INT7901

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Context Info
Confidence 0.15
First Reported 1992
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 14
Total Number 15
Disease Relevance 1.58
Pain Relevance 8.80

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
nucleus accumbens 2
neuron 1
brain 1
Ppidl1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 35 100.00 Very High Very High Very High
Nucleus accumbens 12 100.00 Very High Very High Very High
dopamine receptor 11 99.84 Very High Very High Very High
Eae 16 99.76 Very High Very High Very High
Desipramine 10 99.58 Very High Very High Very High
isoflurane 6 99.52 Very High Very High Very High
fluoxetine 12 99.32 Very High Very High Very High
monoamine 7 99.08 Very High Very High Very High
lidocaine 10 98.42 Very High Very High Very High
agonist 50 98.12 Very High Very High Very High
Disease Link Frequency Relevance Heat
Overactive Bladder 4 98.72 Very High Very High Very High
Disease 13 93.84 High High
Hypoxia 6 88.88 High High
Sleep Disorders 1 82.24 Quite High
Urological Neuroanatomy 1 81.80 Quite High
Depression 1 76.72 Quite High
Schizophrenia 3 76.32 Quite High
Dyskinesias 2 75.68 Quite High
Parkinson's Disease 3 68.96 Quite High
Pheochromocytoma 1 47.52 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Compared to vaginal birth, D1-like receptors were increased following C-section birth from isoflurane-anesthetized dams, as well as from decapitated dams.
Positive_regulation (increased) of D1-like associated with isoflurane
1) Confidence 0.15 Published 2002 Journal Exp. Neurol. Section Abstract Doc Link 12061868 Disease Relevance 0.19 Pain Relevance 0.32
The current study examined (1) the developmental time course of changes in D1-like or D2-like receptors following C-section birth; (2) whether C-section birth from isoflurane-anesthetized dams also results in altered D1-like receptor levels, as does C-section from decapitated dams; and (3) behavioral responses to D1 and D2 agonists in rats born vaginally compared to C-section.
Positive_regulation (results) of D1-like associated with agonist and isoflurane
2) Confidence 0.15 Published 2002 Journal Exp. Neurol. Section Abstract Doc Link 12061868 Disease Relevance 0.24 Pain Relevance 0.32
Increases in nucleus accumbens D1-like receptor binding due to C-section birth were observed only at adulthood (3 months) but not prepubertally (1 month or 2 weeks).
Positive_regulation (Increases) of D1-like in nucleus accumbens associated with nucleus accumbens
3) Confidence 0.13 Published 2002 Journal Exp. Neurol. Section Abstract Doc Link 12061868 Disease Relevance 0.22 Pain Relevance 0.33
Repeated administration of fluoxetine, desipramine and tranylcypromine increases dopamine D2-like but not D1-like receptor function in the rat.
Positive_regulation (increases) of D1-like associated with dopamine, desipramine and fluoxetine
4) Confidence 0.11 Published 1998 Journal J. Psychopharmacol. (Oxford) Section Title Doc Link 10958251 Disease Relevance 0 Pain Relevance 1.05
Our data suggest that repeated administration of fluoxetine, desipramine and tranylcypromine increases central DA D2-like but not D1-like receptor function.
Positive_regulation (increases) of D1-like associated with dopamine, desipramine and fluoxetine
5) Confidence 0.11 Published 1998 Journal J. Psychopharmacol. (Oxford) Section Abstract Doc Link 10958251 Disease Relevance 0 Pain Relevance 0.99
Chronic treatment with tetrodotoxin reduced the number of fluorescent clusters of both D1-like and D2-like receptors, while chronic treatment with a high concentration of potassium increased the number of fluorescent clusters of both D1-like and D2-like receptors.
Positive_regulation (increased) of D1-like associated with tetrodotoxin
6) Confidence 0.09 Published 2000 Journal Neuroreport Section Abstract Doc Link 10976947 Disease Relevance 0.08 Pain Relevance 0.13
Administration of lidocaine into the DH further potentiated the increase in locomotor activity induced by activation of D1-like receptors or co-activation of D1-like and D2-like receptors in the NAcc core.
Positive_regulation (activation) of D1-like associated with eae and lidocaine
7) Confidence 0.09 Published 2007 Journal Hippocampus Section Abstract Doc Link 17604350 Disease Relevance 0 Pain Relevance 1.02
Administration of lidocaine into the VH also potentiated the increase in locomotor activity induced by D1-like receptor activation, but decreased that produced by co-activation of D1-like and D2-like receptors in the NAcc core.
Positive_regulation (co-activation) of D1-like associated with eae and lidocaine
8) Confidence 0.04 Published 2007 Journal Hippocampus Section Abstract Doc Link 17604350 Disease Relevance 0 Pain Relevance 0.86
The purpose of the present study was to determine whether stimulation of D1-like or D2-like receptors is responsible for this behavioral effect and whether the critical DA receptors are located pre- or postsynaptically.
Spec (whether) Positive_regulation (stimulation) of D1-like
9) Confidence 0.04 Published 1997 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 9335082 Disease Relevance 0 Pain Relevance 0.52
Experiments 1a and 1b tested ethanol-induced activity (0 or 2.5 g/kg) after a D1-like (SCH23390; 0, .015, .030, or .060 mg/kg) or a D2-like (sulpiride; 0, 5, 10, or 20 mg/kg) receptor antagonist, respectively.
Positive_regulation (induced) of D1-like associated with antagonist
10) Confidence 0.03 Published 2010 Journal Dev Psychobiol Section Abstract Doc Link 19842128 Disease Relevance 0.08 Pain Relevance 0.39
These findings indicate a functional role for phospholipase C-coupled D1-like receptors in both modulating synaptic transmission in NAcc and potentiating NMDA receptors on a subset of NAcc neurones, via PKC activation.
Positive_regulation (role) of D1-like in NAcc associated with nucleus accumbens, kinase c and nmda receptor
11) Confidence 0.03 Published 1999 Journal Neuropharmacology Section Abstract Doc Link 10218863 Disease Relevance 0.08 Pain Relevance 0.85
Apomorphine, which stimulates D1-like and D2-like dopamine receptors, induces detrusor overactivity in rats.
Positive_regulation (stimulates) of D1-like associated with tramadol, dopamine receptor and overactive bladder
12) Confidence 0.02 Published 2003 Journal J. Urol. Section Abstract Doc Link 12796703 Disease Relevance 0.37 Pain Relevance 0.57
A remarkable feature of dopamine functioning is that the concomitant activation of D1-like and D2-like receptors acts to intensify the expression of various dopamine-dependent effects, in particular the expression of the immediate-early genes, c-fos and zif268.
Positive_regulation (activation) of D1-like associated with dopamine
13) Confidence 0.02 Published 1999 Journal Eur. J. Neurosci. Section Abstract Doc Link 10103090 Disease Relevance 0 Pain Relevance 0.24
It has been demonstrated that SKF83959 produces no cAMP formation in brain tissues but induces PI-hydrolysis via activation of the PI-linked D1-like receptor/Gq protein/PLC?
Positive_regulation (activation) of D1-like in brain
14) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2948503 Disease Relevance 0.32 Pain Relevance 0.05
These findings suggest that stimulation of dopamine D1-like receptors (or related monoamine receptors) and glutamate NMDA receptors activates neuron-specific programs of immediate-early gene expression in the striatum.
Positive_regulation (stimulation) of D1-like in neuron associated with glutamate, dopamine, nmda receptor and monoamine
15) Confidence 0.01 Published 1992 Journal J. Neurophysiol. Section Abstract Doc Link 1359024 Disease Relevance 0 Pain Relevance 1.16

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