INT79061

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.65
First Reported 1998
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 92
Total Number 92
Disease Relevance 58.89
Pain Relevance 23.96

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (NOS2) oxidoreductase activity (NOS2) nucleus (NOS2)
intracellular (NOS2) cytoplasm (NOS2)
Anatomy Link Frequency
macrophages 4
chondrocytes 3
lung 3
TMJ 3
neuronal 3
NOS2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Osteoarthritis 422 100.00 Very High Very High Very High
Inflammation 913 99.84 Very High Very High Very High
Inflammatory response 162 99.64 Very High Very High Very High
Arthritis 81 99.62 Very High Very High Very High
cytokine 433 99.60 Very High Very High Very High
Angina 14 99.52 Very High Very High Very High
Locus ceruleus 5 99.44 Very High Very High Very High
Abeta 23 99.42 Very High Very High Very High
Clonidine 10 99.42 Very High Very High Very High
agonist 188 99.40 Very High Very High Very High
Disease Link Frequency Relevance Heat
Osteoarthritis 446 100.00 Very High Very High Very High
Infection 73 99.98 Very High Very High Very High
Lung Injury 81 99.96 Very High Very High Very High
Increased Venous Pressure Under Development 221 99.92 Very High Very High Very High
Adult Respiratory Distress Syndrome 139 99.92 Very High Very High Very High
Endotoxemia 18 99.86 Very High Very High Very High
INFLAMMATION 1174 99.84 Very High Very High Very High
Osteogenic Sarcomas 48 99.80 Very High Very High Very High
Arthritis 124 99.62 Very High Very High Very High
Atherosclerotic Plaque 15 99.62 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
OBJECTIVE: To evaluate the in vitro effects of diacerhein, a new drug for the treatment of osteoarthritis (OA), and its active metabolite, rhein, on the production of nitric oxide (NO), prostaglandin (PGE2), cyclooxygenase-2 (COX-2), as well as the production and expression of the inducible nitric oxide synthase (iNOS) in human OA chondrocytes.
Positive_regulation (inducible) of iNOS in chondrocytes associated with osteoarthritis
1) Confidence 0.65 Published 1998 Journal J. Rheumatol. Section Abstract Doc Link 9858439 Disease Relevance 0.37 Pain Relevance 0.24
Moreover, accumulation of a marker of protein nitration nitrotyrosine, as well as the superoxide anion (O(2)(-)) levels and inducible nitric oxide synthase (iNOS), were evaluated.
Positive_regulation (inducible) of iNOS
2) Confidence 0.65 Published 2004 Journal Diabetes Section Abstract Doc Link 15331549 Disease Relevance 1.23 Pain Relevance 0.35
With respect to the current literature and the clinical findings it is discussed that both increased leukocyte/endothelial cell adhesion and altered release of reactive oxygen species or inducible nitric oxide synthase (iNOS) may play a role in 5-FU-induced colitis.
Positive_regulation (inducible) of iNOS in endothelial cell
3) Confidence 0.62 Published 2007 Journal Strahlenther Onkol Section Body Doc Link 17680227 Disease Relevance 0.08 Pain Relevance 0
Nitrite was quantified as a measure for inducible nitric oxide synthase (iNOS) activity.
Positive_regulation (inducible) of iNOS
4) Confidence 0.59 Published 2004 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 15076232 Disease Relevance 0.47 Pain Relevance 0.54
Propofol also reduced the LPS-enhanced iNOS mRNA and NF-kappaB protein levels whilst it increased eNOS mRNA expression (P < 0.05).
Positive_regulation (enhanced) of iNOS
5) Confidence 0.53 Published 2006 Journal Inflamm. Res. Section Body Doc Link 17122960 Disease Relevance 0 Pain Relevance 0
Indomethacin, ibuprofen, sulindac sulfide, and meloxicam concentration-dependently reduced nitrite production by macrophages incubated with platelets, but did not alter LPS-induced iNOS activity or platelet uptake.
Positive_regulation (induced) of iNOS in platelet
6) Confidence 0.51 Published 2004 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 15076232 Disease Relevance 0.43 Pain Relevance 0.54
The expression and distribution of inducible nitric oxide synthase (iNOS) was examined in 12 samples of human temporomandibular joint (TMJ) with internal derangement (ID) and four control specimens.
Positive_regulation (inducible) of iNOS in internal associated with snapping jaw
7) Confidence 0.50 Published 2001 Journal Arch. Oral Biol. Section Abstract Doc Link 11163600 Disease Relevance 0.10 Pain Relevance 0.15
RESULTS: Exposure of TMJ fibrochondrocytes to rHuIL-1beta resulted in the induction of inducible nitric oxide synthase (iNOS) and cyclooxygenase 2 (COX-2), which were paralleled by NO and PGE2 production.
Positive_regulation (inducible) of iNOS in TMJ
8) Confidence 0.47 Published 2001 Journal Arthritis Rheum. Section Body Doc Link 11263775 Disease Relevance 0 Pain Relevance 0
RESULTS: Exposure of TMJ fibrochondrocytes to rHuIL-1beta resulted in the induction of inducible nitric oxide synthase (iNOS) and cyclooxygenase 2 (COX-2), which were paralleled by NO and PGE2 production.
Positive_regulation (induction) of iNOS in TMJ
9) Confidence 0.47 Published 2001 Journal Arthritis Rheum. Section Body Doc Link 11263775 Disease Relevance 0 Pain Relevance 0
Moreover, accumulation of a marker of protein nitration nitrotyrosine, as well as the superoxide anion (O(2)(-)) levels and inducible nitric oxide synthase (iNOS), were evaluated.
Positive_regulation (accumulation) of iNOS
10) Confidence 0.47 Published 2004 Journal Diabetes Section Abstract Doc Link 15331549 Disease Relevance 1.26 Pain Relevance 0.36
LPS also significantly increased mRNA of iNOS, protein level of NF-kappaB and decreased mRNA of eNOS (P < 0.05).
Positive_regulation (increased) of iNOS
11) Confidence 0.46 Published 2006 Journal Inflamm. Res. Section Body Doc Link 17122960 Disease Relevance 0 Pain Relevance 0
These also activate signaling molecules involved in inflammation and carcinogenesis such as nuclear transcription factor (NF-kappaB), inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2).
Positive_regulation (inducible) of iNOS associated with inflammation
12) Confidence 0.46 Published 2005 Journal Mutat. Res. Section Abstract Doc Link 16083916 Disease Relevance 1.02 Pain Relevance 0.40
-AR stimulation and that ERK phosphorylation precedes transcriptional induction of COX-2 or iNOS.


Positive_regulation (induction) of iNOS
13) Confidence 0.45 Published 2005 Journal Cell Commun Signal Section Body Doc Link PMC1198236 Disease Relevance 0.17 Pain Relevance 0.09
Immunohistochemical localization of inducible nitric oxide synthase in synovial tissue of human temporomandibular joints with internal derangement.
Positive_regulation (inducible) of inducible nitric oxide synthase in temporomandibular joints
14) Confidence 0.44 Published 2001 Journal Arch. Oral Biol. Section Title Doc Link 11163600 Disease Relevance 0.09 Pain Relevance 0.16
The expression and distribution of inducible nitric oxide synthase (iNOS) was examined in 12 samples of human temporomandibular joint (TMJ) with internal derangement (ID) and four control specimens.
Positive_regulation (inducible) of inducible nitric oxide synthase in internal associated with snapping jaw
15) Confidence 0.44 Published 2001 Journal Arch. Oral Biol. Section Abstract Doc Link 11163600 Disease Relevance 0.10 Pain Relevance 0.15
As compared with nondiabetic specimens, diabetic specimens showed higher levels of both iNOS mRNA and protein levels (P < 0.001) associated with the highest tissue levels of nitrotyrosine and O(2)(-) (P < 0.001).
Positive_regulation (levels) of iNOS associated with diabetes mellitus
16) Confidence 0.43 Published 2004 Journal Diabetes Section Abstract Doc Link 15331549 Disease Relevance 1.22 Pain Relevance 0.34
AIM: To determine whether inducible nitric oxide synthase (iNOS) stimulation of human atrial fragments can be diminished by the naturally occurring signal molecules, such as morphine, anandamide, and estrogen.
Positive_regulation (inducible) of iNOS associated with morphine
17) Confidence 0.43 Published 2000 Journal Acta Pharmacol. Sin. Section Abstract Doc Link 11324436 Disease Relevance 0 Pain Relevance 0.17
AIM: To determine whether inducible nitric oxide synthase (iNOS) stimulation of human atrial fragments can be diminished by the naturally occurring signal molecules, such as morphine, anandamide, and estrogen.
Positive_regulation (inducible) of inducible nitric oxide synthase associated with morphine
18) Confidence 0.43 Published 2000 Journal Acta Pharmacol. Sin. Section Abstract Doc Link 11324436 Disease Relevance 0 Pain Relevance 0.17
The nitric oxide donor SNAP also blocked iNOS induction while preincubation of atrial fragments with an inhibitor of NOS, L-NAME, prior to morphine or anandamide exposure, restored LPS + IFN-gamma induction of iNOS.
Positive_regulation (induction) of iNOS
19) Confidence 0.43 Published 2000 Journal Acta Pharmacol. Sin. Section Body Doc Link 11324436 Disease Relevance 0 Pain Relevance 0
On the other hand, using real-time amperometric detection of nitric oxide release shortly after challenge with endomorphins, we showed that only 10(-6) M endomorphin 1 was able to stimulate nitric oxide release from a J774 macrophage cell line by activation of NOS 2 isoenzyme.
Positive_regulation (activation) of NOS 2 isoenzyme in macrophage
20) Confidence 0.43 Published 2007 Journal Neuroscience Section Abstract Doc Link 17197099 Disease Relevance 0.08 Pain Relevance 0.19

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox