INT7903

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Context Info
Confidence 0.70
First Reported 1992
Last Reported 2010
Negated 1
Speculated 2
Reported most in Abstract
Documents 21
Total Number 23
Disease Relevance 3.53
Pain Relevance 11.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Fosl1) nucleus (Fosl1) DNA binding (Fosl1)
Anatomy Link Frequency
brain 2
neurons 2
entopeduncular nucleus 1
caudal half 1
medulla 1
Fosl1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cocaine 20 100.00 Very High Very High Very High
antagonist 25 99.98 Very High Very High Very High
adenocard 5 99.90 Very High Very High Very High
agonist 61 99.78 Very High Very High Very High
Dorsal horn 2 99.68 Very High Very High Very High
Dopamine 135 99.60 Very High Very High Very High
Central nervous system 1 99.52 Very High Very High Very High
Glutamate 28 99.44 Very High Very High Very High
withdrawal 19 99.42 Very High Very High Very High
antidepressant 6 99.28 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 13 99.98 Very High Very High Very High
Arthritis 3 98.00 Very High Very High Very High
Temporomandibular Joint Syndrome 5 97.66 Very High Very High Very High
Injury 5 96.94 Very High Very High Very High
Pain 8 96.44 Very High Very High Very High
Hyperalgesia 5 96.40 Very High Very High Very High
Urological Neuroanatomy 13 96.04 Very High Very High Very High
Congenital Anomalies 2 95.52 Very High Very High Very High
Parkinson's Disease 21 93.64 High High
Nociception 4 92.44 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Prolonged increases in Fos-protein-like-immunoreactivity (FOS-LI) are seen in the dorsal horn of adjuvant arthritic rats, and parallel increased pain behavior.
Positive_regulation (increases) of Fos-protein-like-immunoreactivity in dorsal horn associated with pain, dorsal horn and arthritis
1) Confidence 0.70 Published 1995 Journal Neurosci. Lett. Section Abstract Doc Link 7566645 Disease Relevance 0.43 Pain Relevance 0.40
The results showed that following epicardial application of adenosine the Fos-like protein immunoreactive (FLI) neurons were remarkably increased in the dorsal horn of T3 spinal segment, nucleus paragigantocellularis lateralis (PGL) of medulla oblongata, ventral postero-lateral thalamic nucleus (VPL), posterior thalamic nucleus (Po), parafascicular thalamic nucleus (PF) and centrolateral thalamic nucleus (CL), while the blood pressure and heart rate were not affected.
Positive_regulation (increased) of Fos-like protein in blood associated with medulla, adenocard and dorsal horn
2) Confidence 0.59 Published 1997 Journal Sheng Li Xue Bao Section Abstract Doc Link 9812870 Disease Relevance 0 Pain Relevance 0.67
To study the effects of these neurotransmitters on gene transcription in striatal neurons, we treated rats with dopamine (monoamine) agonists and with glutamate agonists and monitored the induction of Fos-like protein in striatal neurons.
Positive_regulation (induction) of Fos-like in neurons associated with glutamate, dopamine, neurotransmitter, agonist and monoamine
3) Confidence 0.58 Published 1992 Journal J. Neurophysiol. Section Abstract Doc Link 1359024 Disease Relevance 0.09 Pain Relevance 1.03
Therefore, the temporal induction of FOS-like protein in rat brain was examined following IP administration of 60 micromol/kg cocaethylene.
Spec (examined) Positive_regulation (induction) of FOS-like in brain
4) Confidence 0.55 Published 1997 Journal Brain Res. Bull. Section Abstract Doc Link 9092881 Disease Relevance 0 Pain Relevance 0.19
Dopaminergic and glutamatergic mechanisms mediate the induction of FOS-like protein by cocaethylene.
Positive_regulation (induction) of FOS-like associated with analgesic
5) Confidence 0.55 Published 1997 Journal Brain Res. Bull. Section Title Doc Link 9092881 Disease Relevance 0 Pain Relevance 0.38
The present study was designed to examine the induction of c-fos mRNA and Fos-like protein in the rostral medulla of awake rats following electroacupuncture (EA) stimulation, using in situ hybridization and immunohistochemical method.
Spec (examine) Positive_regulation (induction) of Fos-like in medulla associated with medulla and electroacupuncture
6) Confidence 0.49 Published 1993 Journal Int. J. Neurosci. Section Abstract Doc Link 8138374 Disease Relevance 0 Pain Relevance 0.39
This absence of changes in cocaine-induced Fos-like proteins might result from a compensatory mechanism between the increase in the dopaminergic response and the decrease in the functional activity of dopamine D(1) receptors.
Positive_regulation (cocaine-induced) of Fos-like associated with dopamine and cocaine
7) Confidence 0.47 Published 2001 Journal Eur. J. Neurosci. Section Abstract Doc Link 11207816 Disease Relevance 0 Pain Relevance 0.71
Functional classification of antidepressants based on antagonism of swim stress-induced fos-like immunoreactivity.
Positive_regulation (induced) of fos-like immunoreactivity associated with stress and antidepressant
8) Confidence 0.47 Published 1996 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 8627519 Disease Relevance 0.27 Pain Relevance 0.43
Glutamate agonist stimulation, but not dopamine agonist stimulation, induced Fos-like protein in a subpopulation of striatal interneurons, namely, a group of neurons exhibiting NADPH-diaphorase activity. 6.
Positive_regulation (induced) of Fos-like in interneurons associated with dopamine, glutamate and agonist
9) Confidence 0.42 Published 1992 Journal J. Neurophysiol. Section Abstract Doc Link 1359024 Disease Relevance 0 Pain Relevance 1.24
The dopamine agonists failed to induce detectable Fos-like protein in striatal neurons expressing enkephalin, even though many such neurons expressed DARPP-32.
Neg (failed) Positive_regulation (induce) of Fos-like in neurons associated with dopamine, agonist and enkephalin
10) Confidence 0.42 Published 1992 Journal J. Neurophysiol. Section Abstract Doc Link 1359024 Disease Relevance 0 Pain Relevance 1.45
In addition, PMA caused the induction of c-fos, c-jun and fra-1 mRNA level and, especially, PMA-induced increase of fra-1 mRNA level was further enhanced by CHX treatment at 4 h.
Positive_regulation (increase) of fra-1
11) Confidence 0.40 Published 1998 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9555062 Disease Relevance 0 Pain Relevance 0
Furthermore, western immunoblot assay showed that PMA caused induction of c-Fos, Fra-1, and c-Jun protein levels.
Positive_regulation (induction) of Fra-1
12) Confidence 0.40 Published 1998 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9555062 Disease Relevance 0 Pain Relevance 0
Animals in late diestrus revealed a more than fivefold increase in the density of Fos-like immunoreactive nuclei in the dorsolateral, lateral, and ventrolateral columns in the caudal half of the periaqueductal gray matter (PAG).
Positive_regulation (increase) of Fos-like in caudal half associated with urological neuroanatomy and central grey
13) Confidence 0.39 Published 2010 Journal Neuropsychopharmacology Section Abstract Doc Link 20072120 Disease Relevance 0.89 Pain Relevance 0.37
Injection of systemic antagonist increased the Fos-like immunoreactivity throughout the first sacral segment, particularly in laminae I/II, X, and in the sacral parasympathetic nucleus (SPN).
Positive_regulation (increased) of Fos-like in SPN associated with antagonist and urological neuroanatomy
14) Confidence 0.34 Published 1997 Journal Brain Res. Section Abstract Doc Link 9037396 Disease Relevance 0.39 Pain Relevance 0.84
Acute injury to the temporomandibular joint (TMJ) region activates neurons in multiple, but spatially discrete, areas of the trigeminal spinal nucleus as seen by an increase in Fos-like immunoreactive neurons (Fos-LI).
Positive_regulation (increase) of Fos-like immunoreactive in temporomandibular joint associated with snapping jaw and injury
15) Confidence 0.32 Published 2002 Journal Pain Section Abstract Doc Link 11932076 Disease Relevance 0.64 Pain Relevance 0.69
Withdrawal studies demonstrated robust induction of several known acute Fras, including c-Fos, FosB, Fra-1, Fra-2, and delta FosB, at 6 hr after naltrexone precipitation of withdrawal in the striatum, nucleus accumbens, and several other brain regions.
Positive_regulation (induction) of Fra-1 in brain associated with nucleus accumbens and withdrawal
16) Confidence 0.29 Published 1996 Journal Mol. Pharmacol. Section Abstract Doc Link 8609891 Disease Relevance 0.06 Pain Relevance 1.01
In addition, PMA caused the induction of c-fos, c-jun and fra-1 mRNA level and, especially, PMA-induced increase of fra-1 mRNA level was further enhanced by CHX treatment at 4 h.
Positive_regulation (induction) of fra-1
17) Confidence 0.27 Published 1998 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9555062 Disease Relevance 0 Pain Relevance 0
ACTH treatment completely blocked the MTZ induction of adrenal c-fos mRNA and the subsequent induction of Fos-like immunoreactivity, whereas MTZ increased PPenk and TH mRNAs nearly 3-fold.
Positive_regulation (induction) of Fos-like
18) Confidence 0.15 Published 1993 Journal Mol. Pharmacol. Section Abstract Doc Link 8102782 Disease Relevance 0.06 Pain Relevance 0.21
While c-Fos, Fra-2 and JunB were increased in response to either stimuli, only Fra-1, c-Jun and JunD were increased by PMA.
Positive_regulation (increased) of Fra-1
19) Confidence 0.15 Published 2000 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 11113530 Disease Relevance 0 Pain Relevance 0.04
In addition to the proENK mRNA level, PGE2 also increased c-Fos (approximately 4.3-fold), Fra-1 ( approximately 3.8 fold), and Fra-2 (approximately 8.2-fold) protein levels at 4 h after drug treatment.
Positive_regulation (increased) of Fra-1 in PGE2
20) Confidence 0.12 Published 1998 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9757037 Disease Relevance 0 Pain Relevance 0.05

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