INT790

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Context Info
Confidence 0.68
First Reported 1978
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 22
Total Number 23
Disease Relevance 4.56
Pain Relevance 10.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitosis (Mastl) cytoskeleton (Mastl) nucleus (Mastl)
cell cycle (Mastl) cell division (Mastl) kinase activity (Mastl)
Anatomy Link Frequency
brain 3
hypothalamus 2
tail 1
dendritic cells 1
Mastl (Mus musculus)
Pain Link Frequency Relevance Heat
Delta-9-tetrahydrocannabinol 9 100.00 Very High Very High Very High
analgesia 37 99.98 Very High Very High Very High
Cannabinoid 244 99.96 Very High Very High Very High
antinociception 22 99.96 Very High Very High Very High
addiction 3 99.96 Very High Very High Very High
cocaine 11 99.92 Very High Very High Very High
Morphine 71 99.90 Very High Very High Very High
Catecholamine 9 99.78 Very High Very High Very High
Multiple sclerosis 4 99.78 Very High Very High Very High
Antinociceptive 12 99.72 Very High Very High Very High
Disease Link Frequency Relevance Heat
Demyelinating Disease 4 99.78 Very High Very High Very High
Hypothermia 19 99.28 Very High Very High Very High
Nociception 4 98.92 Very High Very High Very High
Catalepsy 12 97.76 Very High Very High Very High
Disease 6 97.36 Very High Very High Very High
Targeted Disruption 30 96.16 Very High Very High Very High
Bordatella Infection 5 95.80 Very High Very High Very High
Sprains And Strains 9 94.56 High High
Pain 5 91.36 High High
Amnesia 2 90.80 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Morphine produced greater increases in dopamine synthesis and was a more potent antinociceptive agent, while THC produced greater increases in norepinephrine synthesis and was a more potent hypothermic agent.
Gene_expression (produced) of THC associated with dopamine, antinociceptive and morphine
1) Confidence 0.68 Published 1978 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 97703 Disease Relevance 0.27 Pain Relevance 1.22
Naloxone pretreatment (1 mg/kg) partially antagonized the hypothermia and increase in catecholamine synthesis produced by THC.
Gene_expression (produced) of THC associated with hypothermia, catecholamine and narcan
2) Confidence 0.59 Published 1978 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 97703 Disease Relevance 0.26 Pain Relevance 1.22
Opening of the pyran ring of delta 9-tetrahydrocannabinol (THC) produces cannabidiol, a bicyclic cannabinoid devoid of many pharmacological properties produced by delta 8-THC or delta 9-THC.
Gene_expression (produced) of THC associated with cannabinoid
3) Confidence 0.56 Published 1992 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 1309872 Disease Relevance 0 Pain Relevance 0.13
Opening of the pyran ring of delta 9-tetrahydrocannabinol (THC) produces cannabidiol, a bicyclic cannabinoid devoid of many pharmacological properties produced by delta 8-THC or delta 9-THC.
Gene_expression (produced) of THC associated with cannabinoid
4) Confidence 0.56 Published 1992 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 1309872 Disease Relevance 0 Pain Relevance 0.13
Both morphine and THC produced antinociception, hypothermia, and increased catecholamine synthesis at 30 min after s.c. injection.
Gene_expression (produced) of THC associated with antinociception, hypothermia, catecholamine and morphine
5) Confidence 0.52 Published 1978 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 97703 Disease Relevance 0.26 Pain Relevance 1.14
Interestingly, the somatic manifestations of THC withdrawal were also significantly attenuated in mutant mice, suggesting that a cooperative action of MOR and DOR is required for the entire expression of THC dependence.
Gene_expression (expression) of THC associated with addiction and withdrawal
6) Confidence 0.52 Published 2003 Journal Eur. J. Neurosci. Section Abstract Doc Link 12534979 Disease Relevance 0.60 Pain Relevance 0.70
Although it can produce delta9-THC like discriminative stimulus effects in rats, anandamide also produces concomitant response rate decreasing effects, whereas with delta9-THC there is a better separation of these two behavioral effects.
Gene_expression (produce) of delta9-THC
7) Confidence 0.49 Published 1997 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 9408225 Disease Relevance 0.18 Pain Relevance 0.18
While anandamide failed to produce reliable substitution for delta9-THC and did not reduce response rates at doses up to 10 mg/kg, 2-methylarachidonyl-2'-fluoroethylamide (methylated fluoroanandamide), a putative stable analog of anandamide, produced full dose-dependent substitution for delta9-THC at doses that caused no significant changes in response rates.
Gene_expression (produce) of delta9-THC
8) Confidence 0.43 Published 1997 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 9408225 Disease Relevance 0.15 Pain Relevance 0.17
Although it can produce delta9-THC like discriminative stimulus effects in rats, anandamide also produces concomitant response rate decreasing effects, whereas with delta9-THC there is a better separation of these two behavioral effects.
Gene_expression (produce) of delta9-THC
9) Confidence 0.42 Published 1997 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 9408225 Disease Relevance 0.18 Pain Relevance 0.18
Both marijuana and delta9-THC produced comparable levels of antinociception, hypothermia, and catalepsy regardless of the route of administration, and these effects were blocked by pretreatment with the CB1 antagonist SR141716 [N-(piperidin-1-yl)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide HCl].
Gene_expression (produced) of delta9-THC associated with antinociception, hypothermia, catalepsy and antagonist
10) Confidence 0.32 Published 2005 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15831444 Disease Relevance 0.45 Pain Relevance 0.42
Both marijuana and delta9-THC produced comparable levels of antinociception, hypothermia, and catalepsy regardless of the route of administration, and these effects were blocked by pretreatment with the CB1 antagonist SR141716 [N-(piperidin-1-yl)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide HCl].
Gene_expression (produced) of delta9-THC associated with antinociception, hypothermia, catalepsy and antagonist
11) Confidence 0.27 Published 2005 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15831444 Disease Relevance 0.45 Pain Relevance 0.42
Although Delta(9)-tetrahydrocannabinol (THC) produces analgesia, its effects on nociceptive primary afferents are unknown.
Gene_expression (produces) of THC associated with nociception and analgesia
12) Confidence 0.22 Published 2002 Journal J. Neurosci. Section Abstract Doc Link 12040079 Disease Relevance 0.33 Pain Relevance 0.58
We have shown previously that CBD pretreatment of mice increases brain levels of THC and have now further characterized this effect and determined whether the brain pharmacokinetics of other drugs are also affected.
Gene_expression (levels) of THC in brain
13) Confidence 0.11 Published 2001 Journal Biochem. Pharmacol. Section Abstract Doc Link 11331071 Disease Relevance 0 Pain Relevance 0.13
Behavioral tests indicated that the CBD-mediated increases in the brain levels of THC, cocaine, and PCP correlated with increased pharmacological responses.
Gene_expression (levels) of THC in brain associated with cocaine
14) Confidence 0.11 Published 2001 Journal Biochem. Pharmacol. Section Abstract Doc Link 11331071 Disease Relevance 0 Pain Relevance 0.49
The binding of [3H]11-OH-delta 9-tetrahydrocannabinol-1, 1-dimethyl-heptyl (THC-DMH), a recently synthesized cannabinoid analog, was characterized in an in vitro brain slice binding assay and compared to that obtained with [3H]CP-55,940, the radiolabeled ligand used originally to characterize cannabinoid binding sites.
Gene_expression (synthesized) of THC-DMH in brain associated with cannabinoid
15) Confidence 0.11 Published 1992 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 1335065 Disease Relevance 0 Pain Relevance 0.13
Administration of THC produced analgesia as evidenced by delay in the tail-flick reaction time to a thermal stimulus.
Gene_expression (produced) of THC in tail associated with tail-flick and analgesia
16) Confidence 0.08 Published 1980 Journal Eur. J. Pharmacol. Section Abstract Doc Link 6258926 Disease Relevance 0.15 Pain Relevance 0.75
The drugs used to treat symptoms of multiple sclerosis (Sativex, contains THC and CBD) failed to change the neuropathological hallmarks of the disease.
Gene_expression (contains) of THC associated with multiple sclerosis and disease
17) Confidence 0.08 Published 2010 Journal Cell Commun Signal Section Body Doc Link PMC2898685 Disease Relevance 0.88 Pain Relevance 0.29
The THC group performed better than CTR (CTR 138.47 ± 25.844 s, THC group 180.82 ± 26.17 s; p = 0.0046, ANOVA, F2,16 = 3.634; Fig. 1C), whereas CBD performed at control level.
Gene_expression (group) of THC
18) Confidence 0.08 Published 2010 Journal Cell Commun Signal Section Body Doc Link PMC2898685 Disease Relevance 0.12 Pain Relevance 0
Both THC and ghrelin significantly increased AMPK activity in the hypothalamus of WT mice (THC: 197±40% of control, ghrelin: 143.2±11% of control, Kruskal-Wallis test: n?
Gene_expression (Both) of THC in hypothalamus
19) Confidence 0.05 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2258435 Disease Relevance 0 Pain Relevance 0.12
2.014, THC vs. control P?
Gene_expression (2.014) of THC
20) Confidence 0.05 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2258435 Disease Relevance 0 Pain Relevance 0.06

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