INT79017

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Context Info
Confidence 0.73
First Reported 1998
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 23
Total Number 24
Disease Relevance 13.16
Pain Relevance 0.97

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (GSTT1) cytoplasm (GSTT1)
Anatomy Link Frequency
leukocyte 2
liver 1
GSTT1 (Homo sapiens)
Pain Link Frequency Relevance Heat
carpal tunnel syndrome 2 99.80 Very High Very High Very High
Inflammation 5 94.40 High High
Paracetamol 6 86.56 High High
Chronic pancreatitis 8 85.20 High High
alcohol 25 75.00 Quite High
adenocard 1 65.08 Quite High
cINOD 2 61.52 Quite High
Angina 9 23.80 Low Low
drug abuse 4 10.28 Low Low
Dextromethorphan 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 96 100.00 Very High Very High Very High
Berylliosis 2 100.00 Very High Very High Very High
Coronary Artery Disease 519 99.96 Very High Very High Very High
Carpal Tunnel Syndrome 2 99.80 Very High Very High Very High
Nicotine Addiction 585 99.04 Very High Very High Very High
Hypercholesterolemia 20 98.48 Very High Very High Very High
Diabetes Mellitus 73 96.88 Very High Very High Very High
Hypertension 59 94.80 High High
INFLAMMATION 6 94.40 High High
Obesity 100 94.12 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
66) with the expression level of glutathione S-transferase theta 1, GSTT1) [36].
Gene_expression (expression) of GSTT1
1) Confidence 0.73 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2688030 Disease Relevance 0.21 Pain Relevance 0
66) with the expression level of glutathione S-transferase theta 1, GSTT1) [36].
Gene_expression (expression) of glutathione S-transferase theta 1
2) Confidence 0.73 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2688030 Disease Relevance 0.21 Pain Relevance 0
The scenarios involve glutathione-S-transferase theta 1 (GSTT1) and hematopoietic cancer in hospital workers, human leukocyte antigen coding for glutamic acid in the 69th position (HLA DPB1(E69)) and chronic beryllium disease in beryllium workers, and peripheral myelin protein 22 (PMP22) deletion and carpal tunnel syndrome in railroad track workers.
Gene_expression (deletion) of GSTT1 in leukocyte associated with berylliosis, cancer and carpal tunnel syndrome
3) Confidence 0.67 Published 2004 Journal Scand J Work Environ Health Section Abstract Doc Link 15018031 Disease Relevance 0.30 Pain Relevance 0.10
Considering the synergistic effects of GSTM1 null genotype and GSTT1 null genotype on risk of smoking-related CAD, we found that smokers with both GSTM1 and GSTT1 null genotype were at an approximately 2.76-fold higher risk of CAD than nonsmokers with both GSTM1 and GSTT1 positive genotype (CI, 1.17-6.52, p=0.04)
Gene_expression (genotype) of GSTT1 associated with coronary artery disease and nicotine addiction
4) Confidence 0.67 Published 2008 Journal Journal of Korean Medical Science Section Body Doc Link PMC2526535 Disease Relevance 2.40 Pain Relevance 0
Similarly, GSTT1 gene on chromosome 22q11,2 has two classes denoted as GSTT1-null homozygote for the null allele (GSTT1-0), and GSTT1-1 with at least one functional allele.
Gene_expression (homozygote) of GSTT1-0
5) Confidence 0.67 Published 2008 Journal Journal of Korean Medical Science Section Body Doc Link PMC2526535 Disease Relevance 0.92 Pain Relevance 0.05
We acquired data for GSTM1 gene and GSTT1 gene polymorphisms in 692 subjects (89.3%) due to missing data of gene analysis (missing data [83]: group A [47], B [34], and C [2]).


Gene_expression (gene) of GSTT1
6) Confidence 0.67 Published 2008 Journal Journal of Korean Medical Science Section Body Doc Link PMC2526535 Disease Relevance 0.91 Pain Relevance 0
Similarly, GSTT1 gene on chromosome 22q11,2 has two classes denoted as GSTT1-null homozygote for the null allele (GSTT1-0), and GSTT1-1 with at least one functional allele.
Gene_expression (homozygote) of GSTT1-null
7) Confidence 0.67 Published 2008 Journal Journal of Korean Medical Science Section Body Doc Link PMC2526535 Disease Relevance 0.91 Pain Relevance 0.05
Similarly, GSTT1 gene on chromosome 22q11,2 has two classes denoted as GSTT1-null homozygote for the null allele (GSTT1-0), and GSTT1-1 with at least one functional allele.
Gene_expression (homozygote) of GSTT1-1
8) Confidence 0.67 Published 2008 Journal Journal of Korean Medical Science Section Body Doc Link PMC2526535 Disease Relevance 0.93 Pain Relevance 0.05
Table 3 shows the distribution of NAT2, GSTM1, GSTT1, and GSTP1 genotypes by self-reported chemical-related sensitivity score (?
Gene_expression (distribution) of GSTT1
9) Confidence 0.67 Published 2007 Journal Environ Health Section Body Doc Link PMC1802749 Disease Relevance 0.18 Pain Relevance 0
We therefore investigated whether the anticarcinogens alpha-angelicalactone, alpha-tocopherol, beta-carotene, coumarin, ellagic acid, flavone, indole-3-carbinol, d-limonene, oltipraz, phenethylisothiocyanate (PEITC) and the sulphoraphane analogue compound-30 affect gastrointestinal rGSTT1-1 protein levels in male Wistar rats. rGSTT1-1 protein levels were determined in cytosolic fractions of liver and oesophageal-, gastric-, small intestinal- and colonic mucosa by densitometrical analyses of western blots after immunodetection with an anti human GSTT1-1 monoclonal antibody, that cross-reacts with rGSTT1-1.
Gene_expression (immunodetection) of GSTT1 in liver
10) Confidence 0.65 Published 1998 Journal Carcinogenesis Section Abstract Doc Link 9855024 Disease Relevance 0.20 Pain Relevance 0.12
Absence of GSTM1 or GSTT1 can be attributed to absence of the GSTM1 or GSTT1 gene products (null genotype) in approximately 50% and 20% of the Caucasian population, respectively.
Gene_expression (products) of GSTT1
11) Confidence 0.65 Published 2003 Journal Am. J. Med. Genet. A Section Abstract Doc Link 12794689 Disease Relevance 0.41 Pain Relevance 0.36
Univariate analysis showed that the following variables were associated with the manifestation of CAD: GSTT1 genotype (p < .001), GSTM genotype (p < .001), haplotype GSTT1 plus GSTM1 (p < .001), smoking, age, elevated cholesterol and triglycerides, diabetes mellitus (DM), family history of CAD (FH), hypertension and obesity, whereas gender (p = .1) and myocardial infarction (MI) on admission (p = .067) were not.
Gene_expression (genotype) of GSTT1 associated with nicotine addiction, coronary artery disease, diabetes mellitus, obesity, hypertension, myocardial infarction and hypercholesterolemia
12) Confidence 0.63 Published 2006 Journal BMC Med Genet Section Body Doc Link PMC1458325 Disease Relevance 1.39 Pain Relevance 0
Univariate analysis showed that the following variables were associated with the manifestation of CAD: GSTT1 genotype (p < .001), GSTM genotype (p < .001), haplotype GSTT1 plus GSTM1 (p < .001), smoking, age, elevated cholesterol and triglycerides, diabetes mellitus (DM), family history of CAD (FH), hypertension and obesity, whereas gender (p = .1) and myocardial infarction (MI) on admission (p = .067) were not.
Gene_expression (haplotype) of GSTT1 associated with nicotine addiction, coronary artery disease, diabetes mellitus, obesity, hypertension, myocardial infarction and hypercholesterolemia
13) Confidence 0.63 Published 2006 Journal BMC Med Genet Section Body Doc Link PMC1458325 Disease Relevance 1.39 Pain Relevance 0
Univariate analysis showed that the following variables were associated with the manifestation of CAD: GSTT1 genotype (p < .001), GSTM genotype (p < .001), haplotype GSTT1 plus GSTM1 (p < .001), smoking, age, elevated cholesterol and triglycerides, diabetes mellitus (DM), family history of CAD (FH), hypertension and obesity, whereas gender (p = .1) and myocardial infarction (MI) on admission (p = .067) were not.
Gene_expression (genotype) of GSTT1 associated with nicotine addiction, coronary artery disease, diabetes mellitus, obesity, hypertension, myocardial infarction and hypercholesterolemia
14) Confidence 0.63 Published 2006 Journal BMC Med Genet Section Body Doc Link PMC1458325 Disease Relevance 1.31 Pain Relevance 0
Over half (57) of our study participants were GSTT1 null; 43 were GSTT1 positive (GSTT1 wild type or GSTT1 heterozygous null).
Gene_expression (null) of GSTT1
15) Confidence 0.63 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2199304 Disease Relevance 0 Pain Relevance 0
Therefore, we used the initial GCRC genotyping results to identify potential participants who were GSTT1 positive.
Gene_expression (positive) of GSTT1
16) Confidence 0.63 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2199304 Disease Relevance 0.18 Pain Relevance 0.09
Over half (57) of our study participants were GSTT1 null; 43 were GSTT1 positive (GSTT1 wild type or GSTT1 heterozygous null).
Gene_expression (type) of GSTT1
17) Confidence 0.63 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2199304 Disease Relevance 0 Pain Relevance 0
Over half (57) of our study participants were GSTT1 null; 43 were GSTT1 positive (GSTT1 wild type or GSTT1 heterozygous null).
Gene_expression (positive) of GSTT1
18) Confidence 0.63 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2199304 Disease Relevance 0 Pain Relevance 0
For the differential polymerase chain reaction (PCR) method for GSTT1 genotyping, we used a housekeeping gene (?
Gene_expression (genotyping) of GSTT1
19) Confidence 0.63 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2199304 Disease Relevance 0 Pain Relevance 0
Over half (57) of our study participants were GSTT1 null; 43 were GSTT1 positive (GSTT1 wild type or GSTT1 heterozygous null).
Gene_expression (positive) of GSTT1
20) Confidence 0.63 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2199304 Disease Relevance 0 Pain Relevance 0

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