INT79080

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Context Info
Confidence 0.44
First Reported 1999
Last Reported 2008
Negated 1
Speculated 0
Reported most in Title
Documents 4
Total Number 4
Disease Relevance 0.08
Pain Relevance 2.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Htr1a) signal transducer activity (Htr1a)
Anatomy Link Frequency
neuronal 2
hypothalamus 2
brain 2
Htr1a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Paracetamol 7 100.00 Very High Very High Very High
antidepressant 3 100.00 Very High Very High Very High
fluoxetine 18 98.60 Very High Very High Very High
agonist 4 97.40 Very High Very High Very High
Antinociceptive 2 97.36 Very High Very High Very High
antinociception 3 96.48 Very High Very High Very High
noradrenaline 2 95.92 Very High Very High Very High
Serotonin 2 95.20 Very High Very High Very High
Somatostatin 1 93.68 High High
lidocaine 1 83.08 Quite High
Disease Link Frequency Relevance Heat
Pain 1 79.96 Quite High
Nociception 2 49.36 Quite Low
Anxiety Disorder 2 46.48 Quite Low
Depression 1 5.00 Very Low Very Low Very Low
Stress 1 5.00 Very Low Very Low Very Low
Amnesia 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Because hypothalamic Gz proteins mediate the ACTH and oxytocin responses to 5-HT1A receptor activation, we also determined the effect of fluoxetine on the levels of Gz proteins in the hypothalamus.
Regulation (responses) of Positive_regulation (activation) of 5-HT1A in hypothalamus associated with fluoxetine
1) Confidence 0.44 Published 1999 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9862759 Disease Relevance 0 Pain Relevance 0.64
Activation and desensitization by cyclic antidepressant drugs of alpha2-autoreceptors, alpha2-heteroreceptors and 5-HT1A-autoreceptors regulating monamine synthesis in the rat brain in vivo.
Regulation (regulating) of Positive_regulation (Activation) of 5-HT1A in brain associated with antidepressant
2) Confidence 0.44 Published 1999 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Title Doc Link 10494882 Disease Relevance 0 Pain Relevance 0.59
Activation of septal 5-HT1A receptors alters spatial memory encoding, interferes with consolidation, but does not affect retrieval in rats subjected to a water-maze task.
Neg (not) Regulation (affect) of Positive_regulation (Activation) of 5-HT1A
3) Confidence 0.44 Published 2008 Journal Hippocampus Section Title Doc Link 17924524 Disease Relevance 0 Pain Relevance 0.15
Indeed, down-regulation of sst3R mRNA depends on acetaminophen-elicited, 5-HT1A receptor-dependent increase in neuronal extracellular signal-regulated kinase 1/2 (ERK1/2) activities that mediate antinociception.
Regulation (depends) of Positive_regulation (increase) of 5-HT1A in neuronal associated with antinociception and paracetamol
4) Confidence 0.26 Published 2007 Journal Mol. Pharmacol. Section Abstract Doc Link 17088403 Disease Relevance 0.08 Pain Relevance 1.17

General Comments

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