INT7909

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Context Info
Confidence 0.49
First Reported 1985
Last Reported 2010
Negated 2
Speculated 2
Reported most in Abstract
Documents 8
Total Number 10
Disease Relevance 6.44
Pain Relevance 3.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Got1) biosynthetic process (Got1) cellular amino acid metabolic process (Got1)
lysosome (Got1) cytoplasm (Got1)
Anatomy Link Frequency
macrophage 2
liver 2
leucocyte 2
platelet 2
Got1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Paracetamol 36 99.98 Very High Very High Very High
Inflammation 5 99.98 Very High Very High Very High
methadone 4 99.54 Very High Very High Very High
abdominal pain 2 99.28 Very High Very High Very High
Arthritis 3 98.28 Very High Very High Very High
halothane 12 97.42 Very High Very High Very High
anesthesia 2 91.28 High High
Analgesic 5 89.36 High High
aspirin 1 84.56 Quite High
bradykinin 1 82.84 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 7 99.98 Very High Very High Very High
Hepatic Encephalopathy 1 99.96 Very High Very High Very High
Liver Disease 4 99.90 Very High Very High Very High
Necrosis 7 99.74 Very High Very High Very High
Jaundice 2 99.48 Very High Very High Very High
Hypoxia 6 99.40 Very High Very High Very High
Abdominal Pain 2 99.28 Very High Very High Very High
Renal Failure 1 99.08 Very High Very High Very High
Vomiting 4 98.96 Very High Very High Very High
Experimental Arthritis 1 98.28 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Oleanolic acid checked the inflammation-induced increased serum transaminase levels.
Positive_regulation (increased) of Positive_regulation (increased) of serum transaminase associated with inflammation
1) Confidence 0.49 Published 1992 Journal J. Pharm. Pharmacol. Section Abstract Doc Link 1359067 Disease Relevance 0.81 Pain Relevance 0.27
Hepatocytolysis was determined by measuring the level of serum transaminases (GPT and GOT), steatosis by Sudan black staining, histological structures by hamatoxylineosin staining and the activity of enzymes such as SDH, GtDH, G-6-Pase and ATPase.
Spec (determined) Positive_regulation (measuring) of Positive_regulation (level) of GOT
2) Confidence 0.49 Published 1999 Journal Phytother Res Section Abstract Doc Link 10190184 Disease Relevance 0.08 Pain Relevance 0.17
In the halothane group, marked centrilobular necrosis and elevation of SGPT activity were observed; neither significant histological lesions nor elevation of transaminase activity occurred in the highly hypoxic group.
Neg (neither) Positive_regulation (occurred) of Neg (neither) Positive_regulation (elevation) of transaminase associated with necrosis, hypoxia and halothane
3) Confidence 0.42 Published 1985 Journal Hepatology Section Abstract Doc Link 3979956 Disease Relevance 0.67 Pain Relevance 0.67
Pretreatment of the rats with either dextran sulfate or gadolinium chloride, two inhibitors of hepatic macrophage functioning, completely blocked hepatic necrosis, as well as increases in serum transaminase levels induced by acetaminophen.
Positive_regulation (increases) of Positive_regulation (induced) of serum transaminase in macrophage associated with necrosis and paracetamol
4) Confidence 0.41 Published 1995 Journal Hepatology Section Abstract Doc Link 7705777 Disease Relevance 0.88 Pain Relevance 0.89
Treatment with methadone or naltrexone did not result in a transaminase increase in these patients.
Neg (not) Positive_regulation (result) of Positive_regulation (increase) of transaminase associated with methadone
5) Confidence 0.38 Published 1997 Journal Rev Clin Esp Section Abstract Doc Link 9411543 Disease Relevance 0.59 Pain Relevance 0.36
During the last three months of pregnancy and in the immediate post partum period a large number of liver diseases can cause elevated transaminase levels, depending upon the clinical presentation.
Positive_regulation (cause) of Positive_regulation (elevated) of transaminase in liver associated with liver disease
6) Confidence 0.14 Published 1994 Journal Presse Med Section Abstract Doc Link 8022721 Disease Relevance 0.70 Pain Relevance 0.14
The most significant clinical findings are nausea or vomiting, abdominal pain, jaundice, hepatic encephalopathy, increased transaminase levels, decreased platelet count, increased prothrombin time, and renal failure.
Positive_regulation (increased) of Positive_regulation (increased) of transaminase in platelet associated with abdominal pain, renal failure, hepatic encephalopathy, vomiting and jaundice
7) Confidence 0.11 Published 1993 Journal Gastroenterologist Section Abstract Doc Link 8055222 Disease Relevance 1.46 Pain Relevance 0.10
CONCLUSION: Acetaminophen poisoning may cause the serum transaminase level to increase during the 24 hours after ingestion.


Spec (may) Positive_regulation (cause) of Positive_regulation (increase) of transaminase
8) Confidence 0.09 Published 1995 Journal Ann Emerg Med Section Body Doc Link 7793720 Disease Relevance 0 Pain Relevance 0
Administration of paracetamol resulted in elevated levels of GPT, GOT, AKKP and TB by three to four folds indicating development of hepatotoxicity.
Positive_regulation (resulted) of Positive_regulation (elevated) of GOT associated with paracetamol and hepatotoxicity
9) Confidence 0.05 Published 2010 Journal Pharmacognosy Magazine Section Body Doc Link PMC2900060 Disease Relevance 0.28 Pain Relevance 0.16
The compounds prevented the inflammation induced increase in serum transaminase levels and leucocyte counts.
Positive_regulation (induced) of Positive_regulation (increase) of serum transaminase in leucocyte associated with inflammation
10) Confidence 0.04 Published 1987 Journal Arzneimittelforschung Section Abstract Doc Link 3496890 Disease Relevance 0.97 Pain Relevance 0.31

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