INT78995

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Context Info
Confidence 0.42
First Reported 1995
Last Reported 2011
Negated 0
Speculated 1
Reported most in Abstract
Documents 26
Total Number 27
Disease Relevance 13.05
Pain Relevance 4.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Agtr2) transcription factor binding (Agtr2) signal transducer activity (Agtr2)
Anatomy Link Frequency
blood 4
platelet 1
lateral ventricles 1
Agtr2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 66 100.00 Very High Very High Very High
beta blocker 22 99.88 Very High Very High Very High
fluoxetine 1 99.76 Very High Very High Very High
headache 17 99.20 Very High Very High Very High
sSRI 2 99.20 Very High Very High Very High
aspirin 2 99.20 Very High Very High Very High
Chronic pancreatitis 2 98.88 Very High Very High Very High
cINOD 4 98.56 Very High Very High Very High
cytokine 3 98.50 Very High Very High Very High
Angina 5 98.20 Very High Very High Very High
Disease Link Frequency Relevance Heat
Coronary Heart Disease 8 99.76 Very High Very High Very High
Increased Venous Pressure Under Development 19 99.56 Very High Very High Very High
Pancreatitis 2 98.88 Very High Very High Very High
Hypertension 91 98.72 Very High Very High Very High
Diabetes Mellitus 36 98.40 Very High Very High Very High
INFLAMMATION 11 98.36 Very High Very High Very High
Obesity 38 98.34 Very High Very High Very High
Renal Disease 13 98.32 Very High Very High Very High
Ureteral Obstruction 5 98.32 Very High Very High Very High
Cough 8 98.24 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
[Inhibition of platelet aggregation and angiotensin II-receptor blockade following TIA; the unexpected results of the Prevention Regimen For Effectively Avoiding Second Strokes (PROFESS) trial].
Negative_regulation (blockade) of angiotensin II-receptor in platelet associated with aspirin and stroke
1) Confidence 0.42 Published 2008 Journal Ned Tijdschr Geneeskd Section Title Doc Link 18808078 Disease Relevance 0.72 Pain Relevance 0.26
We injected the AT1 and AT2 angiotensin II receptor antagonists, losartan and PD123319, L-NAME, 7-nitroindazole (nitric oxide synthetase inhibitors), and FK409 (nitric oxide donor agent) into the lateral ventricles.
Negative_regulation (antagonists) of AT2 in lateral ventricles
2) Confidence 0.35 Published 2007 Journal Anesth. Analg. Section Body Doc Link 17959957 Disease Relevance 0 Pain Relevance 0
We examined the renal cellular response to angiotensin II receptor inhibition in the neonatal rat subjected to partial UUO under anesthesia within 48 h of birth.
Spec (examined) Negative_regulation (inhibition) of angiotensin II receptor associated with ureteral obstruction and anesthesia
3) Confidence 0.35 Published 2007 Journal Am. J. Physiol. Renal Physiol. Section Abstract Doc Link 17442727 Disease Relevance 0.55 Pain Relevance 0.10
Zoletil anesthesia did not interfere with the effects of angiotensin II, AT1, AT2 antagonists, or nitric oxide synthetase inhibitors.
Negative_regulation (inhibitors) of AT2
4) Confidence 0.21 Published 2007 Journal Anesth. Analg. Section Body Doc Link 17959957 Disease Relevance 0 Pain Relevance 0
Olmesartan medoxomil is a nonpeptide angiotensin II receptor antagonist that selectively and competitively inhibits the type 1 angiotensin II receptor (Mizuno et al 1995).
Negative_regulation (inhibits) of angiotensin II receptor associated with antagonist
5) Confidence 0.17 Published 2006 Journal Vascular Health and Risk Management Section Body Doc Link PMC1994016 Disease Relevance 0.42 Pain Relevance 0.33
Losartan, candesartan, valsartan, which are AT1 receptor blockers (ARB); PD123319, an AT2 receptor blocker; enalapril, an ACE inhibitor; or diphenylene iodonium, a NADPH oxidase inhibitor, was given i.v. 10 mins, and beta-NADPH, a NADPH oxidase substrate, was given i.v. 5 mins before reperfusion.
Negative_regulation (blocker) of AT2 receptor
6) Confidence 0.17 Published 2010 Journal J. Physiol. Pharmacol. Section Abstract Doc Link 20436217 Disease Relevance 0.40 Pain Relevance 0.29
METHODS AND RESULTS: A meta-analysis was carried out of the 94 randomized placebo-controlled trials of 4 different classes of blood pressure-lowering drugs (thiazides, beta-blockers, ACE inhibitors, and angiotensin II receptor antagonists) in fixed doses in which data on headache were reported.
Negative_regulation (inhibitors) of angiotensin II receptor in blood
7) Confidence 0.17 Published 2005 Journal Circulation Section Body Doc Link 16216977 Disease Relevance 0.09 Pain Relevance 0
Moreover, inhibition of iNOS by NG-monomethyl-L-arginine mimicked AT2R inhibition in aortic vasodilation[34].
Negative_regulation (inhibition) of AT2R associated with increased venous pressure under development
8) Confidence 0.16 Published 2010 Journal Cancer Cell Int Section Body Doc Link PMC2902462 Disease Relevance 0.74 Pain Relevance 0.04
Previous studies have shown that diet induced obesity in rodent models can be prevented by angiotensin converting enzyme inhibitors and angiotensin II receptor blockers [29–32].
Negative_regulation (blockers) of angiotensin II receptor associated with obesity
9) Confidence 0.16 Published 2011 Journal Journal of Obesity Section Body Doc Link PMC2933895 Disease Relevance 1.20 Pain Relevance 0.17
The ANG II type 1 receptor was blocked with losartan (10 mg.kg(-1).day(-1)) to investigate a possible role of the renin-angiotensin system in regulation of natriuretic peptide and NPR gene expression.
Negative_regulation (blocked) of ANG II type 1 receptor associated with natriuresis
10) Confidence 0.15 Published 2006 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 16272201 Disease Relevance 0.88 Pain Relevance 0.25
Moreover the patient is later diagnosed with IN until de-hydratation or treatment with angiotensin converting enzyme inhibitors or angiotensin-2-receptor inhibitors.
Negative_regulation (inhibitors) of angiotensin-2-receptor associated with renal disease
11) Confidence 0.10 Published 2007 Journal Rev Med Chir Soc Med Nat Iasi Section Abstract Doc Link 17983174 Disease Relevance 1.14 Pain Relevance 0.16
Losartan, an angiotensin II receptor inhibitor, and fluoxetine, a selective serotonin reuptake inhibitor, have been beneficial for systemic sclerosis-associated Raynaud's phenomenon in pilot studies.
Negative_regulation (inhibitor) of angiotensin II receptor associated with systemic sclerosis, ssri and fluoxetine
12) Confidence 0.10 Published 2007 Journal Med. Klin. (Munich) Section Abstract Doc Link 17345017 Disease Relevance 1.01 Pain Relevance 0.30
Combination therapy with an angiotensin-converting enzyme inhibitor and an angiotensin II receptor blocker synergistically suppresses chronic pancreatitis in rats.
Negative_regulation (blocker) of angiotensin II receptor associated with chronic pancreatitis and cytokine
13) Confidence 0.10 Published 2005 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 15608084 Disease Relevance 0.48 Pain Relevance 0.37
Although there was no measurable difference in the risk of cardiovascular events according to the class of antihypertensives, statistically significant increases in the risk of cardiovascular events were observed for non-use of calcium antagonists among patients with angina pectoris and for non-use of the renin-angiotensin system inhibitor (angiotensin-converting enzyme inhibitor and angiotensin II receptor blockers combined) among patients with diabetes mellitus.
Negative_regulation (inhibitor) of angiotensin II receptor associated with angina, diabetes mellitus and antagonist
14) Confidence 0.09 Published 2005 Journal Hypertens. Res. Section Abstract Doc Link 16471175 Disease Relevance 0.54 Pain Relevance 0.15
ACE inhibitors or angiotensin II receptor blockers may be of use in case of comorbity (hypertension, diabetes or left ventricular dysfunction).
Negative_regulation (inhibitors) of angiotensin II receptor associated with left ventricular dysfunction, diabetes mellitus and hypertension
15) Confidence 0.07 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1920553 Disease Relevance 1.02 Pain Relevance 0.24
Angiotensin II receptor blockers, such as eprosartan, are as effective as ACE inhibitors in reducing blood pressure, but lack the main adverse effect of ACE inhibitors, namely cough.
Negative_regulation (blockers) of Angiotensin II receptor in blood associated with cough
16) Confidence 0.07 Published 2002 Journal Drug Saf Section Abstract Doc Link 12113644 Disease Relevance 0.09 Pain Relevance 0
In this study, we have investigated the oedematogenic activity of DMTI (20 kDa) and DMTI-II (23 kDa), two serine proteinases inhibitors isolated from Dimorphandra mollis (Leguminosae-Mimosoideae) seeds, belonging to the Kunitz family.
Negative_regulation (inhibitors) of DMTI-II
17) Confidence 0.07 Published 2006 Journal Toxicon Section Abstract Doc Link 16386283 Disease Relevance 0.32 Pain Relevance 0.12
CS-866, a novel angiotensin II receptor blocker, is rapidly and completely metabolized to RNH-6270, its active metabolite.
Negative_regulation (blocker) of angiotensin II receptor
18) Confidence 0.03 Published 2001 Journal J Clin Pharmacol Section Abstract Doc Link 11361048 Disease Relevance 0 Pain Relevance 0.03
Effect of indomethacin on the renal response to angiotensin II receptor blockade in healthy subjects.
Negative_regulation (blockade) of angiotensin II receptor
19) Confidence 0.03 Published 1998 Journal Kidney Int. Section Title Doc Link 9853274 Disease Relevance 0.19 Pain Relevance 0.19
Non-immunosuppressive therapy (i.e. angiotensin-converting enzyme inhibitors, angiotensin II receptor blockers, lipid-lowering drugs, non-steroidal anti-inflammatory drugs) should be applied to almost all patients with primary FSGS.
Negative_regulation (blockers) of angiotensin II receptor associated with inflammation, focal segmental glomerulosclerosis and cinod
20) Confidence 0.03 Published 2003 Journal Nephrol. Dial. Transplant. Section Abstract Doc Link 12817066 Disease Relevance 0.70 Pain Relevance 0.12

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