INT78999

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Context Info
Confidence 0.36
First Reported 1998
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 1.75
Pain Relevance 0.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (AKR1C1) oxidoreductase activity (AKR1C1) cytoplasm (AKR1C1)
Anatomy Link Frequency
DDH 1
liver 1
AKR1C1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 3 100.00 Very High Very High Very High
Osteoarthritis 71 93.60 High High
aspirin 1 81.88 Quite High
cINOD 3 81.32 Quite High
Pain 1 80.56 Quite High
Bile 1 53.40 Quite High
cOX1 1 25.00 Low Low
Disease Link Frequency Relevance Heat
INFLAMMATION 5 100.00 Very High Very High Very High
Genetic Predisposition To Disease 1 97.08 Very High Very High Very High
Osteoarthritis 71 93.60 High High
Disease 7 93.20 High High
Cleidocranial Dysplasia 5 90.68 High High
Canine Hip Dysplasia 47 89.08 High High
Pain 1 80.56 Quite High
Joint Instability 1 75.32 Quite High
Dog Diseases 2 55.36 Quite High
Spinal Cord Diseases 1 52.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
While this conformation allows endoperoxide formation between C-11 and C-9, it also implies that a subsequent conformational rearrangement must occur to allow formation of the C-8/C-12 bond and to position C-15 for attack by a second molecule of oxygen.
C-9 Binding (formation) of
1) Confidence 0.36 Published 2000 Journal Science Section Abstract Doc Link 10988074 Disease Relevance 0.08 Pain Relevance 0.20
The results suggest that the human liver 3alpha-hydroxysteroid dehydrogenase isoform possesses the two distinct sites, activator and inhibitor sites, to which anti-inflammatory 2-arylpropionates stereoselectively bind.
3alpha-hydroxysteroid dehydrogenase isoform Binding (bind) of in liver associated with inflammation
2) Confidence 0.22 Published 1998 Journal Biol. Pharm. Bull. Section Abstract Doc Link 9853403 Disease Relevance 0.17 Pain Relevance 0.11
A locus linked to DDH spanning a 4 Mb region on HSA17q21 was recently identified [13].
DDH Binding (linked) of in DDH
3) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2952589 Disease Relevance 1.49 Pain Relevance 0.26

General Comments

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