INT78990

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Context Info
Confidence 0.57
First Reported 1998
Last Reported 2010
Negated 13
Speculated 5
Reported most in Abstract
Documents 72
Total Number 77
Disease Relevance 35.22
Pain Relevance 18.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Cpox) oxidoreductase activity (Cpox) cytoplasm (Cpox)
Anatomy Link Frequency
cerebral cortex 4
liver 2
colon 2
macrophages 1
brain 1
Cpox (Mus musculus)
Pain Link Frequency Relevance Heat
cINOD 559 100.00 Very High Very High Very High
Hippocampus 175 100.00 Very High Very High Very High
cerebral cortex 156 100.00 Very High Very High Very High
COX-2 inhibitor 118 100.00 Very High Very High Very High
cytokine 250 99.76 Very High Very High Very High
COX2 17 99.76 Very High Very High Very High
cOX1 15 99.76 Very High Very High Very High
Inflammation 495 99.64 Very High Very High Very High
metalloproteinase 113 99.40 Very High Very High Very High
aspirin 112 99.34 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 666 100.00 Very High Very High Very High
Alzheimer's Dementia 22 100.00 Very High Very High Very High
Fever 19 99.88 Very High Very High Very High
Adenocarcinoma 48 99.80 Very High Very High Very High
Breast Cancer 306 99.74 Very High Very High Very High
Disease 334 99.48 Very High Very High Very High
Polyps 8 99.46 Very High Very High Very High
Encephalitis 6 99.36 Very High Very High Very High
Colon Cancer 180 99.32 Very High Very High Very High
Aberrant Crypt Foci 12 99.24 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The discordant effects on beta amyloid and cyclooxygenase (COX) suggest that these effects of nonsteroidal anti-inflammatory drugs (NSAIDs) are not causally linked.
Regulation (effects) of COX associated with inflammation, alzheimer's dementia and cinod
1) Confidence 0.57 Published 2003 Journal J. Neuroimmunol. Section Abstract Doc Link 12667645 Disease Relevance 1.14 Pain Relevance 0.36
This study was aimed at defining the role of cycl-oxygenase (COX) inhibitors on nitric oxide (NO) production in murine macrophages in vitro.
Regulation (role) of COX in macrophages
2) Confidence 0.42 Published 2001 Journal J Pak Med Assoc Section Abstract Doc Link 11255995 Disease Relevance 0.28 Pain Relevance 0.18
A single hepatotoxic dose caused the selective induction of COX-2 mRNA and increased PGD2 and PGE2 levels within the livers of COX(+/+) male mice suggesting a role for COX-2 in this model of liver injury.
Regulation (role) of COX in liver associated with injury
3) Confidence 0.34 Published 2001 Journal Chem. Res. Toxicol. Section Abstract Doc Link 11743745 Disease Relevance 0.71 Pain Relevance 0.28
Recent studies have demonstrated that cyclooxygenase (COX) pathway might modulate the neurotransmission of gamma-aminobutyric acid and dopamine in the central nervous system.
Spec (might) Regulation (modulate) of COX in central nervous system associated with dopamine and central nervous system
4) Confidence 0.32 Published 2006 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 17049975 Disease Relevance 0 Pain Relevance 0.37
Whereas lipopolysaccharide (LPS)-induced fever is attenuated in COX-2 gene-deleted mice, suggesting that COX-2 is responsible for this type of fever, the COX-1 gene may also be important in temperature regulation and in mediating the pyresis that occurs in the absence of infection.
Regulation (regulation) of COX associated with fever and infection
5) Confidence 0.30 Published 2003 Journal Thromb. Res. Section Abstract Doc Link 14592546 Disease Relevance 0.48 Pain Relevance 0.69
Diphenylamine and N-phenylanthranilic acid neither affected COX activity in platelets nor modified the activation state of neutrophils.
Neg (neither) Regulation (affected) of COX in neutrophils
6) Confidence 0.28 Published 2002 Journal J. Biol. Chem. Section Abstract Doc Link 12147693 Disease Relevance 0.55 Pain Relevance 0.69
receptor to up-regulate COX-2–dependent prostacyclin (PGI2) formation which, acting via its receptor (the I prostanoid receptor) constrains both platelet activation and oxidant stress.
Regulation (regulate) of COX in platelet associated with stress
7) Confidence 0.26 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1872041 Disease Relevance 0.50 Pain Relevance 0
Inhibitory studies demonstrated an apparent increased sensitivity of COX activity to the action of inhibitors when measuring intracellular PGE2 compared with using cell culture supernatants.
Regulation (sensitivity) of COX
8) Confidence 0.26 Published 1999 Journal Anal. Biochem. Section Abstract Doc Link 10361000 Disease Relevance 0.15 Pain Relevance 0.40
Aspirin had no effect on PGE2 production and minimal inhibitory effect on COX activity.
Neg (no) Regulation (effect) of COX
9) Confidence 0.22 Published 2003 Journal Anticancer Res. Section Body Doc Link 12680248 Disease Relevance 0.08 Pain Relevance 0
Kinetic experiments with A23187-stimulated mouse 3T3 fibroblast cells revealed a distinct biphasic response in COX activity.
Regulation (response) of COX in fibroblast
10) Confidence 0.22 Published 1999 Journal Anal. Biochem. Section Abstract Doc Link 10361000 Disease Relevance 0.16 Pain Relevance 0.43
[Current topics in the regulation of prostanoids-1.
Regulation (regulation) of COX associated with cox1
11) Confidence 0.22 Published 1998 Journal Masui Section Title Doc Link 9852696 Disease Relevance 0.47 Pain Relevance 0.44
These data demonstrate that NAG-1 is an antitumorigenic and proapoptotic protein, and its regulation by COX inhibitors may provide new clues for explaining their proapoptotic and antitumorigenic activities.
Regulation (regulation) of COX
12) Confidence 0.22 Published 2001 Journal Mol. Pharmacol. Section Abstract Doc Link 11259636 Disease Relevance 0.39 Pain Relevance 0.53
To address this question, we examined the effects of COX-2 inhibition on prostate tumorigenesis in the transgenic adenocarcinoma mouse prostate (TRAMP) model.
Spec (examined) Regulation (effects) of COX associated with adenocarcinoma and targeted disruption
13) Confidence 0.20 Published 2008 Journal Carcinogenesis Section Abstract Doc Link 17942462 Disease Relevance 0.63 Pain Relevance 0.13
This effect was not seen in all NSAIDs and seems not to be mediated by inhibition of cyclooxygenase (COX) activity, the principal pharmacological target of NSAIDs.
Regulation (target) of COX associated with cinod
14) Confidence 0.18 Published 2001 Journal Nature Section Abstract Doc Link 11700559 Disease Relevance 0.48 Pain Relevance 0.82
Protective effect of cyclooxygenase-2 (COX-2) inhibitors but not non-selective cyclooxygenase (COX)-inhibitors on ethanol withdrawal-induced behavioural changes.
Regulation (effect) of COX associated with withdrawal
15) Confidence 0.17 Published 2005 Journal Addict Biol Section Title Doc Link 16318954 Disease Relevance 0.08 Pain Relevance 0.35
Thus we investigated healing and regulation of COX and NOS isoforms during ulcer healing in COX-1 and COX-2 deficiency and inhibition mouse models.
Spec (investigated) Regulation (regulation) of COX associated with ulcers
16) Confidence 0.17 Published 2006 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 16373427 Disease Relevance 0.61 Pain Relevance 0.11
COX genotype-dependent alteration of Janus kinase isoforms in the mouse hippocampus
Regulation (alteration) of COX in hippocampus associated with hippocampus
17) Confidence 0.16 Published 2007 Journal Genome Biol Section Body Doc Link PMC1839133 Disease Relevance 0.20 Pain Relevance 0.36
After 24 h, the anti-infarct effect was associated with enhanced myocardial levels of COX-2, PGE2, and 6-keto-PGF(1-alpha), and no changes in COX-1 protein levels were found.
Neg (no) Regulation (changes) of COX
18) Confidence 0.15 Published 2005 Journal J. Am. Coll. Cardiol. Section Body Doc Link 15893191 Disease Relevance 0 Pain Relevance 0
Concomitant use of aspirin at 75mg/d, which preferentially targets COX-1 for inhibition, was associated with an OR of 0.71 (95% CI 0.26–1.94) approximating that in aspirin nonusers (OR 0.77; 95% CI 0.59–1.00).
Regulation (targets) of COX associated with aspirin
19) Confidence 0.13 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1872041 Disease Relevance 0.23 Pain Relevance 0.23
Contrasting effects of cyclooxygenase-1 (COX-1) and COX-2 deficiency on the host response to influenza A viral infection.
Regulation (effects) of COX associated with influenza virus infection, viral infection and cox1
20) Confidence 0.13 Published 2005 Journal J. Immunol. Section Title Doc Link 16272346 Disease Relevance 1.07 Pain Relevance 0.59

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