INT79060

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Context Info
Confidence 0.78
First Reported 1998
Last Reported 2010
Negated 2
Speculated 5
Reported most in Abstract
Documents 116
Total Number 128
Disease Relevance 69.25
Pain Relevance 34.84

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (NOS2) oxidoreductase activity (NOS2) nucleus (NOS2)
intracellular (NOS2) cytoplasm (NOS2)
Anatomy Link Frequency
chondrocytes 10
cartilage 7
THP-1 3
smooth muscle cell 3
hepatocytes 3
NOS2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 1404 100.00 Very High Very High Very High
Osteoarthritis 1209 100.00 Very High Very High Very High
COX2 27 100.00 Very High Very High Very High
Arthritis 165 99.96 Very High Very High Very High
cytokine 515 99.92 Very High Very High Very High
rheumatoid arthritis 389 99.84 Very High Very High Very High
Inflammatory response 206 99.76 Very High Very High Very High
Pain 267 99.60 Very High Very High Very High
opiate 13 99.58 Very High Very High Very High
anesthesia 17 99.48 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 1826 100.00 Very High Very High Very High
Osteoarthritis 1263 100.00 Very High Very High Very High
Arthritis 269 99.96 Very High Very High Very High
Rheumatoid Arthritis 389 99.84 Very High Very High Very High
Nasal Polyps 19 99.84 Very High Very High Very High
Osteogenic Sarcomas 48 99.80 Very High Very High Very High
Ulcers 53 99.64 Very High Very High Very High
Pain 249 99.60 Very High Very High Very High
Dysmenorrhea 20 99.44 Very High Very High Very High
Hepatocellular Cancer 3 99.40 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The expression and distribution of inducible nitric oxide synthase (iNOS) was examined in 12 samples of human temporomandibular joint (TMJ) with internal derangement (ID) and four control specimens.
Spec (examined) Gene_expression (expression) of iNOS in internal associated with snapping jaw
1) Confidence 0.78 Published 2001 Journal Arch. Oral Biol. Section Abstract Doc Link 11163600 Disease Relevance 0.10 Pain Relevance 0.15
OBJECTIVE: To evaluate the in vitro effects of diacerhein, a new drug for the treatment of osteoarthritis (OA), and its active metabolite, rhein, on the production of nitric oxide (NO), prostaglandin (PGE2), cyclooxygenase-2 (COX-2), as well as the production and expression of the inducible nitric oxide synthase (iNOS) in human OA chondrocytes.
Gene_expression (production) of iNOS in chondrocytes associated with osteoarthritis
2) Confidence 0.73 Published 1998 Journal J. Rheumatol. Section Abstract Doc Link 9858439 Disease Relevance 0.37 Pain Relevance 0.24
OBJECTIVE: To evaluate the in vitro effects of diacerhein, a new drug for the treatment of osteoarthritis (OA), and its active metabolite, rhein, on the production of nitric oxide (NO), prostaglandin (PGE2), cyclooxygenase-2 (COX-2), as well as the production and expression of the inducible nitric oxide synthase (iNOS) in human OA chondrocytes.
Gene_expression (expression) of iNOS in chondrocytes associated with osteoarthritis
3) Confidence 0.73 Published 1998 Journal J. Rheumatol. Section Abstract Doc Link 9858439 Disease Relevance 0.37 Pain Relevance 0.24
Endothelial NOS mRNA expression was investigated by in situ hybridization using a human endothelial NOS RNA probe.
Spec (investigated) Gene_expression (expression) of NOS mRNA
4) Confidence 0.72 Published 2000 Journal Reprod. Fertil. Dev. Section Abstract Doc Link 11451019 Disease Relevance 0.33 Pain Relevance 0.33
In conclusion, the endothelial NOS mRNA expression seen in the ectopic endometrium suggests a possible relationship with the various pathologies associated with adenomyosis.
Gene_expression (expression) of NOS mRNA in endometrium associated with dismenorea
5) Confidence 0.72 Published 2000 Journal Reprod. Fertil. Dev. Section Abstract Doc Link 11451019 Disease Relevance 0.43 Pain Relevance 0.43
It is noteworthy that the expression of endothelial NOS mRNA was moderately positive in ectopic endometrial tissues in three of the six cases of adenomyosis.
Gene_expression (expression) of NOS mRNA associated with dismenorea
6) Confidence 0.72 Published 2000 Journal Reprod. Fertil. Dev. Section Abstract Doc Link 11451019 Disease Relevance 0.35 Pain Relevance 0.43
Specific expression of endothelial NOS mRNA was found in glandular and surface epithelial cells in eutopic endometrium throughout the menstrual cycle in all groups.
Gene_expression (expression) of NOS mRNA in endometrium
7) Confidence 0.72 Published 2000 Journal Reprod. Fertil. Dev. Section Abstract Doc Link 11451019 Disease Relevance 0.34 Pain Relevance 0.41
The expression and distribution of inducible nitric oxide synthase (iNOS) was examined in 12 samples of human temporomandibular joint (TMJ) with internal derangement (ID) and four control specimens.
Spec (examined) Gene_expression (expression) of inducible nitric oxide synthase in internal associated with snapping jaw
8) Confidence 0.68 Published 2001 Journal Arch. Oral Biol. Section Abstract Doc Link 11163600 Disease Relevance 0.10 Pain Relevance 0.15
This original report that iNOS is expressed in the synovial tissue of the temporomandibular joint indicates that nitric oxide is produced locally at least in the synovial lining in these joints when affected by internal derangement.
Gene_expression (expressed) of iNOS in temporomandibular joint associated with snapping jaw
9) Confidence 0.68 Published 2001 Journal Arch. Oral Biol. Section Abstract Doc Link 11163600 Disease Relevance 0.18 Pain Relevance 0.18
RESULTS: Preincubation of the tissue with morphine, anandamide or estrogen prior to, but not after, the addition of LPS + IFN-gamma, blocked iNOS expression.
Gene_expression (expression) of iNOS
10) Confidence 0.67 Published 2000 Journal Acta Pharmacol. Sin. Section Body Doc Link 11324436 Disease Relevance 0 Pain Relevance 0
Endomorphin 1 activates nitric oxide synthase 2 activity and downregulates nitric oxide synthase 2 mRNA expression.
Gene_expression (expression) of nitric oxide synthase 2
11) Confidence 0.67 Published 2007 Journal Neuroscience Section Title Doc Link 17197099 Disease Relevance 0.08 Pain Relevance 0.28
These findings indicate that sustained overproduction of cytokine and NO via iNOS expression may be responsible, at least in part, for some neurochemical changes in the locus coeruleus caused by chronic opiate usage in humans.
Gene_expression (expression) of iNOS in locus coeruleus associated with locus ceruleus, opiate and cytokine
12) Confidence 0.67 Published 2009 Journal J. Chem. Neuroanat. Section Abstract Doc Link 19038328 Disease Relevance 0.30 Pain Relevance 0.63
However, in the brain of opiate addicts, NADPHd and iNOS expression was detected in noradrenergic LC cells, correlating with an increase in iNOS and TNF-alpha expression in glial cells as revealed by immunohistochemical and Western blot analyses.
Gene_expression (expression) of iNOS in glial cells associated with locus ceruleus and opiate
13) Confidence 0.67 Published 2009 Journal J. Chem. Neuroanat. Section Abstract Doc Link 19038328 Disease Relevance 0.35 Pain Relevance 0.63
OBJECTIVE: To evaluate the in vitro effects of diacerhein, a new drug for the treatment of osteoarthritis (OA), and its active metabolite, rhein, on the production of nitric oxide (NO), prostaglandin (PGE2), cyclooxygenase-2 (COX-2), as well as the production and expression of the inducible nitric oxide synthase (iNOS) in human OA chondrocytes.
Gene_expression (production) of iNOS in chondrocytes associated with osteoarthritis
14) Confidence 0.63 Published 1998 Journal J. Rheumatol. Section Abstract Doc Link 9858439 Disease Relevance 0.37 Pain Relevance 0.24
Pretreatment of BV-2 cells with GLNVA diminished LPS-induced nitric oxide production, overexpression of inducible nitric-oxide synthase (iNOS), and gp91(phox) and intracellular reactive oxygen species (iROS).
Gene_expression (production) of inducible nitric-oxide synthase
15) Confidence 0.62 Published 2007 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 17855475 Disease Relevance 0.92 Pain Relevance 0.20
Pretreatment of BV-2 cells with GLNVA diminished LPS-induced nitric oxide production, overexpression of inducible nitric-oxide synthase (iNOS), and gp91(phox) and intracellular reactive oxygen species (iROS).
Gene_expression (production) of iNOS
16) Confidence 0.62 Published 2007 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 17855475 Disease Relevance 0.93 Pain Relevance 0.20
GLNVA also suppressed accumulation of iROS and up-regulated heme oxygenase-1 expression. 6-OHDA-induced overexpression of nNOS, iNOS, COX-2, and gp91(phox) was also reduced by GLNVA.
Gene_expression (overexpression) of iNOS
17) Confidence 0.62 Published 2007 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 17855475 Disease Relevance 0.64 Pain Relevance 0.16
Expression of endothelial nitric-oxide synthase (eNOS) and inducible nitric-oxide synthase (iNOS) were analyzed by reverse transcriptase-polymerase chain reaction.
Spec (analyzed) Gene_expression (Expression) of iNOS
18) Confidence 0.59 Published 2006 Journal Inflamm. Res. Section Body Doc Link 17122960 Disease Relevance 0 Pain Relevance 0
The inducible NOS isoform (iNOS) is capable of producing NO at high concentrations which have pro-inflammatory properties.
Neg (NO) Gene_expression (producing) of iNOS associated with inflammation
19) Confidence 0.56 Published 2000 Journal Hum. Reprod. Section Abstract Doc Link 11041226 Disease Relevance 0.19 Pain Relevance 0.10
Although previous work has provided evidence in rheumatoid arthritis (RA) for increased production of systemic NO [14-21] and increased expression of inducible NO synthase (NOS2) and production of NO [22], most studies of urine and serum NOx levels have been performed in patients eating a normal diet [17] or after only an overnight fast [15].
Gene_expression (expression) of NOS2 in urine associated with rheumatoid arthritis
20) Confidence 0.53 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1779437 Disease Relevance 0.62 Pain Relevance 0.24

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