INT79016

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Context Info
Confidence 0.44
First Reported 1998
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 0.59
Pain Relevance 0.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Gstt1) cytoplasm (Gstt1)
Anatomy Link Frequency
skin 1
stomach 1
Gstt1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
melanocortin 1 receptor 8 98.72 Very High Very High Very High
cINOD 4 50.36 Quite High
headache 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 1 98.04 Very High Very High Very High
Skin Cancer 7 94.48 High High
Cutaneous Melanoma 2 83.28 Quite High
Cancer 2 67.68 Quite High
Gastrointestinal Neoplasms 2 51.80 Quite High
INFLAMMATION 2 49.80 Quite Low
Nevus 1 25.52 Quite Low
Headache 1 5.00 Very Low Very Low Very Low
Vomiting 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Gastric rGSTT1-1 protein levels were enhanced by alpha-angelicalactone, alpha-tocopherol, coumarin, ellagic acid, oltipraz, PEITC and the sulphoraphane analogue compound-30.
Gene_expression (levels) of rGSTT1-1
1) Confidence 0.44 Published 1998 Journal Carcinogenesis Section Abstract Doc Link 9855024 Disease Relevance 0.12 Pain Relevance 0.10
In conclusion, dietary anticarcinogens are capable of inducing rGSTT1-1 protein levels in the rat gastrointestinal tract, and are most pronounced in the stomach.
Gene_expression (levels) of rGSTT1-1 in stomach
2) Confidence 0.40 Published 1998 Journal Carcinogenesis Section Abstract Doc Link 9855024 Disease Relevance 0 Pain Relevance 0
Polymorphisms in glutathione-related genes (glutamate cysteine ligase catalytic subunit (GCLC)-129, glutamate cysteine ligase modifier subunit (GCLM)-588, glutathione S-transferase alpha 1 (GSTA1)-52, GSTM1*O, GSTP1-105, GSTP1-114, and GSTT1*O) were analyzed by Taqman-based allelic discrimination and ordinary PCR.
Gene_expression (-588) of GSTT1
3) Confidence 0.24 Published 2008 Journal Int Arch Occup Environ Health Section Body Doc Link 18066575 Disease Relevance 0 Pain Relevance 0
GSTT1 and GSTM1 are enzymes expressed in the skin that detoxify products of oxidative stress reactions caused by UV irradiation.
Gene_expression (expressed) of GSTT1 in skin associated with stress
4) Confidence 0.17 Published 2007 Journal Arch. Dermatol. Res. Section Abstract Doc Link 17072629 Disease Relevance 0.47 Pain Relevance 0.60

General Comments

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