INT78981

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Context Info
Confidence 0.44
First Reported 1998
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 6
Total Number 8
Disease Relevance 3.89
Pain Relevance 4.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Ntrk1) endosome (Ntrk1) aging (Ntrk1)
plasma membrane (Ntrk1) cytoplasm (Ntrk1)
Anatomy Link Frequency
nerve 2
neurons 1
spinal cord 1
Ntrk1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 4 99.96 Very High Very High Very High
spinal dorsal horn 5 99.68 Very High Very High Very High
Nerve growth factor 5 99.64 Very High Very High Very High
dorsal root ganglion 115 98.80 Very High Very High Very High
Dorsal horn 3 98.30 Very High Very High Very High
opiate 5 98.00 Very High Very High Very High
Neuropathic pain 6 97.64 Very High Very High Very High
Hsan 8 97.52 Very High Very High Very High
withdrawal 7 97.16 Very High Very High Very High
Spinal cord 48 96.20 Very High Very High Very High
Disease Link Frequency Relevance Heat
Ganglion Cysts 117 98.80 Very High Very High Very High
Apoptosis 49 97.76 Very High Very High Very High
Neuropathic Pain 7 97.64 Very High Very High Very High
Hereditary Sensory And Autonomic Neuropathies 8 97.52 Very High Very High Very High
Cystitis 4 96.92 Very High Very High Very High
Hypohidrosis 1 96.44 Very High Very High Very High
Death 24 96.00 Very High Very High Very High
INFLAMMATION 94 95.20 Very High Very High Very High
Disease 5 93.60 High High
Spinal Cord Injury 58 92.12 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover, Takahara et al. [32] reported that the expression of PAP-I was up-regulated in both IB4-positive and TrkA-positive (peptidergic) small DRG neurons following cyclophosphamide-induced cystitis.
Regulation (regulated) of TrkA in neurons associated with dorsal root ganglion and cystitis
1) Confidence 0.44 Published 2010 Journal Mol Pain Section Body Doc Link PMC2873504 Disease Relevance 1.81 Pain Relevance 1.01
Even though our present study revealed a down-regulation of three receptors of the GDNF family [78,79] and Ntrk1, genes for other growth factor receptors that did not demonstrate a change in expression may provide clues as to which neurotrophic agents might prove useful for LDPT axonal regeneration.
Regulation (regulation) of Ntrk1
2) Confidence 0.36 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC3001741 Disease Relevance 0.26 Pain Relevance 0.07
A few years ago, point mutations affecting both coding and noncoding regions of the neurotrophic tyrosine receptor kinase type 1 (NTRK1)/nerve growth factor receptor gene have been detected in CIPA patients, demonstrating the implication of the nerve growth factor/NTRK1 pathway in the pathogenesis of the disease.
Regulation (affecting) of neurotrophic tyrosine receptor kinase type 1 in nerve associated with nerve growth factor, disease and hsan
3) Confidence 0.34 Published 2002 Journal J. Biol. Chem. Section Abstract Doc Link 11719521 Disease Relevance 0.88 Pain Relevance 0.74
Additionally the down-regulation of the NGF receptor, Ntrk1 (TrkA) argues against the use of nerve growth factor (NGF) as a potential therapeutic agent.
Regulation (regulation) of Ntrk1 in nerve associated with nerve growth factor
4) Confidence 0.22 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC3001741 Disease Relevance 0.35 Pain Relevance 0.13
This paper explores the role of BDNF in this process, using the effect of a Trk antagonist (K252a) on the labelling of progenitor cells with the mitosis marker Ki67 and the associated expression of pCREB and Wnt3a.
Regulation (effect) of Trk associated with antagonist
5) Confidence 0.12 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2965105 Disease Relevance 0.08 Pain Relevance 0.61
It should be noted that few of these inhibitors are Trk selective, demonstrating that targeting Trk kinases for treatment of pain and/or cancer offers a promising but also challenging approach.


Regulation (targeting) of Trk
6) Confidence 0.08 Published 2009 Journal Expert Opin Ther Pat Section Body Doc Link 19441906 Disease Relevance 0.15 Pain Relevance 0
To determine whether the spinal cord BDNF contributes to the development and maintenance of neuropathic pain by activation of the dorsal horn NR2B-containing NMDA (NMDA-2B) receptors, this study was designed to investigate if alterations in BDNF and its TrkB receptor in the spinal dorsal horn would parallel the timeline of the development of neuropathic pain in lumbar 5 (L5) spinal nerve ligated (SNL) rats.
Spec (investigate) Regulation (alterations) of TrkB receptor in spinal cord associated with spinal dorsal horn, dorsal horn, neuropathic pain and spinal cord
7) Confidence 0.03 Published 2010 Journal Exp. Neurol. Section Abstract Doc Link 20079352 Disease Relevance 0.27 Pain Relevance 0.76
Differential regulation of neurotrophin and trk receptor mRNAs in catecholaminergic nuclei during chronic opiate treatment and withdrawal.
Regulation (regulation) of trk receptor associated with opiate and withdrawal
8) Confidence 0.00 Published 1998 Journal J. Neurosci. Section Title Doc Link 9852605 Disease Relevance 0.09 Pain Relevance 1.20

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