 5 99.62 Very High Very High Very High
Glutamate 4 99.00 Very High Very High Very High
Dopamine 27 98.14 Very High Very High Very High
substance P 5 97.64 Very High Very High Very High
Calcitonin gene-related peptide 3 97.00 Very High Very High Very High
Spinal cord 2 97.00 Very High Very High Very High
IPN 2 96.72 Very High Very High Very High
Disease Link Frequency Relevance Heat
Nociception 1 99.44 Very High Very High Very High
Apoptosis 1 98.98 Very High Very High Very High
Inflammatory Pain 2 96.72 Very High Very High Very High
Pain 2 93.80 High High
INFLAMMATION 1 75.00 Quite High
Shock 10 5.00 Very Low Very Low Very Low
Depression 3 5.00 Very Low Very Low Very Low
Body Weight 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the core, neuronal apoptotic inhibitory protein (NAIP), GABA-A alpha1 subunit, GRIN2C, GRIA1, mGluR1, D4 dopamine receptor and PSD-95 were upregulated by morphine administration whereas bax, bcl-x, cox-1 and MAP2 were decreased.
Positive_regulation (upregulated) of GRIN2C in neuronal associated with gaba, dopamine receptor, apoptosis and morphine
1) Confidence 0.51 Published 2004 Journal Neuroscience Section Abstract Doc Link 15183518 Disease Relevance 0.10 Pain Relevance 1.32
Activation of NMDA glutamate receptor, production of nitric oxide (NO), and enhanced release of substance P and calcitonin gene-related peptide (CGRP) from primary afferents are key events in pain perception and central hyperexcitability.
Positive_regulation (Activation) of NMDA glutamate receptor associated with pain, glutamate receptor, hyperexcitability, calcitonin gene-related peptide and substance p
2) Confidence 0.37 Published 1998 Journal J. Neurosci. Section Abstract Doc Link 9852575 Disease Relevance 0.19 Pain Relevance 0.61
In the rat auditory cortex, dopamine is involved in the modulation of glutamate release (Atzori et al. 2005), and in the gerbil, NMDA-type glutamate receptor activity is required for auditory cortex-dependent memory (Schicknick and Tischmeyer 2006).
Positive_regulation (required) of NMDA-type glutamate receptor in auditory cortex associated with glutamate, dopamine and glutamate receptor
3) Confidence 0.04 Published 2008 Journal Cerebral Cortex (New York, NY) Section Body Doc Link PMC2567422 Disease Relevance 0 Pain Relevance 0.26
BACKGROUND: N-methyl-D-aspartate (NMDA), alpha-amino-3-hydroxy-5-methylisoxazolone-4-propionic acid (AMPA), and kainate (KA) receptors are members of the ionotropic glutamate receptor (iGluR) family and are increased in inflamed rat skin.
Positive_regulation (increased) of ionotropic glutamate receptor in skin associated with glutamate receptor
4) Confidence 0.03 Published 2008 Journal Br J Anaesth Section Abstract Doc Link 18238837 Disease Relevance 0.17 Pain Relevance 0.31

General Comments

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