INT7898

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Context Info
Confidence 0.78
First Reported 1991
Last Reported 2010
Negated 0
Speculated 5
Reported most in Body
Documents 123
Total Number 128
Disease Relevance 31.52
Pain Relevance 53.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Homer1) cytoplasm (Homer1)
Anatomy Link Frequency
neurons 11
hippocampus 8
brain 7
neuronal 7
striatum 6
Homer1 (Mus musculus)
Pain Link Frequency Relevance Heat
Opioid 51 100.00 Very High Very High Very High
Enkephalin 51 100.00 Very High Very High Very High
substance P 17 100.00 Very High Very High Very High
qutenza 16 100.00 Very High Very High Very High
Neuropeptide 11 100.00 Very High Very High Very High
cocaine 116 99.96 Very High Very High Very High
imagery 160 99.92 Very High Very High Very High
antagonist 130 99.92 Very High Very High Very High
agonist 57 99.92 Very High Very High Very High
Morphine 190 99.84 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pseudorabies 20 100.00 Very High Very High Very High
Attention Deficit Hyperactivity Disorder 9 99.90 Very High Very High Very High
Targeted Disruption 166 99.88 Very High Very High Very High
Depression 107 99.78 Very High Very High Very High
Amputation 1 99.78 Very High Very High Very High
INFLAMMATION 135 99.46 Very High Very High Very High
Pain 118 99.40 Very High Very High Very High
Injury 182 99.38 Very High Very High Very High
Infection 24 99.12 Very High Very High Very High
Cv Unclassified Under Development 2 99.12 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, we observed that targeted gene transfer of Homer1a to specific spinal segments in vivo reduces inflammatory hyperalgesia.
Gene_expression (transfer) of Homer1a in spinal associated with hyperalgesia and inflammation
1) Confidence 0.78 Published 2006 Journal Nat. Med. Section Abstract Doc Link 16715092 Disease Relevance 0.89 Pain Relevance 1.06
Low Vesl-1 expression levels were detected in the CA2 area of the hippocampus, the olfactory bulb, the brain stem, and the cerebellum; thus, we successfully generated short-form-specific KO mice in which the expression of Vesl-1L protein was unaltered.


Gene_expression (expression) of Vesl-1L in hippocampus associated with hippocampus
2) Confidence 0.78 Published 2009 Journal Mol Brain Section Body Doc Link PMC2663561 Disease Relevance 0.44 Pain Relevance 0.13
Vesl-1S overexpression by in vivo AAV virus infection in rat hippocampus leads to impaired ability in the water maze test [22].
Gene_expression (overexpression) of Vesl-1S in hippocampus associated with hippocampus and infection
3) Confidence 0.78 Published 2009 Journal Mol Brain Section Body Doc Link PMC2663561 Disease Relevance 0.25 Pain Relevance 0.16
Regions that expressed Vesl-1L protein at high levels included the cortex, the CA1, the CA3, and the dentate gyrus of the hippocampus, the subiculum, and the inferior colliculus.
Gene_expression (expressed) of Vesl-1L in hippocampus associated with hippocampus
4) Confidence 0.78 Published 2009 Journal Mol Brain Section Body Doc Link PMC2663561 Disease Relevance 0.30 Pain Relevance 0.13
Vesl-1S expression triggers the translocation of mGluR5 to both the dendrites and axons of cultured cerebellar granule cells [42].
Gene_expression (expression) of Vesl-1S in dendrites
5) Confidence 0.78 Published 2009 Journal Mol Brain Section Body Doc Link PMC2663561 Disease Relevance 0.06 Pain Relevance 0.09
Low Vesl-1 expression levels were detected in the CA2 area of the hippocampus, the olfactory bulb, the brain stem, and the cerebellum; thus, we successfully generated short-form-specific KO mice in which the expression of Vesl-1L protein was unaltered.


Gene_expression (expression) of Vesl-1 in hippocampus associated with hippocampus
6) Confidence 0.78 Published 2009 Journal Mol Brain Section Body Doc Link PMC2663561 Disease Relevance 0.31 Pain Relevance 0.14
Finally, basic cellular mechanisms, such as immediate early gene expression and transcription factor activation, may involve processes that may be susceptible to modification by sedative agents.
Gene_expression (expression) of immediate early gene
7) Confidence 0.74 Published 1994 Journal Clin Intensive Care Section Abstract Doc Link 10150551 Disease Relevance 0.41 Pain Relevance 0.16
Given that the pontine parabrachial nucleus has been implicated in nociceptive as well as antinociceptive processes and is reciprocally connected with the spinal cord dorsal horn, it seems likely that peripheral inflammation will cause alterations in immediate early gene expression in this nucleus.
Gene_expression (expression) of immediate early gene in parabrachial nucleus associated with nociception, inflammation, dorsal horn, antinociceptive, spinal cord and parabrachial
8) Confidence 0.74 Published 1996 Journal J. Comp. Neurol. Section Abstract Doc Link 8907357 Disease Relevance 0.69 Pain Relevance 0.65
The expression of the immediate early gene, c-fos, was used to determine the distribution of brainstem neurons activated by stimulation of the distal hypoglossal nerve (XIIn) trunk.
Gene_expression (expression) of immediate early gene in brainstem associated with medulla
9) Confidence 0.74 Published 2000 Journal Somatosens Mot Res Section Abstract Doc Link 10994593 Disease Relevance 0 Pain Relevance 0.08
We report here, using the technique of the noxious stimulus-evoked expression of the immediate-early gene, c-fos, that neurons within this same ventrolateral periaqueductal gray region are selectively activated by a range of deep somatic and visceral nociceptive manipulations.
Gene_expression (expression) of immediate-early gene in neurons associated with nociception and central grey
10) Confidence 0.74 Published 1994 Journal Neuroscience Section Abstract Doc Link 7838371 Disease Relevance 1.26 Pain Relevance 0.77
Previously, we showed that unilateral blockade of D1 dopamine receptors in the striatum inhibits immediate-early gene expression bilaterally throughout large parts of the cortex, including sensory-evoked expression in the barrel cortex.
Gene_expression (expression) of immediate-early gene in barrel cortex associated with dopamine receptor
11) Confidence 0.74 Published 2001 Journal Eur. J. Neurosci. Section Abstract Doc Link 11703467 Disease Relevance 0 Pain Relevance 0.21
Immunocytochemical methods were used to localize the protein product of the immediate-early gene, c-fos, in male rats after exposure to, or direct physical interaction with, oestrous females.
Gene_expression (product) of immediate-early gene
12) Confidence 0.74 Published 1992 Journal Neuroscience Section Abstract Doc Link 1436507 Disease Relevance 0.15 Pain Relevance 0.17
Western blot analysis revealed that the level of Vesl-1L protein did not increase after the application of a maximum electroconvulsive shock (MECS) in the hippocampus of KO mice and was comparable to that of wild type mice in the condition where the level of Vesl-1S protein was increased (Figure 2c).
Gene_expression (protein) of Vesl-1L in hippocampus associated with shock and hippocampus
13) Confidence 0.67 Published 2009 Journal Mol Brain Section Body Doc Link PMC2663561 Disease Relevance 0.19 Pain Relevance 0.11
Histological sections of lumbar spinal cord were stained for immunoreactivity of the immediate-early-gene (IEG), c-fos, in three rats that received repeated threshold noxious radiant heat stimulation during the period of nocifensive hyperreflexia induced by 30 mg x kg(-1) pentobarbital ip.
Gene_expression (immunoreactivity) of immediate-early-gene in spinal cord
14) Confidence 0.64 Published 2000 Journal Can J Anaesth Section Body Doc Link 10930210 Disease Relevance 0.08 Pain Relevance 0
In situ hybridization was used to assess regional levels of four immediate early gene messenger RNA levels (c-fos, c-jun, junB, and a nerve growth factor induced gene, NGFI-A).
Gene_expression (levels) of immediate early gene messenger RNA in nerve associated with nerve growth factor
15) Confidence 0.63 Published 1993 Journal Neuroscience Section Abstract Doc Link 8255428 Disease Relevance 0.10 Pain Relevance 0.15
These mice were expected to produce Vesl-1L protein, but not Vesl-1S and Vesl-1M proteins.
Gene_expression (produce) of Vesl-1S
16) Confidence 0.60 Published 2009 Journal Mol Brain Section Body Doc Link PMC2663561 Disease Relevance 0.23 Pain Relevance 0.03
Expression of the Vesl-1L protein in homozygous mice was similar to that of wild type mice in terms of brain region specificity and expression levels; thus, we conclude that the homozygous mice were indeed short-form-specific KO mice with normal Vesl-1 long form function.
Gene_expression (Expression) of Vesl-1L in brain
17) Confidence 0.60 Published 2009 Journal Mol Brain Section Body Doc Link PMC2663561 Disease Relevance 0.37 Pain Relevance 0
In this study, we successfully generated short form Vesl-1-specific KO mice without affecting the expression of the long form of Vesl-1, which is a splicing isoform of the vesl-1 gene.
Gene_expression (expression) of vesl-1
18) Confidence 0.60 Published 2009 Journal Mol Brain Section Body Doc Link PMC2663561 Disease Relevance 0.33 Pain Relevance 0
In this study, we successfully generated short form Vesl-1-specific KO mice without affecting the expression of the long form of Vesl-1, which is a splicing isoform of the vesl-1 gene.
Gene_expression (expression) of Vesl-1
19) Confidence 0.60 Published 2009 Journal Mol Brain Section Body Doc Link PMC2663561 Disease Relevance 0.33 Pain Relevance 0
These mice were expected to produce Vesl-1L protein, but not Vesl-1S and Vesl-1M proteins.
Gene_expression (produce) of Vesl-1M
20) Confidence 0.60 Published 2009 Journal Mol Brain Section Body Doc Link PMC2663561 Disease Relevance 0.23 Pain Relevance 0.03

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