INT79093

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Context Info
Confidence 0.70
First Reported 1999
Last Reported 2011
Negated 6
Speculated 3
Reported most in Abstract
Documents 101
Total Number 104
Disease Relevance 46.89
Pain Relevance 59.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Nos1) mitochondrion (Nos1) oxidoreductase activity (Nos1)
plasma membrane (Nos1) cytoskeleton (Nos1) nucleus (Nos1)
Anatomy Link Frequency
neuronal 18
spinal cord 8
sciatic nerve 4
brainstem 3
peritoneum 2
Nos1 (Mus musculus)
Pain Link Frequency Relevance Heat
Morphine 952 100.00 Very High Very High Very High
opioid receptor 932 100.00 Very High Very High Very High
Spinal cord 668 100.00 Very High Very High Very High
Kinase C 488 100.00 Very High Very High Very High
dorsal root ganglion 456 100.00 Very High Very High Very High
Hippocampus 298 100.00 Very High Very High Very High
medulla 212 100.00 Very High Very High Very High
Neuronal nitric oxide synthase 75 100.00 Very High Very High Very High
cocaine 50 100.00 Very High Very High Very High
Inflammatory mediators 23 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Ganglion Cysts 468 100.00 Very High Very High Very High
INFLAMMATION 409 100.00 Very High Very High Very High
Hypersensitivity 409 100.00 Very High Very High Very High
Nervous System Injury 945 99.98 Very High Very High Very High
Targeted Disruption 1055 99.96 Very High Very High Very High
Neuropathic Pain 599 99.92 Very High Very High Very High
Inflammatory Pain 114 99.90 Very High Very High Very High
Amyloid Plaque 16 99.74 Very High Very High Very High
Pain 243 99.64 Very High Very High Very High
Cv Unclassified Under Development 85 99.48 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The MOR(-/-) mice showed a significantly higher morphine-induced nNOS expression level (+103%) or a lower cocaine-induced nNOS expression level (+38%) in the DG than in the morphine- or cocaine-treated MOR(+/+) mice.
Positive_regulation (induced) of nNOS associated with hippocampus, cocaine and morphine
1) Confidence 0.70 Published 2006 Journal Neurosci. Lett. Section Abstract Doc Link 16300892 Disease Relevance 0.08 Pain Relevance 1.70
The MOR(-/-) mice showed a significantly higher morphine-induced nNOS expression level (+103%) or a lower cocaine-induced nNOS expression level (+38%) in the DG than in the morphine- or cocaine-treated MOR(+/+) mice.
Positive_regulation (induced) of nNOS associated with hippocampus, cocaine and morphine
2) Confidence 0.70 Published 2006 Journal Neurosci. Lett. Section Abstract Doc Link 16300892 Disease Relevance 0.08 Pain Relevance 1.71
Here we examined the N/OFQ signal pathways coupled to nNOS activation in the spinal cord by using this ex vivo system.
Spec (examined) Positive_regulation (activation) of nNOS in spinal cord associated with spinal cord
3) Confidence 0.69 Published 2007 Journal Neuropharmacology Section Abstract Doc Link 17350656 Disease Relevance 0.09 Pain Relevance 0.61
Considering that NMDA receptor triggers activation of neuronal nitric oxide synthase (nNOS), enzyme that produces nitric oxide (NO), this study investigated the effects of intra-PAG infusions of NPLA (Nomega-propyl-L-arginine), an nNOS inhibitor, on behavioral and antinociceptive responses induced by local injection of NMDA receptor agonist in mice.
Positive_regulation (activation) of nNOS in neuronal associated with nmda receptor, agonist, antinociceptive, central grey and neuronal nitric oxide synthase
4) Confidence 0.69 Published 2006 Journal Brain Res. Section Abstract Doc Link 16476419 Disease Relevance 0.53 Pain Relevance 0.63
Considering that NMDA receptor triggers activation of neuronal nitric oxide synthase (nNOS), enzyme that produces nitric oxide (NO), this study investigated the effects of intra-PAG infusions of NPLA (Nomega-propyl-L-arginine), an nNOS inhibitor, on behavioral and antinociceptive responses induced by local injection of NMDA receptor agonist in mice.
Positive_regulation (activation) of neuronal nitric oxide synthase in neuronal associated with nmda receptor, agonist, antinociceptive, central grey and neuronal nitric oxide synthase
5) Confidence 0.69 Published 2006 Journal Brain Res. Section Abstract Doc Link 16476419 Disease Relevance 0.53 Pain Relevance 0.63
The increased level of nNOS protein in the DRG was seen in the small, medium, and large cell bodies [20].
Positive_regulation (increased) of nNOS protein associated with dorsal root ganglion
6) Confidence 0.68 Published 2007 Journal Mol Pain Section Body Doc Link PMC2089056 Disease Relevance 1.33 Pain Relevance 0.80
CoCl2 significantly increased the level of endogenous nitric oxide synthase inhibitor asymmetric dimethylarginine (ADMA), which markedly increased intracellular ROS production and promoted inflammatory responses, resulting in caspase-3-dependent apoptosis.
Positive_regulation (increased) of nitric oxide synthase associated with inflammatory response and apoptosis
7) Confidence 0.67 Published 2010 Journal Virol J Section Body Doc Link PMC2887434 Disease Relevance 0.81 Pain Relevance 0.08
Nitric oxide (NO) serves as a retrograde messenger to activate neuronal NO synthase in the spinal cord via NMDA receptors.
Positive_regulation (activate) of neuronal NO synthase in spinal cord associated with nmda receptor and spinal cord
8) Confidence 0.66 Published 2007 Journal Nitric Oxide Section Title Doc Link 17548218 Disease Relevance 0.09 Pain Relevance 0.41
Thus and according to that occurs with the mRNA levels, while sciatic nerve ligation significantly increases the NOS1 protein levels in WT mice it did not change their expression in NOS2-KO animals, when comparing sham-operated vs. sciatic nerve-injured animals (one way ANOVA, p<0.001).
Positive_regulation (increases) of NOS1 protein in sciatic nerve associated with targeted disruption and sciatic nerve
9) Confidence 0.66 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001461 Disease Relevance 0.51 Pain Relevance 0.50
It is worth emphasizing that, although the activity of nNOS has been shown to be increased in the late phase of delayed IP[12], to the best of our knowledge, the activity of the enzyme has not been determined in early IP.
Positive_regulation (increased) of nNOS
10) Confidence 0.65 Published 2010 Journal BMC Physiol Section Body Doc Link PMC2927582 Disease Relevance 0.56 Pain Relevance 0.15
Moreover, the MOR(-/-) mice also showed significantly higher morphine- or cocaine-induced nNOS expression levels in the DG than in the saline treated MOR(+/+) mice (morphine, +234%; cocaine, +54%).
Positive_regulation (induced) of nNOS associated with hippocampus, cocaine and morphine
11) Confidence 0.61 Published 2006 Journal Neurosci. Lett. Section Abstract Doc Link 16300892 Disease Relevance 0.09 Pain Relevance 1.69
N/OFQ enhanced nNOS activity in the superficial layer of the spinal cord, as assessed by NADPH-diaphorase histochemistry, in a time- and dose-dependent manner.
Positive_regulation (enhanced) of nNOS in spinal cord associated with spinal cord
12) Confidence 0.60 Published 2007 Journal Neuropharmacology Section Abstract Doc Link 17350656 Disease Relevance 0.08 Pain Relevance 0.61
We recently established an ex vivo system to elucidate biochemical and molecular mechanisms for nNOS activation by the use of a combination of isolated intact spinal cord preparations and NADPH-diaphorase histochemistry.
Positive_regulation (activation) of nNOS in spinal cord associated with spinal cord
13) Confidence 0.60 Published 2007 Journal Neuropharmacology Section Abstract Doc Link 17350656 Disease Relevance 0.09 Pain Relevance 0.57
Some of them are also positive for neuronal nitric oxide synthase, which is also induced following peripheral inflammation.
Positive_regulation (positive) of neuronal nitric oxide synthase in neuronal associated with inflammation and neuronal nitric oxide synthase
14) Confidence 0.60 Published 2000 Journal Neuroscience Section Abstract Doc Link 11113358 Disease Relevance 0.26 Pain Relevance 0.52
Both, nNOS and iNOS were upregulated in the dorsal horns of the spinal cord in response to the zymosan challenge.
Positive_regulation (upregulated) of nNOS in dorsal horns associated with spinal cord
15) Confidence 0.59 Published 2000 Journal Neurosci. Lett. Section Abstract Doc Link 10925177 Disease Relevance 0.16 Pain Relevance 0.18
Such adaptations suggest that the increased nNOS in the DRG may be involved in the mechanism underlying the development and/or maintenance of neuropathic pain.
Positive_regulation (increased) of nNOS associated with dorsal root ganglion and neuropathic pain
16) Confidence 0.59 Published 2007 Journal Mol Pain Section Body Doc Link PMC2089056 Disease Relevance 1.20 Pain Relevance 0.90
Likewise, tight, unilateral ligature of the rat L5 and L6 spinal nerves increased nNOS mRNA in ipsilateral L5/6 DRG neurons, but not in dorsal horn, beginning 1 day after nerve ligation and lasting for at least 13 weeks [19].
Neg (not) Positive_regulation (increased) of nNOS in nerve associated with dorsal root ganglion and dorsal horn
17) Confidence 0.59 Published 2007 Journal Mol Pain Section Body Doc Link PMC2089056 Disease Relevance 1.19 Pain Relevance 0.81
A corresponding increase in DRG (but not spinal cord) nNOS protein was also observed and localized mainly to small and occasionally medium-sized sensory neurons [19,21].
Positive_regulation (increase) of nNOS protein in sensory neurons associated with dorsal root ganglion and spinal cord
18) Confidence 0.59 Published 2007 Journal Mol Pain Section Body Doc Link PMC2089056 Disease Relevance 1.16 Pain Relevance 0.89
We found that nNOS in the ipsilateral (but not in the contralateral) fifth DRG was increased after the L5 spinal nerve injury (Fig. 5).
Positive_regulation (increased) of nNOS in spinal nerve associated with dorsal root ganglion and nervous system injury
19) Confidence 0.59 Published 2007 Journal Mol Pain Section Body Doc Link PMC2089056 Disease Relevance 1.23 Pain Relevance 0.56
Other studies have shown that nNOS activity increases in several brain regions of aged SAMP8, SAMP10 and rats [17,22,26] suggesting that the increase production in NO can lead to an increased release of glutamate in the brain with aging [25].
Positive_regulation (increases) of nNOS in brain associated with glutamate and aging
20) Confidence 0.59 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1766358 Disease Relevance 0.38 Pain Relevance 0.21

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