INT7904

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Context Info
Confidence 0.61
First Reported 1992
Last Reported 2008
Negated 1
Speculated 0
Reported most in Abstract
Documents 5
Total Number 6
Disease Relevance 1.39
Pain Relevance 2.96

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Fosl1) nucleus (Fosl1) DNA binding (Fosl1)
Anatomy Link Frequency
neurons 4
superior colliculus 2
mesothelial cells 2
Fosl1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 22 99.98 Very High Very High Very High
Glutamate receptor 4 99.82 Very High Very High Very High
Dopamine 16 99.60 Very High Very High Very High
monoamine 14 99.10 Very High Very High Very High
Enkephalin 3 98.40 Very High Very High Very High
tetrodotoxin 2 95.44 Very High Very High Very High
cocaine 4 94.64 High High
Glutamate 16 90.96 High High
antagonist 4 87.68 High High
Neurotransmitter 4 76.92 Quite High
Disease Link Frequency Relevance Heat
Mesothelioma 220 99.84 Very High Very High Very High
Apoptosis 24 85.32 High High
Disease 10 74.68 Quite High
Adhesions 2 65.04 Quite High
Malignant Neoplastic Disease 42 58.40 Quite High
Neurofibromatosis 2 6 51.52 Quite High
Cancer 66 38.48 Quite Low
Familial Adenomatous Polyposis 8 6.40 Low Low
Infection 32 5.00 Very Low Very Low Very Low
Metastasis 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Basal increase in c-Fos-like expression in superior colliculus of Royal College of Surgeons dystrophic rats can be abolished by intraocular injection of tetrodotoxin.
Positive_regulation (increase) of Gene_expression (expression) of Fos-like in superior colliculus associated with tetrodotoxin
1) Confidence 0.61 Published 2001 Journal Neuroscience Section Title Doc Link 11744251 Disease Relevance 0 Pain Relevance 0.19
Both the indirect monoamine agonists and the glutamate receptor agonist stimulated rapid nuclear expression of Fos-like protein in specific classes of striatal neurons.
Positive_regulation (stimulated) of Gene_expression (expression) of Fos-like in neurons associated with glutamate receptor, agonist and monoamine
2) Confidence 0.58 Published 1992 Journal J. Neurophysiol. Section Abstract Doc Link 1359024 Disease Relevance 0.07 Pain Relevance 1.31
The dopamine agonists failed to induce detectable Fos-like protein in striatal neurons expressing enkephalin, even though many such neurons expressed DARPP-32.
Neg (failed) Positive_regulation (induce) of Gene_expression (detectable) of Fos-like in neurons associated with dopamine, agonist and enkephalin
3) Confidence 0.39 Published 1992 Journal J. Neurophysiol. Section Abstract Doc Link 1359024 Disease Relevance 0 Pain Relevance 1.45
Furthermore, western immunoblot assay showed that PMA caused induction of c-Fos, Fra-1, and c-Jun protein levels.
Positive_regulation (induction) of Gene_expression (levels) of Fra-1
4) Confidence 0.29 Published 1998 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9555062 Disease Relevance 0 Pain Relevance 0
Ramos-Nino et al. [41] found a high level of AP-1 DNA binding activity and an increased expression of Fra-1 in mesothelioma cell lines.
Positive_regulation (increased) of Gene_expression (expression) of Fra-1 associated with mesothelioma
5) Confidence 0.01 Published 2008 Journal J Carcinog Section Body Doc Link PMC2507706 Disease Relevance 0.72 Pain Relevance 0
In addition, rat mesothelial cells exposed to either asbestos or epidermal growth factor (EGF) showed an increase in Fra-1 expression.
Positive_regulation (increase) of Gene_expression (expression) of Fra-1 in mesothelial cells
6) Confidence 0.01 Published 2008 Journal J Carcinog Section Body Doc Link PMC2507706 Disease Relevance 0.59 Pain Relevance 0

General Comments

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