INT79062

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Context Info
Confidence 0.14
First Reported 1998
Last Reported 2011
Negated 5
Speculated 1
Reported most in Body
Documents 42
Total Number 43
Disease Relevance 18.89
Pain Relevance 6.98

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (B4GALNT1) plasma membrane (B4GALNT1) carbohydrate metabolic process (B4GALNT1)
Anatomy Link Frequency
chondrocytes 3
macrophages 2
monocytes 2
epithelial cell 2
Endothelial cells 2
B4GALNT1 (Homo sapiens)
Pain Link Frequency Relevance Heat
COX2 12 100.00 Very High Very High Very High
Dismenorea 57 99.92 Very High Very High Very High
Osteoarthritis 55 99.76 Very High Very High Very High
Kinase C 23 99.04 Very High Very High Very High
Inflammation 287 98.96 Very High Very High Very High
Inflammatory response 16 98.80 Very High Very High Very High
electroacupuncture 3 98.60 Very High Very High Very High
Abeta 5 97.66 Very High Very High Very High
agonist 58 97.52 Very High Very High Very High
Inflammatory mediators 56 97.12 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cancer 89 100.00 Very High Very High Very High
Necrosis 33 100.00 Very High Very High Very High
Endometriosis 66 99.92 Very High Very High Very High
Osteoarthritis 57 99.76 Very High Very High Very High
Apoptosis 184 99.24 Very High Very High Very High
Atherosclerosis 129 98.98 Very High Very High Very High
INFLAMMATION 381 98.96 Very High Very High Very High
Atherosclerotic Plaque 9 98.94 Very High Very High Very High
Hypertension 103 98.72 Very High Very High Very High
Stress 1353 98.36 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Cyclooxygenase-2 (COX-2), inducible NO synthase (iNOS) and IL-1beta gene expressions were quantified by transcription of mRNA followed by real time and quantitative polymerase chain reaction.
Gene_expression (expressions) of NO synthase
1) Confidence 0.14 Published 2002 Journal Osteoarthr. Cartil. Section Body Doc Link 12127835 Disease Relevance 0.08 Pain Relevance 0
Inducible NO synthase (iNOS) is present in mononuclear phagocytes (monocytes and macrophages) and produces a large amount of NO.
Gene_expression (present) of synthase in monocytes
2) Confidence 0.10 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1215514 Disease Relevance 0.55 Pain Relevance 0.14
As a final immune effector, NO generated by inducible NO synthase, kills pathogens and abnormal cells but may play a detrimental role by damaging normal host tissue and cells, especially when inducible NO synthase is persistently expressed [20].

2.8 Nitric oxide synthase and fallopian tubes

Neg (NO) Gene_expression (expressed) of synthase in fallopian tubes
3) Confidence 0.10 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1215514 Disease Relevance 0 Pain Relevance 0
In most organs, inducible NO synthase is expressed only in response to immunological stimuli [29].

1.4 Antioxidants

Gene_expression (expressed) of synthase
4) Confidence 0.10 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1215514 Disease Relevance 0.22 Pain Relevance 0.09
Expression of endothelial and inducible NO synthase have been demonstrated in the human endometrium [115], and the endometrial vessels [116].
Gene_expression (Expression) of synthase in endometrium
5) Confidence 0.10 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1215514 Disease Relevance 0.36 Pain Relevance 0
Expressions of endothelial and inducible NO synthase and peroxynitrite generation was markedly reduced after GnRH agonist therapy, supporting their potential role in the pathophysiology of adenomyosis [132].
Gene_expression (Expressions) of synthase associated with dismenorea and agonist
6) Confidence 0.10 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1215514 Disease Relevance 0.93 Pain Relevance 0.56
The presence of NO in the follicular fluid and the expression of NO synthase in follicles and corpus luteum have been reported [19,141,143,145].
Gene_expression (expression) of synthase in corpus luteum
7) Confidence 0.10 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1215514 Disease Relevance 0.90 Pain Relevance 0.03
Inducible NO synthase (iNOS) is present in mononuclear phagocytes (monocytes and macrophages) and produces a large amount of NO.
Neg (NO) Gene_expression (produces) of synthase in monocytes
8) Confidence 0.08 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1215514 Disease Relevance 0.55 Pain Relevance 0.15
NO is produced by the enzyme NO synthase.
Neg (NO) Gene_expression (produced) of synthase
9) Confidence 0.08 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1215514 Disease Relevance 0.68 Pain Relevance 0.13
OBJECTIVE: To evaluate the in vitro effects of diacerhein, a new drug for the treatment of osteoarthritis (OA), and its active metabolite, rhein, on the production of nitric oxide (NO), prostaglandin (PGE2), cyclooxygenase-2 (COX-2), as well as the production and expression of the inducible nitric oxide synthase (iNOS) in human OA chondrocytes.
Gene_expression (production) of synthase in chondrocytes associated with osteoarthritis
10) Confidence 0.07 Published 1998 Journal J. Rheumatol. Section Abstract Doc Link 9858439 Disease Relevance 0.37 Pain Relevance 0.24
Specifically, electroacupuncture (EA) seems to prevent the reduction in NO production from endothelial NO synthetase (eNOS) and neuronal NO synthase (nNOS) that is associated with hypertension and this process involves a stomach-meridian organ but not a non-stomach-meridian organ such as the liver.
Neg (NO) Gene_expression (synthetase) of synthase in liver associated with hypertension and electroacupuncture
11) Confidence 0.06 Published 2008 Journal J Acupunct Meridian Stud Section Abstract Doc Link 20633454 Disease Relevance 0.23 Pain Relevance 0.75
Activation of the cGMP-pathway by sodium nitroprusside or its inhibition by guanylate cyclase (LY83583) or kinase (KT5823) inhibitors had more effects on fundus SMC, on which a higher expression of endothelial nitric oxide synthase was found.
Gene_expression (expression) of synthase in SMC
12) Confidence 0.06 Published 2006 Journal Neurogastroenterol. Motil. Section Abstract Doc Link 17040412 Disease Relevance 0.08 Pain Relevance 0.11
Endothelial cells continuously release nitric oxide (NO), which is synthesized by the endothelial isoform of NO synthase (NOS-III) (Moncada et al 1991; Förstermann et al 1993).
Gene_expression (synthesized) of NO synthase in Endothelial cells
13) Confidence 0.06 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2663454 Disease Relevance 0.37 Pain Relevance 0.14
OBJECTIVE: To evaluate the in vitro effects of diacerhein, a new drug for the treatment of osteoarthritis (OA), and its active metabolite, rhein, on the production of nitric oxide (NO), prostaglandin (PGE2), cyclooxygenase-2 (COX-2), as well as the production and expression of the inducible nitric oxide synthase (iNOS) in human OA chondrocytes.
Gene_expression (expression) of synthase in chondrocytes associated with osteoarthritis
14) Confidence 0.05 Published 1998 Journal J. Rheumatol. Section Abstract Doc Link 9858439 Disease Relevance 0.37 Pain Relevance 0.24
Recent studies show that amyloid beta (Abeta), a peptide extensively studied in Alzheimer's disease and that is cleaved from APP by beta- and gamma-secretase, and/or Abeta-like peptides are also present in human atherosclerotic plaques, in particular in activated, inducible nitric oxide synthase (iNOS) expressing perivascular macrophages that had phagocytized platelets.
Gene_expression (expressing) of synthase in plaques associated with atherosclerotic plaque, alzheimer's dementia, disease and abeta
15) Confidence 0.04 Published 2006 Journal Cardiovascular & hematological disorders drug targets Section Abstract Doc Link 16724933 Disease Relevance 0.98 Pain Relevance 0.38
We have recently demonstrated that human follicular dendritic cells (FDCs) strongly express prostacyclin synthase.
Gene_expression (express) of synthase in follicular dendritic cells
16) Confidence 0.04 Published 2007 Journal Mol. Immunol. Section Abstract Doc Link 17337058 Disease Relevance 0.22 Pain Relevance 0.08
The presence of NO in the follicular fluid and the expression of NO synthase in follicles and corpus luteum have been reported [19,141,143,145].
Gene_expression (expression) of synthase in follicles
17) Confidence 0.03 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1215514 Disease Relevance 0.90 Pain Relevance 0.03
Inducible NO synthase (iNOS) is present in mononuclear phagocytes (monocytes and macrophages) and produces a large amount of NO.
Gene_expression (present) of synthase in macrophages
18) Confidence 0.03 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1215514 Disease Relevance 0.55 Pain Relevance 0.14
In contrast, the effect of lead on NO does not involve decreased NO synthase expression (Vaziri 2002).
Gene_expression (expression) of NO synthase
19) Confidence 0.03 Published 2005 Journal Environ Health Perspect Section Body Doc Link PMC1253707 Disease Relevance 0.11 Pain Relevance 0.05
In fact, just the opposite occurs because lead exposure generates oxidants that deplete NO, and NO synthase expression is up-regulated in response.


Gene_expression (expression) of NO synthase
20) Confidence 0.03 Published 2005 Journal Environ Health Perspect Section Body Doc Link PMC1253707 Disease Relevance 0.05 Pain Relevance 0.04

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