INT79001

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Context Info
Confidence 0.36
First Reported 1998
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 0.22
Pain Relevance 1.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transmembrane transport (Scn2a1)
Anatomy Link Frequency
brain 2
SCN 2
Scn2a1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Glutamate 45 100.00 Very High Very High Very High
Glutamate receptor 5 100.00 Very High Very High Very High
Neurotransmitter 95 99.52 Very High Very High Very High
nMDA receptor antagonist 1 92.80 High High
tetrodotoxin 1 88.64 High High
excitatory amino acid 3 88.48 High High
nMDA receptor 10 81.12 Quite High
substance P 11 68.72 Quite High
Neuropeptide 36 65.64 Quite High
antagonist 26 62.16 Quite High
Disease Link Frequency Relevance Heat
Ganglion Cysts 6 88.88 High High
Targeted Disruption 10 52.72 Quite High
Hypertension 9 5.00 Very Low Very Low Very Low
Disease 9 5.00 Very Low Very Low Very Low
Sleep Disorders 8 5.00 Very Low Very Low Very Low
Affective Disorder 8 5.00 Very Low Very Low Very Low
Neuroleptic Malignant Syndrome 5 5.00 Very Low Very Low Very Low
Cancer 5 5.00 Very Low Very Low Very Low
Aging 4 5.00 Very Low Very Low Very Low
Sprains And Strains 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the present study, we showed that application of NMDA at circadian time (CT) 12-15 induced significant glutamate release from the SCN region in vitro.
Positive_regulation (induced) of Localization (release) of SCN in SCN associated with glutamate
1) Confidence 0.36 Published 1998 Journal Neurosci. Lett. Section Abstract Doc Link 9853711 Disease Relevance 0 Pain Relevance 0.48
Different types of glutamate receptors were identified and localized in the SCN using in situ hybridization and immunocytochemistry [51].
Positive_regulation (types) of Localization (localized) of SCN associated with glutamate receptor
2) Confidence 0.31 Published 2006 Journal J Circadian Rhythms Section Body Doc Link PMC1402333 Disease Relevance 0.09 Pain Relevance 0.84
Because little SAAS is released from the horizontal SCN brain slice when the attached optic nerves innervating the SCN are stimulated, little SAAS could be a neurochemical messenger of retinohypothalamic tract (RHT) signaling from the eye.
Positive_regulation (stimulated) of Localization (released) of SCN in brain
3) Confidence 0.22 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935382 Disease Relevance 0.13 Pain Relevance 0
Little SAAS release from the SCN slice is low during subjective nighttime [7], coinciding with high SCN sensitivity to little SAAS.
Positive_regulation (low) of Localization (release) of SCN
4) Confidence 0.22 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935382 Disease Relevance 0 Pain Relevance 0.16

General Comments

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