INT79094

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Context Info
Confidence 0.35
First Reported 1999
Last Reported 1999
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.09
Pain Relevance 1.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (PDYN, PRL) cell proliferation (PRL) cytosol (PRL)
cell death (PDYN) plasma membrane (PDYN)
PDYN (Homo sapiens)
PRL (Homo sapiens)
Pain Link Frequency Relevance Heat
Dynorphin 11 100.00 Very High Very High Very High
Kappa opioid receptor 3 99.32 Very High Very High Very High
narcan 2 97.80 Very High Very High Very High
antagonist 2 97.58 Very High Very High Very High
Opioid 1 97.36 Very High Very High Very High
opioid receptor 3 91.48 High High
alcohol 1 88.00 High High
mu opioid receptor 1 79.20 Quite High
Delta opioid receptors 1 69.76 Quite High
cocaine 3 56.72 Quite High
Disease Link Frequency Relevance Heat
Alcohol Addiction 1 88.24 High High
Drug Dependence 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Pretreatment with the opioid antagonist nalmefene (30 mg i.v.), which has high affinity at both mu- and kappa-opioid receptors, caused a greater attenuation in dynorphin A1-13-stimulated increases in serum prolactin levels than pretreatment with similarly high doses of naloxone, an antagonist with lower affinity for both mu- and kappa-opioid receptors.
dynorphin Positive_regulation (increases) of prolactin associated with dynorphin, antagonist, narcan, kappa opioid receptor and opioid
1) Confidence 0.35 Published 1999 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9862779 Disease Relevance 0.09 Pain Relevance 1.07

General Comments

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